A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi

Catalán, César A.N.; Heluani, Carola S. de; Kotowicz, Claudia; Gedris, Thomas E.; Herz, Werner

doi:10.1016/s0031-9422(03)00202-4

Cited by 62 publications

(47 citation statements)

References 16 publications

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“…The compound had been previously reported to possess anti-inflammatory as well as antiplatelet aggregation activities, which are complementary to the observed trypanocidal property. [144][145][146][147][148] Since inflammation poses major problems in the advanced stages of trypanosomiasis, compound 62 represents a promising natural hit with a reasonable selectivity for T. b. rhodesiense.…”

Section: Amidesmentioning

confidence: 99%

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cv¹,

Ntie‐Kang²,

Sh.³

et al. 2018

Preprint

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An absolute configuration of 5R seems to decrease activity of the compound IntroductionProtozoa may be considered as microscopic, essentially single-celled, eukaryotic organisms that are free-living or parasitic (obtaining their food by eating other organisms or their products) in nature. Parasitic protozoal diseases continue to be a cause of considerable morbidity and mortality globally. 1,2Parasitic protozoal diseases include malaria, 3,4 trypanosomiasis (African sleeping sickness and Chagas disease), 5-7 leishmaniasis 8 and schistosomiasis. 9,10 They threaten almost one-third of the world's population, the most numerous incidents being recorded in over 100 Tropical and developing countries and territories, Figure 1. 11,12 Malaria, for example, was reported by the WHO, to be responsible for approximately 214 million sickness cases and 438,000 deaths globally in 2017. 13 The African region recorded the most death-related cases, especially amongst infants below the age of 5 and pregnant women. Schistosomiasis, caused by parasites of the Schistosoma genus are responsible for about 200 million sickness cases and about 280,000 death-related incidents annually worldwide.9,10,14 Only one drug (praziquantel) has been proven to be effective in the treatment of human schistosomiasis, with no vaccine available or in development so far.15-21 Serious concerns about drug selectivity and resistance were raised in 2013 when over 30 million people were treated in Sub-Saharan Africa. 20 Moreover, observed resistance and reduced efficiency of praziquantel in laboratory strains have prompted the search for alternative therapeutic strategies. Trypanosomiasis, which represents several diseases caused by parasites of the genus Trypanosoma, is also of interest. 5,27,29 This disease, which is much arguably the most important disease of man and domesticated animals, accounts for over 8 million reported annual cases globally, especially in the tropical regions of Latin America and Africa. 30,31 Although the present number of cases seems negligible on a worldwide scale, great socioeconomic effects on the endemic areas by this disease are forecast if inadequate attention (both at the communal, national, and international levels) is not given. 7,29,[32][33][34] Leishmaniasis is caused by parasites of the Leishmania type, which is also transmitted by certain types of sandflies. 35,36 The diseases are reported by the WHO to be responsible for about 1 million new cases leading to approximately 30,000 deaths annually on a global scale. The major cause is linked to environmental changes A R T I C L E I N F O A B S T R A C TArticle history:English abstract: Parasitic diseases continue represent a threat on a global scale, particularly among the poorest countries in the world. This is particularly because of the absence of vaccines, and in some cases, resistance against available drugs, currently being used for their treatment. In this review emphasis is laid on natural products and scaffolds from African medicinal plants (AMPs) for lead drug di...

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Section: Amidesmentioning

confidence: 99%

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Cv¹,

Ntie‐Kang²,

Sh.³

et al. 2018

Preprint

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“…The peptide derivatives 1 and 2 were identified by analysis of their spectral data (MS, 1 H-and 13 C-NMR, both 1D and 2D), optical rotations and comparison to the literature (Catalán et al, 2003;Demune et al, 2003;Maiti & Thomson, 1976). The presence of these compounds in the Leguminosae family is rare, and they have only been previously isolated from algae (Maiti & Thomson, 1976), species of Euphorbiaceae (Crotonoideae) (Catalán et al, 2003) Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…The presence of these compounds in the Leguminosae family is rare, and they have only been previously isolated from algae (Maiti & Thomson, 1976), species of Euphorbiaceae (Crotonoideae) (Catalán et al, 2003) Figure 1. Peptides from C. mollis and C. macrophyllum.…”

Section: Resultsmentioning

confidence: 99%

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In vitroacetylcholinesterase activity of peptide derivatives isolated from two species of Leguminosae

Alves¹,

Lima²,

David³

et al. 2013

Pharmaceutical Biology

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Context: Cratylia mollis Martius ex Benth. and Cenostigma macrophyllum Tul. (Leguminosae) are both endemic Brazilian plants and they are used by the natives as medicinal plants, and the leaves of C. mollis are also employed as forage for cattle during the dry season of region. Objective: Isolation of the compounds responsible for the acetylcholinesterase (AChE) inhibition from the CHCl 3 active extract. Materials and methods: Two peptidic compounds were isolated by chromatographic techniques from the CHCl 3 extract of the leaves of C. mollis and C. macrophyllum. They were identified by spectrometric data analysis (MS and NMR) and they were subjected to AChE inhibition employing Ellman's test.

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“…Shoots of C. hieronymi Griseb. have been shown to have strong activity against lung A-549 carcinoma cells, mouse lymphoma and human colon carcinoma (Catalán et al, 2003). The dichloromethane extract of leaves of C. zambesicus Müll.…”

Section: Introductionmentioning

confidence: 99%

Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys

Motta

Furlan

Santos

et al. 2011

Rev. bras. farmacogn.

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Abstract:Croton macrobothrys Baill, Euphorbiaceae, is a tree from the Atlantic Forest in Southern Brazil, used in traditional medicine and popularly known as "dragon's blood" and "pau-sangue". Leaf n-hexane, dichloromethane and methanol extracts were analyzed by GC/MS and evaluated for their in vitro antiproliferative activity on cell lines 786-0 (kidney), HT-29 (colon), K562 (leukemia), NCI-ADR/ RES (drug resistant ovary), NCI-H460 (lung), MCF-7 (mammary), PC-3 (prostate), OVCAR-3 (ovary), U251 (glioma) and UACC-62 (melanoma). The dicloromethane extract exhibited activity against all cell lines at the concentration 25 µg/mL, in particular on cell lines NCI-H460 (GI50 0.33 μg/mL) and K5662 (GI50 0.91 μg/ mL). Relevant constituents in dichloromethane extract are the alkaloids corydine and salutaridine, as well as the diterpenes geranylgeraniol and crotonin-derived clerodanes.

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A linear sesterterpene, two squalene derivatives and two peptide derivatives from Croton hieronymi

Cited by 62 publications

References 16 publications

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

Compounds from African Medicinal Plants with Activities against Protozoal Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis

In vitroacetylcholinesterase activity of peptide derivatives isolated from two species of Leguminosae

Constituents and antiproliferative activity of extracts from leaves of Croton macrobothrys

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