A highly selective colorimetric and fluorescent probe for quantitative detection of Cu2+/Co2+: The unique ON-OFF-ON fluorimetric detection strategy and applications in living cells/zebrafish

A Coumarin-Based Fluorescent Probe for Ratiometric Detection of Cu2+ and Its Application in Bioimaging

“…Compounds 1-3 were gained according to the previous work (Ma et al, 2004 ; Yu et al, 2011 ; Tanaka et al, 2019 ; Wang P. et al, 2020 ; Wang Z. G. et al, 2020 ). Then compound 3 (1 mmol, 304 mg) and 1.8-naphthalic anhydride (1 mmol, 198 mg) were dissolved in 25 mL DMF and heated to reflux for 6 h. After the reaction was complete, the reaction mixture was cooled to room temperature and poured into ice water to separate the solid.…”

“…As is known to all, copper ion (Cu 2+ ) occupies an important place in a variety of fundamental physiological processes in organisms ranging from bacteria to mammals (Huang et al, 2014 ; Arjmand et al, 2018 ; Wang P. et al, 2018 ; Wang Y. et al, 2018 ; Zeng et al, 2019 ; Aydin et al, 2020 ; Wang Z. G. et al, 2020 ). However, Cu 2+ can also lead to environmental pollution because it has been used widely in industrial and agricultural processes (Huang et al, 2014 ; Zhang et al, 2016 ; Gu et al, 2018 ; Wang et al, 2019 ; Zhu et al, 2020 ).…”

Small molecule sensors for the colorimetric detection of Copper(II): A review of the literature from 2010 to 2022

“…A Schiff-base in the form of acylhydrazine derivative was utilized for metal ion coordination. Wang (2020) et al [40] synthesized a coumarin-appended naphthohydrazide 4 "onoff" sensor by condensation of 7-diethylaminocoumarine-3-aldehyde and 3-hydroxy-2naphthohydrazide (Table 1 Sensor #4). Fluorescent sensor 4 (2.5 µM) could recognize 1 equivalent of Cu 2+ and Co 2+ selectively over a wide range of biologically and environmentally relevant metal ions in EtOH:10 mM phosphate buffer (7:13, v/v, pH = 7.2), with a color change from green to colorless under UV light, and from yellow to orange-red under ambient light.…”

“…Flow analysis quantitatively proved this quenching in MCF-7 cells. Reproduced from Wang(2020) et al [40].…”

The Synthesis of 2,2-BIS(1-INDOL-3-YL)Acenaphthylene-1(2)-Ones Using Nanocatalysis: Fluorescent Sensing for Cu2+ Ions

“…As well as the bis-indole derivatives have optical properties, which can detect via numerous methods in various environments containing inorganic ions and heavy metals (Fig. 2) [77][78][79]. Consequently, the other bis-indole derivative can function as a medicinal sensor to detect toxic and hazardous materials in biological and blood samples.…”