A label-free ultrasensitive microfluidic surface Plasmon resonance biosensor for Aflatoxin B1 detection using nanoparticles integrated gold chip

Bhardwaj, Hema; Sumana, Gajjala; Marquette, Christophe A.

doi:10.1016/j.foodchem.2019.125530

Cited by 90 publications

(31 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bhardwaj et al developed a SPR-based biosensor using antibodies to detect AFB1. The surface immobilization of anti-AFB1 antibodies by coating with AuNPs amplified the signal and reduced the LOD to 0.003 nM [ 120 ]. Othman and Wollenberger achieved an amperometric biosensor using immobilized laccase as the sensing element in the detection of phenolic NPs.…”

Section: Emerging Biosensor-based Detection Methods Of Natural Producmentioning

confidence: 99%

Emerging biosensors in detection of natural products

Piroozmand

Mohammadipanah

Faridbod

2020

Synthetic and Systems Biotechnology

View full text Add to dashboard Cite

Natural products (NPs) are a valuable source in the food, pharmaceutical, agricultural, environmental, and many other industrial sectors. Their beneficial properties along with their potential toxicities make the detection, determination or quantification of NPs essential for their application. The advanced instrumental methods require time-consuming sample preparation and analysis. In contrast, biosensors allow rapid detection of NPs, especially in complex media, and are the preferred choice of detection when speed and high throughput are intended. Here, we review diverse biosensors reported for the detection of NPs. The emerging approaches for improving the efficiency of biosensors, such as microfluidics, nanotechnology, and magnetic beads, are also discussed. The simultaneous use of two detection techniques is suggested as a robust strategy for precise detection of a specific NP with structural complexity in complicated matrices. The parallel detection of a variety of NPs structures or biological activities in a mixture of extract in a single detection phase is among the anticipated future advancements in this field which can be achieved using multisystem biosensors applying multiple flow cells, sensing elements, and detection mechanisms on miniaturized folded chips.

show abstract

Section: Emerging Biosensor-based Detection Methods Of Natural Producmentioning

confidence: 99%

Emerging biosensors in detection of natural products

Piroozmand

Mohammadipanah

Faridbod

2020

Synthetic and Systems Biotechnology

View full text Add to dashboard Cite

show abstract

“…However, the liquid sample volumes and power consumption of a SPR-based biosensor are still bulky, and the sensitivity and resolution of those SPR-based biosensors or devices need to be further improved, which have been the main bottlenecks in the fabrication of SPR-based biosensors for biomedical applications. To circumvent these drawbacks, nanomaterials, microfluidic devices, and compact as well as power-free pump systems have been attempted to integrate SPR-based biosensor systems [230] , [241] , [242] , [243] , [244] , [245] , [246] , [247] . In one example, an innovative SPR-based biosensor was developed for highly sensitive detection of HIV-related DNA based on entropy-driven strand displacement reactions and double-layer DNA tetrahedrons for SPR signal enhancement ( Fig.…”

Section: Detection Methods For Poc Diagnostic Applicationsmentioning

confidence: 99%

Point-of-care diagnostics for infectious diseases: From methods to devices

et al. 2021

View full text Add to dashboard Cite

show abstract

“…SPR sensors have also been used in diverse healthcare biosensing applications, bioimaging paediatric burns [75] as well as in the study of mutations [76] and the effects of radiation exposure [77]. Recent studies have also shown the versatility of such devices in the study of pathogens [78], thermal injuries [79], carcinogens [80] and several clinically vital molecules [81][82][83].…”

Section: Surface Plasmon Resonance Sensors For Biomedical Diagnosticsmentioning

confidence: 99%

Recent Progress in Optical Sensors for Biomedical Diagnostics

Pirzada

Altıntaş

2020

Micromachines

View full text Add to dashboard Cite

In recent years, several types of optical sensors have been probed for their aptitude in healthcare biosensing, making their applications in biomedical diagnostics a rapidly evolving subject. Optical sensors show versatility amongst different receptor types and even permit the integration of different detection mechanisms. Such conjugated sensing platforms facilitate the exploitation of their neoteric synergistic characteristics for sensor fabrication. This paper covers nearly 250 research articles since 2016 representing the emerging interest in rapid, reproducible and ultrasensitive assays in clinical analysis. Therefore, we present an elaborate review of biomedical diagnostics with the help of optical sensors working on varied principles such as surface plasmon resonance, localised surface plasmon resonance, evanescent wave fluorescence, bioluminescence and several others. These sensors are capable of investigating toxins, proteins, pathogens, disease biomarkers and whole cells in varied sensing media ranging from water to buffer to more complex environments such as serum, blood or urine. Hence, the recent trends discussed in this review hold enormous potential for the widespread use of optical sensors in early-stage disease prediction and point-of-care testing devices.

show abstract

A label-free ultrasensitive microfluidic surface Plasmon resonance biosensor for Aflatoxin B1 detection using nanoparticles integrated gold chip

Cited by 90 publications

References 33 publications

Emerging biosensors in detection of natural products

Emerging biosensors in detection of natural products

Point-of-care diagnostics for infectious diseases: From methods to devices

Recent Progress in Optical Sensors for Biomedical Diagnostics

Contact Info

Product

Resources

About