A High Throughput Lab-On-A-Chip System for Label Free Quantification of Breast Cancer Cells under Continuous Flow

Aslan, Melis; Yalçın, Yağmur Demircan; Özgür, Ebru; Gündüz, Ufuk; Eminoglu, Selim; Külah, Haluk; Akın, Tayfun

doi:10.1016/j.protcy.2017.04.028

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…[ 147 ] Cabibbe et al designed a customizable array of LOC devices for the detection of multidrug‐resistant tuberculosis [ 148 ] based on PCR. Aslan et al [ 149 ] designed an LOC device for the detection of breast cancer using a complementary metal oxide semiconductor image sensor that can count the cancerous cells requiring only 130 μL min −1 fluid through the channel. Several blood cross matching tests were carried out by a finger‐actuated LOC [ 150 ] where 50 μL amount of blood samples were used to separate the blood and plasma by a membrane for cross‐matching.…”

Section: Next‐generation Microfluidicsmentioning

confidence: 99%

Microfluidics: Recent Advances Toward Lab‐on‐Chip Applications in Bioanalysis

Sharma

2021

Adv Eng Mater

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Microfluidics is an emerging technology of flow and control of fluids in microscale volume that offers highly specialized solutions to rapid, sensitive, noninvasive analysis and measurements in various engineering applications. When combined with microelectromechanical systems (MEMSs), microfluidics technology has shown remarkable developments in small‐scale devices for biosensing, chemical solutions, and precise detection of particles at a higher rate. MEMS‐inspired microfluidics technology can contribute to the highly sensitive, recyclable, and portable sensing platforms for large‐scale integration devices. In this review, the history and developmental phases occurring in MEMS are detailed. Finally, this review is concluded with future scope and guidelines for enabling the various approaches to overcome the obstacles and the mass commercialization of microfluidic devices. Recent applications of microfluidics in biosensing are also highlighted where research should be focused in the future.

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Section: Next‐generation Microfluidicsmentioning

confidence: 99%

Microfluidics: Recent Advances Toward Lab‐on‐Chip Applications in Bioanalysis

Sharma

2021

Adv Eng Mater

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“…The designs and applications go in various directions—for example, injection-molded polymeric LOC for blood plasma separation [ 1 ], plastic LOC for herbicide residue monitoring in soil [ 2 ], and devices for the detection of various pathogens in food [ 3 , 4 ], for the detection of viruses [ 5 , 6 ], and for the detection of bacteria [ 7 ]. The applications of LOC devices do not end here; they could be used for research on various cells, such as research on the growth of fungal cultures [ 8 ] or on cancer and tumor cells [ 9 , 10 , 11 ]. LOC devices could also be used for tissue or organ research.…”

Section: Introductionmentioning

confidence: 99%

Combined Femtosecond Laser Glass Microprocessing for Liver-on-Chip Device Fabrication

Butkutė

Jurkšas²,

Baravykas³

et al. 2023

Materials

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Nowadays, lab-on-chip (LOC) devices are attracting more and more attention since they show vast prospects for various biomedical applications. Usually, an LOC is a small device that serves a single laboratory function. LOCs show massive potential for organ-on-chip (OOC) device manufacturing since they could allow for research on the avoidance of various diseases or the avoidance of drug testing on animals or humans. However, this technology is still under development. The dominant technique for the fabrication of such devices is molding, which is very attractive and efficient for mass production, but has many drawbacks for prototyping. This article suggests a femtosecond laser microprocessing technique for the prototyping of an OOC-type device—a liver-on-chip. We demonstrate the production of liver-on-chip devices out of glass by using femtosecond laser-based selective laser etching (SLE) and laser welding techniques. The fabricated device was tested with HepG2(GS) liver cancer cells. During the test, HepG2(GS) cells proliferated in the chip, thus showing the potential of the suggested technique for further OOC development.

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“…Microfluidic chips are extensively applied in in-vitro biomedical models because of their flexibility, such as having control over fluid and gas flow, and a chip architecture able to replace the classical 2D and 3D cell cultures [1]. Many organ models were established in recent years, based on the microfluidic platform, such as brain-on-a-chip, liver-on-a-chip, lung-on-a-chip, and breast-on-a-chip [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. Body-on-a-chip is designed to include more than one organ on one chip [20].…”

Section: Introductionmentioning

confidence: 99%

The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review

Song

et al. 2020

Micromachines

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Microfluidic systems have been widely explored based on microfluidic technology, and it has been widely used for biomedical screening. The key parts are the fabrication of the base scaffold, the construction of the matrix environment in the 3D system, and the application mechanism. In recent years, a variety of new materials have emerged, meanwhile, some new technologies have been developed. In this review, we highlight the properties of high throughput and the biomedical application of the microfluidic chip and focus on the recent progress of the fabrication and application mechanism. The emergence of various biocompatible materials has provided more available raw materials for microfluidic chips. The material is not confined to polydimethylsiloxane (PDMS) and the extracellular microenvironment is not limited by a natural matrix. The mechanism is also developed in diverse ways, including its special physical structure and external field effects, such as dielectrophoresis, magnetophoresis, and acoustophoresis. Furthermore, the cell/organ-based microfluidic system provides a new platform for drug screening due to imitating the anatomic and physiologic properties in vivo. Although microfluidic technology is currently mostly in the laboratory stage, it has great potential for commercial applications in the future.

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A High Throughput Lab-On-A-Chip System for Label Free Quantification of Breast Cancer Cells under Continuous Flow

Cited by 6 publications

References 4 publications

Microfluidics: Recent Advances Toward Lab‐on‐Chip Applications in Bioanalysis

Microfluidics: Recent Advances Toward Lab‐on‐Chip Applications in Bioanalysis

Combined Femtosecond Laser Glass Microprocessing for Liver-on-Chip Device Fabrication

The Fabrication and Application Mechanism of Microfluidic Systems for High Throughput Biomedical Screening: A Review

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