Methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and diabetic nephropathy susceptibility in patients with type 2 diabetes mellitus

Abstract

Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme that regulates nucleotide synthesis and DNA methylation. The MTHFR C677T gene polymorphism (rs1801133), a C ! T transition at nucleotide 677 in exon 4, is a common gene variant of MTHFR and has been implicated in diabetic nephropathy, albeit with inconsistent results. Here, we performed a meta-analysis to assess the common effect size of this polymorphism on DN susceptibility. Case-control studies on the association of the MTHFR C677T gene polymorphism with DN risk were retrieved from databases up to August 1, 2013, and eligible studies were recruited into the meta-analysis and further analyzed. Of 132 studies, 33 were identified as suitable for this analysis. The results showed that T allele and TT genotype were distinctly associated with DN susceptibility in the overall population and Asians, and might be a risk factor in Caucasians and Africans (T allele: Overall population: p50

Association between end‐stage diabetic nephropathy and MTHFR (C677T and A1298C) gene polymorphisms

“…Although a clear genetic component is observable for DN, these metaanalyses yielded heterogonous results. 2,[39][40][41] The other studied MTHFR A1298C polymorphism was reported to be negatively associated with DN in Jewish 38 and Polish 37 populations. In contrast to this, the present study found a significant association between the MTHFR A1298C polymorphism and DN.…”

“…For the past few years, several meta‐analyses were conducted in different ethnic populations to find out the possible association between MTHFR C677T gene polymorphism and DN susceptibility. Although a clear genetic component is observable for DN, these meta‐analyses yielded heterogonous results . The other studied MTHFR A1298C polymorphism was reported to be negatively associated with DN in Jewish and Polish populations.…”

The relationship between estimated glomerular filtration rate trajectory and all-cause mortality in type 2 diabetes: the Fremantle Diabetes Study

“…In addition to conventional modifiable risk factors for renal disease such as hypertension and glycaemia, the availability of genetic determinants would strengthen such an analysis. In the case of diabetic renal disease, these would include polymorphisms of the ACE (9), angiotensin II type 1 receptor (AT1R) (10), apolipoprotein E (APOE) (11) and methylenetetrahydrofolate reductase (MTHFR) (12) genes.…”

Investigation of the relationship between MTHFR, IRS and CALCA gene polymorphisms and development of diabetic nephropathy in patients with type 2 diabetes mellitus

“…In an Emirati population, the MTHFR C677T and A1298C gene polymorphisms were not related to type 2 DM. However, these polymorphisms could be used as risk markers for CVA, nephropathy, high LDL cholesterol and triglycerides in type 2 DM patients [32]. Analysis of many different populations indicated that the MTHFR C677T T allele or TT genotype might be a significant genetic molecular marker to determine the risk of DN in patients with type 2 DM [33].…”