A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging

Wang, Ting; Wang, Shangfeng; Li, Yong; He, Zuyang; Yu, Peng; Zhao, Mengyao; Zhang, Hongxin; Lu, Lingfei; Wang, Zhengxin; Wang, Ziyu; Zhang, Weian; Fan, Yong; Sun, Chia‐Chung; Zhao, Dongyuan; Liu, Weimin; Bünzli, Jean‐Claude G.; Zhang, Fan

doi:10.1038/s41563-021-01063-7

Cited by 169 publications

(122 citation statements)

References 45 publications

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“…[ 20 ] The photothermal agents are activated in the NIR window allowing for high photothermal conversion rate and deep‐tissue penetration efficiency. [ 21 ] Therefore, it is important that the photothermal agents are effectively activated in the NIR window to maximize the photothermal effects for promoting osteogenesis in deep tissues when applied in bone tissue engineering. Molybdenum disulfide (MoS 2 ) nanosheets are an emerging class of layered 2D metal dichalcogenides with excellent biocompatibility and photothermal conversion efficiency under 808 nm irradiation.…”

Section: Introductionmentioning

confidence: 99%

Tissue‐Engineered Bone Functionalized with MoS₂ Nanosheets for Enhanced Repair of Critical‐Size Bone Defect in Rats

Zhang

Zheng

et al. 2021

Adv Funct Materials

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Tissue-engineered bones have therapeutic potential for critical-size bone defects; however, the production of high quantities of the tissue-engineered bones with osteo-induction ability remains a huge challenge. Hyperthermia has been shown to up-regulate the expression of osteogenesis-related proteins to efficiently to promote bone regeneration. In this study, the authors develop a novel photothermal tissueengineered bone (PTEB) with osteoinduction ability and a biomimetic cellular environment. PTEB is generated by seeding rat bone mesenchymal stem cells (rBMMSCs) in the photothermal MoS 2 -biotin-garose-gelatin scaffold, and then overlaying the scaffold using osteo-induction extracellular matrix (OiECM). The rBMMSCs act as seeding cells, while OiECM provide a biomimetic microenvironment for repairing critical-sized cranial defects in rats. The results show that the PTEB exhibit high biocompatibility and osteo-induction ability under near-infrared (NIR) radiation. Results of in vitro experiments show that PTEB under NIR radiation promote proliferation and osteogenic differentiation of rBMMSCs. Furthermore, the PTEB implantation under NIR radiation significantly induces regeneration of bone in critical-size bone defects in rats 12 weeks after implantation. These findings indicate that PTEB has great potential in regenerative medicine and may represent an effective replacement for autografts used commonly in bone tissue engineering.

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Section: Introductionmentioning

confidence: 99%

Tissue‐Engineered Bone Functionalized with MoS₂ Nanosheets for Enhanced Repair of Critical‐Size Bone Defect in Rats

Zhang

Zheng

et al. 2021

Adv Funct Materials

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“…Therefore, the multi-channel imaging techniques and multi-response probes should be developed for NIR-II in vivo quantitative analysis. Multi-response NIR-II probes can respond to different analytes and have differentiable signals for various analytes, and the real-time multi-channel NIR-II imaging techniques can simultaneously record multiple events ( Fan et al, 2018 ; Cao J. et al, 2019 ; Wang T. et al, 2021 ; Shinn et al, 2021 ), providing more in vivo quantitative properties for understanding the physiological and pathological processes of living bodies.…”

Section: Perspectives and Challengesmentioning

confidence: 99%

Near-Infrared-II Bioimaging for in Vivo Quantitative Analysis

et al. 2021

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Near-Infrared-II (NIR-II) bioimaging is a newly emerging visualization modality in real-time investigations of biological processes research. Owning to advances in reducing photon scattering and low tissue autofluorescence levels in NIR-II region (1,000–1700 nm), NIR-II bioimaging affords high resolution with increasing tissue penetration depth, and it shows greater application potential for in vivo detection to obtain more detailed qualitative and quantitative parameters. Herein, this review summarizes recent progresses made on NIR-II bioimaging for quantitative analysis. These emergences of various NIR-II fluorescence, photoacoustic (PA), luminescence lifetime imaging probes and their quantitative analysis applications are comprehensively discussed, and perspectives on potential challenges facing in this direction are also raised.

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“…Furthermore, due to the advantages of low photon scattering and autofluorescence for deep tissue penetration and high spatial resolution, fluorescence imaging in the second-near infrared window (NIR-II, 1000~1700 nm) has recently attracted extensive attention [10][11][12][13][14][15][16] . Thus, NIR-II imaging has been applied for in vivo visualizations of the vasculature, organs, tumors, and GI tract [17][18][19][20][21] .…”

Section: Introductionmentioning

confidence: 99%

High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice

Guan

Zhang

et al. 2022

Nano Lett.

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Conventional biomedical imaging modalities, including endoscopy, X-rays, and magnetic resonance, are invasive and cannot provide sufficient spatial and temporal resolutions for regular imaging of gastrointestinal (GI) tract to guide prognosis and therapy of GI diseases.Here we report a non-invasive method for optical imaging of GI tract. It is based on a new type of lanthanide-doped nanocrystal with near-infrared (NIR) excitation at 980 nm and second NIR window (NIR-IIb) (1500~1700 nm) fluorescence emission at around 1530 nm. The rational design and controlled synthesis of nanocrystals with high brightness have led to an absolute quantum yield (QY) up to 48.6%. Further benefitting from the minimized scattering through the NIR-IIb window, we enhanced the spatial resolution by 3 times compared with the other NIR-IIa (1000~1500 nm) contract agents for GI tract imaging. The approach also led to a high temporal resolution of 8 frames per second, so that the moment of mice intestinal peristalsis happened in one minute can be captured. Furthermore, with a light-sheet imaging system, we demonstrated a three-dimensional (3D) imaging of the stereoscopic structure of the GI tract.Moreover, we successfully translate these advances to diagnose inflammatory bowel disease (IBD) in a pre-clinical model of mice colitis.

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A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging

Cited by 169 publications

References 45 publications

Tissue‐Engineered Bone Functionalized with MoS₂ Nanosheets for Enhanced Repair of Critical‐Size Bone Defect in Rats

Tissue‐Engineered Bone Functionalized with MoS₂ Nanosheets for Enhanced Repair of Critical‐Size Bone Defect in Rats

Near-Infrared-II Bioimaging for in Vivo Quantitative Analysis

High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice

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A hybrid erbium(III)–bacteriochlorin near-infrared probe for multiplexed biomedical imaging

Cited by 169 publications

References 45 publications

Tissue‐Engineered Bone Functionalized with MoS2 Nanosheets for Enhanced Repair of Critical‐Size Bone Defect in Rats

Tissue‐Engineered Bone Functionalized with MoS2 Nanosheets for Enhanced Repair of Critical‐Size Bone Defect in Rats

Near-Infrared-II Bioimaging for in Vivo Quantitative Analysis

High Spatial and Temporal Resolution NIR-IIb Gastrointestinal Imaging in Mice

Contact Info

Product

Resources

About

Tissue‐Engineered Bone Functionalized with MoS₂ Nanosheets for Enhanced Repair of Critical‐Size Bone Defect in Rats

Tissue‐Engineered Bone Functionalized with MoS₂ Nanosheets for Enhanced Repair of Critical‐Size Bone Defect in Rats