A high-speed, flexible-scanning chemical imaging system using a light-addressable potentiometric sensor integrated with an analog micromirror

Das, Anirban; Chen, Tsung-Cheng; Yang, Chia−Ming; Lai, Chao−Sung

doi:10.1016/j.snb.2014.03.028

Cited by 29 publications

(19 citation statements)

References 25 publications

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“…The average pH sensitivities evaluated at a constant photocurrent of 20 nA were 150 mV/pH under reverse bias (Figure 4c) and 79.4 mV/pH under forward bias (Figure 4d), respectively, which were much higher than that of the traditional silicon‐based LAPS. [ 27c,31 ] The pH sensitivities both under reverse and forward biases exceed the Nernst limit of 59 mV/pH, that may be due to the pH dependent kinetics of the anodic oxidation and cathode reduction processes, respectively. [ 25 ] As shown in Figures 2a and 2b, the C 60 ‐based LAPS showed a combination of capacitive current and photocatalytic redox current both at reverse and forward bias voltages.…”

Section: Resultsmentioning

confidence: 99%

Bipolar Light‐Addressable Potentiometric Sensor Based on Fullerene Photosensitive Layer

Jiao

Zhang

et al. 2021

Adv Materials Technologies

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Light‐addressable potentiometric sensor (LAPS) is highly attractive in many sectors, including human disease detection, drug screening, and environmental monitoring. Currently, classical LAPS chips adopt inorganic semiconductors, such as silicon, as the photosensitive layer. Organic semiconductors can provide the next generation of the photosensitive layer because of their high absorption efficiency, large structural variability, eco‐friendliness, and bendability. However, no promising organic materials have been reported so far for the construction of LAPS chips. Here, the authors demonstrate the potential of fullerene (C60), a π‐conjugated carbon molecule with high n‐type conduction, as a candidate material for the photosensitive layer of LAPS. They report on a peculiar bipolar photo‐response under both reverse and forward biased conditions for C60‐based LAPS. An oxygen‐trap‐induced space‐charge mechanism is proposed to explain the unique bipolar photo‐response phenomenon. The proposed C60‐based LAPS exhibits an excellent pH sensitivity of 150 mV/pH as well as a high spatial resolution of 3.8 µm. The authors anticipate that these results will spark interest in this field and enable the replacement of the inorganic‐semiconductor photosensitive layer by organic semiconductor materials for the construction of high‐performance LAPS.

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Section: Resultsmentioning

confidence: 99%

Bipolar Light‐Addressable Potentiometric Sensor Based on Fullerene Photosensitive Layer

Jiao

Zhang

et al. 2021

Adv Materials Technologies

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“…An analog micromirror based on micro-electro-mechanical systems (MEMS) has been used to replace the traditional mechanical stage [122,123,124]. The schematic of this set-up is shown in Figure 6a, the light spot can be moved and located precisely on the back of the sensor plate according to user requirements by PC software control.…”

Section: Temporal Resolutionmentioning

confidence: 99%

Recent Developments of High-Resolution Chemical Imaging Systems Based on Light-Addressable Potentiometric Sensors (LAPSs)

Liang

Qiu

Gan

et al. 2019

Sensors

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A light-addressable potentiometric sensor (LAPS) is a semiconductor electrochemical sensor based on the field-effect which detects the variation of the Nernst potential on the sensor surface, and the measurement area is defined by illumination. Thanks to its light-addressability feature, an LAPS-based chemical imaging sensor system can be developed, which can visualize the two-dimensional distribution of chemical species on the sensor surface. This sensor system has been used for the analysis of reactions and diffusions in various biochemical samples. In this review, the LAPS system set-up, including the sensor construction, sensing and substrate materials, modulated light and various measurement modes of the sensor systems are described. The recently developed technologies and the affecting factors, especially regarding the spatial resolution and temporal resolution are discussed and summarized, and the advantages and limitations of these technologies are illustrated. Finally, the further applications of LAPS-based chemical imaging sensors are discussed, where the combination with microfluidic devices is promising.

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“…By switching the angles of individual micromirrors reflecting the light, a huge number of pixels on the sensor plate can be individually addressed. Das et al (67) employed 2-axis scanning micromirrors for rapid scanning of the sensor plate with a laser beam. A chemical image with 500 × 400 pixels was scanned in 40 s. Taking advantage of the large number of pixels, a zoom-in function was demonstrated both in a DMD-based system (68) and in a scanning-micromirror-based system.…”

Section: Correction Of Artifact Signalmentioning

confidence: 99%

Development and Bio-imaging Applications of a Chemical Imaging Sensor

2016

Sensors and Materials

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A chemical imaging sensor is a field-effect-based semiconductor sensor, capable of label-free imaging of ion distributions in a solution. The sensor has attracted much interest owing to its simple structure and diverse fields of application of bioimaging. In this article, the principle and development of the chemical imaging sensor are summarized, compared with those of other labelfree imaging sensors. Bio-imaging applications of the chemical imaging sensor to ion diffusion, enzymatic reaction, and metabolic activities of microorganisms are also reviewed.

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A high-speed, flexible-scanning chemical imaging system using a light-addressable potentiometric sensor integrated with an analog micromirror

Cited by 29 publications

References 25 publications

Bipolar Light‐Addressable Potentiometric Sensor Based on Fullerene Photosensitive Layer

Bipolar Light‐Addressable Potentiometric Sensor Based on Fullerene Photosensitive Layer

Recent Developments of High-Resolution Chemical Imaging Systems Based on Light-Addressable Potentiometric Sensors (LAPSs)

Development and Bio-imaging Applications of a Chemical Imaging Sensor

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