Research advances of nanomaterials for the acceleration of fracture healing

Early‐Responsive Immunoregulation Therapy Improved Microenvironment for Bone Regeneration Via Engineered Extracellular Vesicles

“…Immediately after the bone defect occurs, an acute immune response occurs, and immunocytes, represented by neutrophils, gather around the defect area to play an important role in resisting infection and removing debris. [1,54] The early-stage inflammatory environment has been proven to be conducive to the initiation of bone regeneration. However, excessive inflammation is detrimental to long-term osteogenesis.…”

“…Bone defect, especially large sized bone defect has been a major challenge for orthopedic trauma therapy. [1] Intervention in immune response alters the fate of bone repair. During the early stages of bone defect repair, the inflammatory response involves the activation and recruitment of inflammatory cells, such as macrophages, neutrophils, and T cells, which release inflammatory mediators.…”

A disposable electrochemical caffeine sensor based on a screen-printed electrode modified with a copper-metal organic framework and functionalized multi-walled carbon nanotube nanocomposite

“…Significant improvements in performances have been achieved by using modifying electrodes with carbon nanomaterials, which exhibit high stability, large surface areas, excellent conductivity and good catalytic properties. 9…”

Regulation of metabolic microenvironment with a nanocomposite hydrogel for improved bone fracture healing

“…In recent years, the application of bioactive materials has emerged as a promising approach for modulating the microenvironment and promoting bone fracture healing [ 21 ]. Covalent organic frameworks (COFs) are emerging crystalline porous organic polymers for the sustained delivery of drugs [ 22 ].…”