“…Besides their poor solubility in water, many uorescent sensors are being used to detect Al 3+ in live cells, Drosophila melanogaster, Escherichia coli, zebrash, rice seedlings, etc. [33][34][35][36][37][38][39] However, the utilization of organic solvents for cellular imaging can destroy the cells, causing inaccurate sensing of intracellular Al 3+ . Therefore, the development of water-soluble uorescent Al 3+ sensors would effectively enhance the efficiency of detection to the next level.…”