A hybrid oxygen-generating wound dressing based on chitosan thermosensitive hydrogel and decellularized amniotic membrane

Tehrani, Fatemeh Dadkhah; Shabani, Iman; Shabani, Amir

doi:10.1016/j.carbpol.2021.119020

Cited by 26 publications

(11 citation statements)

References 35 publications

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“…The commonly used oxygen-generating materials possess rapid oxygen release rates, so they are widely used for wound treatment [ 175 , 176 ]. These materials can hardly accelerate the oxygen supply rate according to the hypoxia degree in the damaged area.…”

Section: Applications Of Nanomaterials In Accelerating Fracture Healingmentioning

confidence: 99%

Research advances of nanomaterials for the acceleration of fracture healing

Zhang,

Xu,

Cao

et al. 2024

Bioactive Materials

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Section: Applications Of Nanomaterials In Accelerating Fracture Healingmentioning

confidence: 99%

Research advances of nanomaterials for the acceleration of fracture healing

Zhang,

Xu,

Cao

et al. 2024

Bioactive Materials

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“…The purpose of oxygen therapy is to provide an oxygen-rich microenvironment for wound healing, such as hyperbaric oxygen therapy, which is widely used in clinic. However, due to its limitations, researchers are developing a variety of oxygen-producing biomaterials as a source of oxygen release ( 144 ). Acidic pH enhances acute inflammatory responses by stimulating the migration and aggregation of neutrophils and macrophages, delaying spontaneous apoptosis, and prolonging the functional life of neutrophils ( 145 , 146 ).…”

Section: Role Of the Ecm In The Inflammatory Microenvironmentmentioning

confidence: 99%

Inflammatory Microenvironment of Skin Wounds

et al. 2022

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Wound healing is a dynamic and highly regulated process that can be separated into three overlapping and interdependent phases: inflammation, proliferation, and remodelling. This review focuses on the inflammation stage, as it is the key stage of wound healing and plays a vital role in the local immune response and determines the progression of wound healing. Inflammatory cells, the main effector cells of the inflammatory response, have been widely studied, but little attention has been paid to the immunomodulatory effects of wound healing in non-inflammatory cells and the extracellular matrix. In this review, we attempt to deepen our understanding of the wound-healing microenvironment in the inflammatory stage by focusing on the interactions between cells and the extracellular matrix, as well as their role in regulating the immune response during the inflammatory stage. We hope our findings will provide new ideas for promoting tissue regeneration through immune regulation.

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“…In addition, Zehra et al (2020) fabricated PCL (polycaprolactone)-based oxygen-releasing wound dressings by using peroxide-based oxygen-producing materials [ 40 ]. The oxygen-generating wound dressing designed by Fatemeh et al (2021) was composed of H 2 O 2 -loaded polylactic acid (PLA) microparticles embedded within a chitosan/β-glycerophosphate (β-GP) thermosensitive hydrogel covered with a layer of decellularized human-amniotic membrane(AM) [ 80 ].…”

Section: Hydrogel Dressing Loaded With Nanomedicinesmentioning

confidence: 99%

Current Progress and Outlook of Nano-Based Hydrogel Dressings for Wound Healing

et al. 2022

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Wound dressing is an important tool for wound management. Designing wound dressings by combining various novel materials and drugs to optimize the peri-wound environment and promote wound healing is a novel concept. Hydrogels feature good ductility, high water content, and favorable oxygen transport, which makes them become some of the most promising materials for wound dressings. In addition, nanomaterials exhibit superior biodegradability, biocompatibility, and colloidal stability in wound healing and can play a role in promoting healing through their nanoscale properties or as carriers of other drugs. By combining the advantages of both technologies, several outstanding and efficient wound dressings have been developed. In this paper, we classify nano-based hydrogel dressings into four categories: hydrogel dressings loaded with a nanoantibacterial drug; hydrogel dressings loaded with oxygen-delivering nanomedicines; hydrogel dressings loaded with nanonucleic acid drugs; and hydrogel dressings loaded with other nanodelivered drugs. The design ideas, advantages, and challenges of these nano-based hydrogel wound dressings are reviewed and analyzed. Finally, we envisaged possible future directions for wound dressings in the context of relevant scientific and technological advances, which we hope will inform further research in wound management.

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A hybrid oxygen-generating wound dressing based on chitosan thermosensitive hydrogel and decellularized amniotic membrane

Cited by 26 publications

References 35 publications

Research advances of nanomaterials for the acceleration of fracture healing

Research advances of nanomaterials for the acceleration of fracture healing

Inflammatory Microenvironment of Skin Wounds

Current Progress and Outlook of Nano-Based Hydrogel Dressings for Wound Healing

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