A human prostatic growth factor (hPGF): Partial purification and characterization

Nishi, Nozomu; Matuo, Yuhsi; Muguruma, Yasuyoshi; Yoshitake, Yoshino; Nishikawa, Katsuzo; Wada, Fumio

doi:10.1016/0006-291x(85)91920-5

Cited by 48 publications

(22 citation statements)

References 12 publications

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“…One of the fi rst growth factors isolated from BPH tissue was FGF-2 or basic FGF [ 8 ]. FGF-2 is synthesized in, and has been shown to be mitogenic for, normal prostatic stromal cells [ 6 , 9 ].…”

Section: Fibroblast Growth Factor-2 (Basic Fi Broblast Growth Factor)mentioning

confidence: 77%

Growth factors in benign prostatic hyperplasia: Basic science implications

Lucia

Lambert²

2008

Curr Urol Rep

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Benign prostatic hyperplasia (BPH) is the most common proliferative disease of the prostate of men in the United States. The histopathology of BPH strongly implicates local paracrine and autocrine growth factors and inflammatory cytokines in its pathogenesis. A complex milieu of growth-regulatory proteins includes members of the fibroblast, insulin-like, and transforming growth factor families. It appears that these proteins and downstream effector molecules, in addition to a variety of interleukins, are overexpressed in BPH and, working together, create a landscape of increased stromal and epithelial growth and mesenchymal transdifferentiation that leads to disease progression. Inflammation, commonly present in BPH, may contribute to tissue injury, and cytokines produced by inflammatory cells may serve to drive local growth factor production and angiogenesis in the tissues as a "wound healing" response. As we begin to unravel the precise mechanisms involved, new treatments for BPH aimed at these interacting pathways may emerge.

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Section: Fibroblast Growth Factor-2 (Basic Fi Broblast Growth Factor)mentioning

confidence: 77%

Growth factors in benign prostatic hyperplasia: Basic science implications

Lucia

Lambert²

2008

Curr Urol Rep

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“…Endothelial cell growth factors, which are important in the regulation of angiogenesis, have been isolated from various normal tissue extracts (1,2,(8)(9)(10)24) and from tumor cell exracts (7,8). Most of these factors share the nature of specific binding with a high affinity to heparin, and are divided into two closely related groups, acidic fibroblast growth factor (a-FGF) and basic fibroblast growth factor (b-FGF) (9,(18)(19)(20).…”

mentioning

confidence: 99%

Characterization of a new endothelial cell growth factor (f-ECGF) partially purified from the supernatant of human fibroblast cells.

Satoh¹,

Kan

Masuko³

et al. 1989

Cell Struct. Funct.

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ABSTRACT. A new endothelial cell growth factor (f-ECGF) was partially purified from the cultured medium of human fibroblast cells of embryonic lungs. The partially purified f-ECGF induced neovascularization in rabbit cornea. It showed a selective growth stimulatory activity on the endothelial cells in vitro, whereas acidic-and basic-fibroblast growth factors (a-and b-FGFs) showed a broad spectrum of growth stimulation among tissues or cells. f-ECGF did not compete with the binding of a-FGF to the cell surface receptor in HEP-G2 hepatoblastoma cell lines. These results indicated that f-ECGF is a new endothelial cell growth factor distinct from a-and b-FGFs which are known to be potent endothelial cell growth factors.

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“…The GF activity was determined as the stimulating activity of DNA synthesis according to the method of Nishi et al [15], as follows.…”

Section: Measurement Of Gf Activity In the Dlpmentioning

confidence: 99%

Effects of mepartricin, a polyene macrolide antibiotic, on estrogen-induced hyperplastic growth of the dorsolateral prostate and seminal vesicle in immature castrated rats

Shakuto

Tsuchiya

2005

Scandinavian Journal of Urology and Nephrology

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A human prostatic growth factor (hPGF): Partial purification and characterization

Cited by 48 publications

References 12 publications

Growth factors in benign prostatic hyperplasia: Basic science implications

Growth factors in benign prostatic hyperplasia: Basic science implications

Characterization of a new endothelial cell growth factor (f-ECGF) partially purified from the supernatant of human fibroblast cells.

Effects of mepartricin, a polyene macrolide antibiotic, on estrogen-induced hyperplastic growth of the dorsolateral prostate and seminal vesicle in immature castrated rats

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