A light-weight and high-efficacy antibacterial nanocellulose-based sponge via covalent immobilization of gentamicin

Xiao, Yihong; Rong, Liduo; Wang, Bijia; Mao, Zhiping; Xu, Hong; Zhong, Yi; Zhang, Linping; Sui, Xiaofeng

doi:10.1016/j.carbpol.2018.07.091

Cited by 41 publications

(28 citation statements)

References 33 publications

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“…Table 5 summarises some examples of the immobilisation of antimicrobial materials inside the NCFs. In the study conducted by Xiao et al [ 123 ], the authors investigated the efficacy of antibacterial nanocellulose-based sponges through the covalent immobilisation of gentamicin. The result obtained revealed that the incorporation of 0.33 wt% gentamicin in the CNF sponge has a non-leaching effect and a durable contact-active antibacterial effect.…”

Section: Cellulose Nanofibre (Cnf) Aerogels In Medical Applicationmentioning

confidence: 99%

A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

et al. 2020

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Cellulose nanomaterials from plant fibre provide various potential applications (i.e., biomedical, automotive, packaging, etc.). The biomedical application of nanocellulose isolated from plant fibre, which is a carbohydrate-based source, is very viable in the 21st century. The essential characteristics of plant fibre-based nanocellulose, which include its molecular, tensile and mechanical properties, as well as its biodegradability potential, have been widely explored for functional materials in the preparation of aerogel. Plant cellulose nano fibre (CNF)-based aerogels are novel functional materials that have attracted remarkable interest. In recent years, CNF aerogel has been extensively used in the biomedical field due to its biocompatibility, renewability and biodegradability. The effective surface area of CNFs influences broad applications in biological and medical studies such as sustainable antibiotic delivery for wound healing, the preparation of scaffolds for tissue cultures, the development of drug delivery systems, biosensing and an antimicrobial film for wound healing. Many researchers have a growing interest in using CNF-based aerogels in the mentioned applications. The application of cellulose-based materials is widely reported in the literature. However, only a few studies discuss the potential of cellulose nanofibre aerogel in detail. The potential applications of CNF aerogel include composites, organic–inorganic hybrids, gels, foams, aerogels/xerogels, coatings and nano-paper, bioactive and wound dressing materials and bioconversion. The potential applications of CNF have rarely been a subject of extensive review. Thus, extensive studies to develop materials with cheaper and better properties, high prospects and effectiveness for many applications are the focus of the present work. The present review focuses on the evolution of aerogels via characterisation studies on the isolation of CNF-based aerogels. The study concludes with a description of the potential and challenges of developing sustainable materials for biomedical applications.

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Section: Cellulose Nanofibre (Cnf) Aerogels In Medical Applicationmentioning

confidence: 99%

A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

et al. 2020

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“…The absorption of water sharply decreased from 112.1 mL g −1 to 5.3 mL g −1 , however, the absorption of chloroform decreased moderately from 100.8 mL g −1 to 63.6 mL g −1 . The study of gentamicin‐modified CNFs–cellulosic acetoacetate–3‐animopropyl(triethoxy)silane (CNFs–CAA–APTES) sponges also confirmed that the cross‐linked CNFs materials became more hydrophobic, with water adsorption decreasing from 8500 % to 5935 % . The increased hydrophobicity of the cross‐linked aerogels made them more stable in aqueous media and showed the potential to be applied in aqueous conditions such as an efficient and effective filter to separate water and organic solvent.…”

Section: Covalently Linked Nanocellulose Materialsmentioning

confidence: 99%

“…[20] The study of gentamicin-modified CNFs-cellulosic acetoacetate-3-animopropyl(triethoxy)silane (CNFs-CAA-APTES) sponges also confirmed that the cross-linked CNFs materials becamem ore hydrophobic,w ith water adsorption decreasingf rom 8500% to 5935%. [30] The increased hydrophobicity of the cross-linked aerogels made them more stable in aqueous media and showed the potentialt ob ea ppliedi n aqueous conditions such as an efficient and effective filter to separatew ater and organic solvent. Moreover, the thermals tability also significantly improved with cross-linking.…”

Section: Amide Linkagesmentioning

confidence: 99%

Cross‐Linked Nanocellulosic Materials and Their Applications

Liang

Bhagia

et al. 2019

ChemSusChem

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Nanocelluloses (NCs) have remarkable mechanical properties and contain abundant surface functional groups that can be modified or cross‐linked with other materials. They have been widely used as an environment‐friendly reinforcing agent in polymer composites. However, for applications that are carried out in humid environments or aqueous suspensions, hydrophilicity of NCs lower their mechanical integrity. Hence, cross‐linking techniques have been investigated in recent years for preparing NC‐based materials that are dimensionally stable under humid or aqueous environments and have better physicochemical properties. This Minireview examines the quickly growing field of cross‐linked NC‐based materials, which have many benefits including improved aqueous, structural, mechanical, and thermal stability. In addition, the potential application of cross‐linked NC‐based materials in adsorption of heavy metal is discussed.

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“…Tactile sensor (simultaneous sensing of temperature and pressure) [126] Strain-sensing protonated aerogels from cellulose nanofibrils [127] Drug delivery Peroral Paracetamol [49] Ibuprofen (colonic release) [70] Methotrexate (colonic release) [128] Transdermal Analgesics, antiphlogistics, corticoids, antihypertensives [50,51] Diclophenac [129] Propranolol [130] Topical Local anesthetics [131] Antiseptics [132,133] Antibiotics (gentamycin, ceftriaxone) [33,43] Antibacterial peptides [134] Other antimicrobial, antiinflammatory and antitumor drugs [135,136] 183…”

Section: Lithium Batteriesmentioning

confidence: 99%

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

Bacakova¹,

Pajorová²,

Bačáková³

et al. 2018

Preprint

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Nanocellulose is cellulose in the form of nanostructures, i.e. features not exceeding 100 nm at least in one dimension. These nanostructures include nanofibrils, e.g. in bacterial cellulose; nanofibers, e.g. in electrospun matrices; nanowhiskers and nanocrystals. These structures can be further assembled into bigger 2D and 3D nano-, micro- and macro-structures, such as nanoplatelets, membranes, films, microparticles and porous macroscopic matrices. There are four main sources of nanocellulose: bacteria (Gluonacetobacter), plants (trees, shrubs, herbs), algae (Cladophora) and animals (Tunicata). Nanocellulose has emerged for a wide range of industrial, technology and biomedical applications, e.g. for adsorption, ultrafiltration, packaging, conservation of historical artifacts, thermal insulation and fire retardation, energy extraction and storage, acoustics, sensorics, controlled drug delivery, and particularly for tissue engineering. Nanocellulose is promising for use in scaffolds for engineering of blood vessels, neural tissue, bone, cartilage, liver, adipose tissue, urethra and dura mater, for repairing connective tissue and congenital heart defects, and for constructing contact lenses and protective barriers. This review is focused on applications of nanocellulose in skin tissue engineering and wound healing as a scaffold for cell growth, for delivering cells into wounds, and as a material for advanced wound dressings coupled with drug delivery, transparency and sensorics. Potential cytotoxicity and immunogenicity of nanocellulose are also discussed.

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A light-weight and high-efficacy antibacterial nanocellulose-based sponge via covalent immobilization of gentamicin

Cited by 41 publications

References 33 publications

A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

A Review on Plant Cellulose Nanofibre-Based Aerogels for Biomedical Applications

Cross‐Linked Nanocellulosic Materials and Their Applications

Nanocellulose in Biotechnology and Medicine: Focus on Skin Tissue Engineering and Wound Healing

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