A long-term evaluation of experimental potassium oxalate concentrations on dentin hypersensitivity reduction: A triple-blind randomized clinical trial

Galvão, Alexia da Mata; Zeola, Livia Fávaro; Moura, Guilherme Faria; Teixeira, Daniela Navarro Ribeiro; Gonzaga, Ramon Corrêa de Queiroz; Silva, Gisele Rodrigues da; Soares, Paulo Vinícius

doi:10.1016/j.jdent.2019.103180

Cited by 13 publications

(8 citation statements)

References 43 publications

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“…O oxalato de potássio apresenta dupla função, sendo neural e obliterador. Logo, foi avaliado no estudo de Galvão et al, (2019), onde observou-se a efetividade da substância desde a primeira aplicação.…”

Section: Discussionunclassified

Tratamento químico para hipersensibilidade dentinária ‒ Parte 1

Silva

Rodrigues

et al. 2020

RSD

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Objetivo: Realizar uma revisão de literatura acerca do uso de substâncias químicas utilizadas no tratamento da hipersensibilidade dentinária (HD), assim como particularidades relacionadas ao método proposto. Metodologia: Foi realizada uma pesquisa bibliográfica, através de busca na base de dados Medline (Medical Literature Analysis and Retrievel System Online) buscando estudos sem restrição de data de publicação até junho de 2020, sendo estes em inglês e que retratassem o tema abordado. A busca na base de dados foi realizada durante os meses de abril e maio de 2020. Para a busca, foram utilizados os descritores: “dentin sensitivity”, “hypersensitivity” e “dental care”. Resultados: Os estudos demostram heterogeneidade a respeito dos métodos de tratamento, incluindo também a diversidade de substâncias usadas. Entretanto, há um direcionamento favorável na utilização do método químico, combinando agentes neurais e obliteradores. Conclusão: Diante disso, o método químico apresenta bons resultados para o tratamento da HD, mesmo com a ausência de um protocolo clínico para o procedimento. Quando há a combinação do agente neural com o obliterador observa-se resultados superiores.

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Section: Discussionunclassified

Tratamento químico para hipersensibilidade dentinária ‒ Parte 1

Silva

Rodrigues

et al. 2020

RSD

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“…When the acid oxalic is applied on the dentin surface, it liberates calcium ions from the dissolution of hydroxyapatite to form calcium oxalate crystals and polymer-Ca complex 6,7,15,21,22 . The efficacy of oxalate desensitizer in permeability reduction has been demonstrated 16,18,22 . However, previous studies have shown that the desensitizing effect promotes by the oxalic acid may not be permanent.…”

Section: Discussionmentioning

confidence: 99%

“…These methods include the occlusion of dentinal tubules through the application of sedative agents [3][4][5]10 , cavity varnishes, dentin bonding agents 11 , resin composite restorations, lasers 12,13 , and dentin remineralization strategies 14,15 . However, the most frequent treatment consists in occluding the dentinal tubule through the use of desensitizer agents 2,9 , which are based on fluoride, oxalate, potassium nitrate, and calcium phosphate 6,9,16 .…”

Section: Introductionmentioning

confidence: 99%

Influence of desensitizers agents on the dentin bond strength after one-year water storage

2020

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Aim: Evaluate the effect of adhesives systems combined with desensitizer agents on the microtensile bond strength (μTBS) of a composite resin to dentin. Methods: Cervical dentin of thirty-two human molars were used to simulate hypersensitivity areas. The teeth were divided into four groups (n=8), according to the type of adhesive system and desensitizer agents. No desensitizer was used in the control (Clearfil SE Bond – CS). Two experimental groups were pretreated with either MS Coat Bond (MS) or Biofluorid 12 (BF) immediately prior to bonding with CS. The last group corresponded to Gluma Comfort Bond + Desensitizer (GC) application. After dentin treatments, a composite block was built-up on dentin surface and after 24 hours teeth were serially sectioned to obtain bonded bean specimens. Beams were stored in water for 24 hours or one year. Subsequently, the specimens were submitted to the μTBS test. Data were analyzed by two-way mixed ANOVA and Bonferroni’s test (α = 0.05). Results: At 24 hours, there was no significant difference in μTBS among groups. However, at one year, dentin treated with MS or BF demonstrated significantly lower μTBS of CS to dentin compared to control and GC, which kept their μTBS stable. Conclusion: The effect of MS and BF desensitizer agents on the μTBS of CS to dentin did not reduce the μTBS at 24 hours, but it decreases significantly after one year.

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“…Facilitating natural mineral formation is also considered to be effective. 5 At present, most of the compounds such as strontium, 6 calcium phosphate, 7 soluble oxalates, 8 and bioactive glasses 9 function by physically blocking open dentin tubules. However, their efficacy is limited, and the precipitating materials/or treating agents can be washed by saliva and are vulnerable to mechanical abrasion.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic oligopeptide formed enamel-like tissue and dentin tubule occlusion via mineralization for dentin hypersensitivity treatment

Wang

Zhao

et al. 2021

Journal of Applied Biomaterials & Functional Materials

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Objective: Dentin hypersensitivity (DH) is a common oral disease with approximately 41.9% prevalence. Reconstruction of dental hard tissues is the preferred treatment for relieving DH. Here, we applied biomineralization method using oligopeptide simulating cementum protein 1 (CEMP1) to regenerate hard tissues on demineralized dentin. Methods: The self-assembly and biomineralization property of the oligopeptide were detected by scanning electron microscopy (SEM), circular dichroism spectroscopy, and transmission electron microscopy. Oligopeptide’s binding capacity to demineralized dentin was evaluated by SEM and attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR). Remineralization was characterized using SEM, ATR-FTIR, X-ray diffraction, and nanoindentation. Oligopeptide’s biocompatibility was evaluated using periodontal ligament cells. Results: Oligopeptides self-assembled into nano-matrix and templated mineral precursor formation within 24 h. Moreover, oligopeptide nano-matrix bound firmly on demineralized dentin and resisted water rinsing. Then, bound nano-matrix served as a template to initiate nucleation and transformation of hydroxyapatite on demineralized dentin. After 96 h, oligopeptide nano-matrix regenerated an enamel-like tissue layer with a thickness of 15.35 μm, and regenerated crystals occluded dentin tubules with a depth of 31.27 μm. Furthermore, the oligopeptide nano-matrix had good biocompatibility when co-cultured with periodontal ligament cells. Conclusions: This biomimetic oligopeptide simulating CEMP1 effectively induced remineralization and reconstructed hard tissues on demineralized dentin, providing a potential biomaterial for DH treatment.

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A long-term evaluation of experimental potassium oxalate concentrations on dentin hypersensitivity reduction: A triple-blind randomized clinical trial

Cited by 13 publications

References 43 publications

Tratamento químico para hipersensibilidade dentinária ‒ Parte 1

Tratamento químico para hipersensibilidade dentinária ‒ Parte 1

Influence of desensitizers agents on the dentin bond strength after one-year water storage

Biomimetic oligopeptide formed enamel-like tissue and dentin tubule occlusion via mineralization for dentin hypersensitivity treatment

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