A long-term controlled release of the drug for osteoporosis from the surface of titanium implants coated with calcium zeolite

Sandomierski, Mariusz; Zielińska, Maryla; Voelkel, Adam

doi:10.1039/d1qm00414j

Cited by 13 publications

(13 citation statements)

References 47 publications

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“…The layer was prepared based on a previously described methodology [ 6 ]. Initially, the titanium alloy, Ti6Al4V, was subjected to abrasion with 120 grit sandpaper.…”

Section: Methodsmentioning

confidence: 99%

“…It is necessary to replace the weakened bone with an implant. Therefore, it is necessary to look at the prospects related to the possibility of modifying the surface of materials intended for their production in order to improve their properties and positively influence the regeneration process and osseointegration [ 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…With regard to the treatment of osteoporotic conditions, it is interesting that porous zeolite layers can be used to modify titanium materials. Thanks to their application, it will be possible to create drug carriers that can be released from the implant surface [ 6 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Characterization of Magnesium and Zinc Forms of Sodalite Coatings on Ti6Al4V ELI for Potential Application in the Release of Drugs for Osteoporosis

et al. 2023

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Osteoporosis is the most common metabolic disease of the skeletal system and is characterized by impaired bone strength. This translates into an increased risk of low-energy fractures, which means fractures caused by disproportionate force. This disease is quite insidious, its presence is usually detected only at an advanced stage, where treatment with pharmaceuticals does not produce sufficient results. It is obligatory to replace the weakened bone with an implant. For this reason, it is necessary to look at the possibilities of surface modification used in tissue engineering, which, in combination with the drugs for osteoporosis, i.e., bisphosphonates, may constitute a new and effective method for preventing the deterioration of the osteoporotic state. To achieve this purpose, titanium implants coated with magnesium or zinc zeolite were prepared. Both the sorption and release profiles differed depending on the type of ion in the zeolite structure. The successful release of risedronate from the materials at a low level was proven. It can be concluded that the proposed solution will allow the preparation of endoprostheses for patients with bone diseases such as osteoporosis.

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“…The layer was prepared based on a previously described methodology [ 6 ]. Initially, the titanium alloy, Ti6Al4V, was subjected to abrasion with 120 grit sandpaper.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Characterization of Magnesium and Zinc Forms of Sodalite Coatings on Ti6Al4V ELI for Potential Application in the Release of Drugs for Osteoporosis

et al. 2023

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“…Among the BPCCs previously reported, nanocrystals of a zoledronate (ZOLE)-based BPCC (ZOLE-Ca form II) named nano -Ca@ZOLE have demonstrated the greatest potential as therapy for the treatment and prevention of OM. , Compared to other BPCCs, these presented higher thermal and structural stability in physiological media, higher binding affinity (∼2.5 x more than ZOLE) to hydroxyapatite in a relevant time frame (24 h), and higher cytotoxicity effects even at the lowest concentrations against a cancerous cell line model (MDA-MB-231) without inducing any negative effect in normal osteoblast-like cells (hFOB 1.19). , Additionally, compared to other BPs such as alendronate and risedronate, reports on immobilization attempts of ZOLE or its derivatives in titanium surfaces have not been reported. , …”

Section: Introductionmentioning

confidence: 99%

Functionalization of Titanium Dioxide by In Situ Surface Crystallization of Bisphosphonate-Based Coordination Complexes

et al. 2022

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Functionalization of highly pure rutile phase titanium dioxide (TiO2) particles with a selected bisphosphonate-based coordination complex (BPCC), ZOLE-Ca form II, was achieved through in situ surface crystallization. The hydrothermal reaction of the selected BPCC was carried out in the presence of photoactivated rutile phase TiO2 by ultraviolet irradiation. The reaction time was varied to control the crystal growth of the BPCC around the TiO2 core, resulting in a functionalized material with different shell thicknesses: TiO2-core:nano-Ca@ZOLE-shell-† (5 min) and TiO2-core:nano-Ca@ZOLE-shell-‡ (10 min). The crystal phase assessment of the BPCC and the polymorphic phase purity of the metal oxide were determined after immobilization through Raman spectroscopy and powder X-ray diffraction. The results initially suggested that the crystallization of a shell comprising the selected BPCC surrounding a highly pure rutile phase TiO2 core was achieved through controlled in situ surface crystallization. Morphological changes, elemental composition and exact atomic distribution in the functionalized materials were addressed employing scanning electron microscopy coupled with energy-dispersive spectroscopy. These analyses unambiguously confirmed that after 5 min, successful incorporation of a thin BPCC shell on the surface of the metal oxide particles was achieved. Particle size distribution measurements revealed an average particle size of 495 d.nm for the functionalized material after the immobilization process. Quantitative determination of the BPCC shell content in TiO2-core:nano-Ca@ZOLE-shell-† was determined through thermogravimetric analysis, estimating a ratio of ∼1:3 (TiO2:BPCC). The cytotoxicity of TiO2-core:nano-Ca@ZOLE-shell-† against MDA-MB-231 (cancer cell model) and hFOB 1.19 (normal osteoblast-like cell model) cell lines was investigated. The results demonstrated significant cell growth inhibition for TiO2-core:nano-Ca@ZOLE-shell-† against MDA-MB-231, specifically at a concentration of 7.5 μM (% RCL = 46 ± 2%, 72 h). Under the same conditions, the functionalized material did not present cytotoxicity against hFOB 1.19 (% RCL ∼ 100%). These important outcomes provide evidence of the surface crystallization of BPCCs onto rutile phase TiO2 for the development of a novel functionalized material with the potential to treat and prevent osteolytic metastases.

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“…Titanium implants coated with calcium zeolite were used as controlled delivery systems (CDSs) for the drug risedronate (RIS). It was found that one year is needed for the release of 30% of the total drug quantity [6]. Biphasic calcium phosphate (BCP) scaffolds were loaded with the drug alendronate (ALE).…”

Section: Introductionmentioning

confidence: 99%

Calcium and Strontium Coordination Polymers as Controlled Delivery Systems of the Anti-Osteoporosis Drug Risedronate and the Augmenting Effect of Solubilizers

et al. 2021

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Bisphosphonates (BPs) constitute a class of drugs used for the treatment of calcium- and bone-related disorders, including osteoporosis, Paget’s disease, etc. The presence of the anionic phosphonate groups endows them with the ability to act as ligands to metal ions. As a result, the synthesis of complexes or coordination polymers of various structural motifs can be accomplished. In this work, the 3rd generation BP drug risedronate (RIS) was combined with biologically acceptable alkaline earth metal ions (e.g., Ca2+ and Sr2+) in an effort to synthesize new materials. These metal–RIS compounds can operate as controlled delivery systems (CDSs) when exposed to appropriate experimental conditions, such as the low pH of the human stomach. CDS networks containing Ca2+ or Sr2+ and RIS were physicochemically and structurally characterized and were evaluated for their ability to release the free RIS drug during an acid-driven hydrolysis process. Due to the low solubility of RIS at low pH, cationic additives (linear polyethyleneimine and amine-terminated polyaminoamide dendrimer) were utilized as drug solubilizers. Based on the drug release results of this study, there was an attempt to correlate the drug release efficiency with the structural features of these CDSs.

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A long-term controlled release of the drug for osteoporosis from the surface of titanium implants coated with calcium zeolite

Abstract: The aim of this study was to prepare an implant material enabling a slow, gradual and gentle release of risedronate. Such material was designed to allow the sorption of large...

Cited by 13 publications

References 47 publications

Characterization of Magnesium and Zinc Forms of Sodalite Coatings on Ti6Al4V ELI for Potential Application in the Release of Drugs for Osteoporosis

Characterization of Magnesium and Zinc Forms of Sodalite Coatings on Ti6Al4V ELI for Potential Application in the Release of Drugs for Osteoporosis

Functionalization of Titanium Dioxide by In Situ Surface Crystallization of Bisphosphonate-Based Coordination Complexes

Calcium and Strontium Coordination Polymers as Controlled Delivery Systems of the Anti-Osteoporosis Drug Risedronate and the Augmenting Effect of Solubilizers

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