Characterization of Magnesium and Zinc Forms of Sodalite Coatings on Ti6Al4V ELI for Potential Application in the Release of Drugs for Osteoporosis

Abstract

Osteoporosis is the most common metabolic disease of the skeletal system and is characterized by impaired bone strength. This translates into an increased risk of low-energy fractures, which means fractures caused by disproportionate force. This disease is quite insidious, its presence is usually detected only at an advanced stage, where treatment with pharmaceuticals does not produce sufficient results. It is obligatory to replace the weakened bone with an implant. For this reason, it is necessary to look at the possibilities of surface modification used in tissue engineering, which, in combination with the drugs for osteoporosis, i.e., bisphosphonates, may constitute a new and effective method for preventing the deterioration of the osteoporotic state. To achieve this purpose, titanium implants coated with magnesium or zinc zeolite were prepared. Both the sorption and release profiles differed depending on the type of ion in the zeolite structure. The successful release of risedronate from the materials at a low level was proven. It can be concluded that the proposed solution will allow the preparation of endoprostheses for patients with bone diseases such as osteoporosis.

Surface Modification of Ti6Al4V ELI Titanium Alloy by Poly(ethylene-alt-maleic anhydride) and Risedronate Sodium

“…In the next and last step of the modification, the drug was attached by a coordination bond (between the Zn and RSD molecules) [15]. The use of zinc ions for the drug sorption process was based on the results of studies on zinc zeolites [16], where the obtained Zeo-Zn-RSD coating was characterized by good strength properties as well as the parameters (amount) of the drug released from the surface.…”