A mathematical model for pH-responsive ionically crosslinked TEMPO nanocellulose hydrogel design in drug delivery systems

Kopač, Tilen; Krajnc, Matjaž; Ručigaj, Aleš

doi:10.1016/j.ijbiomac.2020.11.126

Cited by 37 publications

(40 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The best-known hydrogel synthesis is performed by ionic crosslinking with divalent ions, such as calcium(II) ions, which keeps the system non-toxic and suitable for medical and pharmaceutical use [ 27 , 28 ]. The mechanism of hydrogel formation is based on ionic interactions of the carboxyl functional groups present in the TOCNF with pK a 3.9 [ 29 , 30 ]. Their protonation causes hydrogel and pore shrinkage at pH < pK a due to polymer chain attraction, while hydrogel and pore swelling is due to deprotonation at pH > pK a due to polymer chain repulsion [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism of hydrogel formation is based on ionic interactions of the carboxyl functional groups present in the TOCNF with pK a 3.9 [ 29 , 30 ]. Their protonation causes hydrogel and pore shrinkage at pH < pK a due to polymer chain attraction, while hydrogel and pore swelling is due to deprotonation at pH > pK a due to polymer chain repulsion [ 30 ]. Moreover, unlike sodium alginate, the most commonly used biopolymer in drug delivery [ 31 ], TOCNF can be crosslinked without the addition of a crosslinking agent by hydrogen bond formation.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

et al. 2021

Self Cite

View full text Add to dashboard Cite

The role of bacteriophage therapy in medicine has recently regained an important place. Oral phage delivery for gastrointestinal treatment, transport through the stomach, and fast release in the duodenum is one of such applications. In this work, an efficient polyHIPE/hydrogel system for targeted delivery of bacteriophages with rapid release at the target site is presented. T7 bacteriophages were encapsulated in low crosslinked anionic nanocellulose-based hydrogels, which successfully protected phages at pH < 3.9 (stomach) and completely lost the hydrogel network at a pH above 3.9 (duodenum), allowing their release. Hydrogels with entrapped phages were crosslinked within highly porous spherical polyHIPE particles with an average diameter of 24 μm. PolyHIPE scaffold protects the hydrogels from mechanical stimuli during transport, preventing the collapse of the hydrogel structure and the unwanted phage release. On the other hand, small particle size, due to the large surface-to-volume ratio, enables rapid release at the target site. As a consequence, a fast zero-order release was achieved, providing improved patient compliance and reduced frequency of drug administration. The proposed system therefore exhibits significant potential for a targeted drug delivery in medicine and pharmacy.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Kopac et al [ 181 ] pointed out that the main parameter for controlling the drug delivery rate in an anionic hydrogel-based nanocellulose is the average pore size (mesh size), controlled by selecting cross-linked and biopolymer concentration along with the adjustment of pH and temperature. The changes in the ionic strength and hydrogen bonding of functional groups in the internal hydrogel structure are responsible for altering the polymeric hydrogel network, which affected the average pore size of hydrogel ( Figure 13 ).…”

Section: Hydrogel Based Nanocellulose For Drug Deliverymentioning

confidence: 99%

“…Due to the smaller hydrodynamic size of the drug relative to the mesh size, the drug can rapidly diffuse through the hydrogel network and vice versa without a steric barrier. However, both drugs can have a similar drug release rate by modulating the mesh size through cross-linking density and biopolymer ratio variation [ 181 ].…”

Section: Hydrogel Based Nanocellulose For Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers

et al. 2021

View full text Add to dashboard Cite

The ‘Back-to-nature’ concept has currently been adopted intensively in various industries, especially the pharmaceutical industry. In the past few decades, the overuse of synthetic chemicals has caused severe damage to the environment and ecosystem. One class of natural materials developed to substitute artificial chemicals in the pharmaceutical industries is the natural polymers, including cellulose and its derivatives. The development of nanocelluloses as nanocarriers in drug delivery systems has reached an advanced stage. Cellulose nanofiber (CNF), nanocrystal cellulose (NCC), and bacterial nanocellulose (BC) are the most common nanocellulose used as nanocarriers in drug delivery systems. Modification and functionalization using various processes and chemicals have been carried out to increase the adsorption and drug delivery performance of nanocellulose. Nanocellulose may be attached to the drug by physical interaction or chemical functionalization for covalent drug binding. Current development of nanocarrier formulations such as surfactant nanocellulose, ultra-lightweight porous materials, hydrogel, polyelectrolytes, and inorganic hybridizations has advanced to enable the construction of stimuli-responsive and specific recognition characteristics. Thus, an opportunity has emerged to develop a new generation of nanocellulose-based carriers that can modulate the drug conveyance for diverse drug characteristics. This review provides insights into selecting appropriate nanocellulose-based hybrid materials and the available modification routes to achieve satisfactory carrier performance and briefly discusses the essential criteria to achieve high-quality nanocellulose.

show abstract

Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Feng

Wang

2023

Advanced Science

View full text Add to dashboard Cite

Hydrogels with tailor‐made swelling‐shrinkable properties have aroused considerable interest in numerous biomedical domains. For example, as swelling is a key issue for blood and wound extrudates absorption, the transference of nutrients and metabolites, as well as drug diffusion and release, hydrogels with high swelling capacity have been widely applicated in full‐thickness skin wound healing and tissue regeneration, and drug delivery. Nevertheless, in the fields of tissue adhesives and internal soft‐tissue wound healing, and bioelectronics, non‐swelling hydrogels play very important functions owing to their stable macroscopic dimension and physical performance in physiological environment. Moreover, the negative swelling behavior (i.e., shrinkage) of hydrogels can be exploited to drive noninvasive wound closure, and achieve resolution enhancement of hydrogel scaffolds. In addition, it can help push out the entrapped drugs, thus promote drug release. However, there still has not been a general review of the constructions and biomedical applications of hydrogels from the viewpoint of swelling‐shrinkable properties. Therefore, this review summarizes the tactics employed so far in tailoring the swelling‐shrinkable properties of hydrogels and their biomedical applications. And a relatively comprehensive understanding of the current progress and future challenge of the hydrogels with different swelling‐shrinkable features is provided for potential clinical translations.

show abstract

A mathematical model for pH-responsive ionically crosslinked TEMPO nanocellulose hydrogel design in drug delivery systems

Cited by 37 publications

References 55 publications

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

Bacteriophage Delivery Systems Based on Composite PolyHIPE/Nanocellulose Hydrogel Particles

Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers

Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

Contact Info

Product

Resources

About