Recent Developments of High-Resolution Chemical Imaging Systems Based on Light-Addressable Potentiometric Sensors (LAPSs)

Liang, Tao; Qiu, Yiwei; Gan, Ying; Sun, Jiadi; Zhou, S. P.; Wan, Hao; Wang, Ping

doi:10.3390/s19194294

Cited by 22 publications

(14 citation statements)

References 142 publications

(239 reference statements)

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“…Then, the pH value is converted to a gray value corresponding to the image. According to this method, the remaining positions of the substrate of the LAPS are irradiated in a certain order, and finally, the chemical distribution image of the solution pH value can be obtained ( Liang et al, 2019a ).…”

Section: Principlementioning

confidence: 99%

Light-Addressable Potentiometric Sensors in Microfluidics

Liu

Tan

et al. 2022

Front. Bioeng. Biotechnol.

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The light-addressable potentiometric sensor (LAPS) is an electrochemical sensor based on the field-effect principle of semiconductors. It is able to sense the change of Nernst potential on the sensor surface, and the measuring area can be controlled by the illumination of a movable light. Due to the unique light-addressable ability of the LAPS, the chemical imaging system constructed with the LAPS can realize the two-dimensional image distribution detection of chemical/biomass. In this review, the advantages of the LAPS as a sensing unit of the microelectrochemical analysis system are summarized. Then, the most recent advances in the development of the LAPS analysis system are explained and discussed. In particular, this review focused on the research of ion diffusion, enzymatic reaction, microbial metabolism, and droplet microfluidics using the LAPS analysis system. Finally, the development trends and prospects of the LAPS analysis system are illustrated.

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Section: Principlementioning

confidence: 99%

Light-Addressable Potentiometric Sensors in Microfluidics

Liu

Tan

et al. 2022

Front. Bioeng. Biotechnol.

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“…Then, the pH value is converted to a gray value corresponding to the image. According to this method, the remaining positions of the substrate of LAPS are irradiated in a certain order, and finally the chemical distribution image of solution pH value can be obtained [22] .…”

Section: Chemical Imaging Principle Of Lapsmentioning

confidence: 99%

Light-Addressable Potentiometric Sensors in Microfluidics

li¹,

liu²,

Tan³

et al. 2021

Preprint

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Light-addressable potentiometric sensor (LAPS) is an electrochemical sensor based on the field-effect principle of semiconductor. It is able to sense the change of Nernst potential on the sensor surface, and the measuring area can be controlled by the illumination. Due to the unique light-addressable ability of LAPS, the chemical imaging system constructed with LAPS can realize the two-dimensional image distribution detection of chemical/biomass. In this paper, the advantages of LAPS as sensing unit of microelectrochemical analysis system are summarized. Then, the greatest development of LAPS analysis system is explained and discussed. Especially, this paper focused on the research of ion diffusion, enzymatic reaction, microbial metabolism and droplet microfluidics by using LAPS analysis system. Finally, the development trends and prospects of LAPS analysis system are illustrated.

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“…Light-addressable potentiometric sensor (LAPS) [76] is a surface potential detector, using the beam scanning addressing method to measure the photocurrent response at any point on the silicon wafer, which enables to overcome the problem of limited active sites. [77] By adjusting the light spot diameter, the extracellular potential of the single electrogenic cell including neuron and cardiomyocyte coupled to the LAPS surface can be measured. [78,79] In addition to the spontaneous action potentials of cardiomyocytes, researchers have also demonstrated that the cell shape changes of cardiomyocytes during mechanical contractions could modulate the photocurrents of LAPS.…”

Section: Light Addressable Potentiometric Sensor (Laps)mentioning

confidence: 99%

Advances in Multidimensional Cardiac Biosensing Technologies: From Electrophysiology to Mechanical Motion and Contractile Force

Wei

Zhuang

et al. 2020

Small

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Cardiovascular disease (CVD) is the number one killer in the world. According to the World Health Organization (WHO) estimation, about 17.9 million people died from CVD each year, accounting for 31% of all deaths worldwide. [1] Among these deaths, about 7.4 million died from coronary heart disease, while 6.7 million from a stroke. According to China cardiovascular disease report in 2018, [2] around 290 million people suffer from CVD, including 13 million strokes, 11 million coronary heart disease, 5 million pulmonary heart disease, 4.5 million heart failure, 2.5 million rheumatic heart disease, 2 million congenital heart disease, and 270 million hypertension. Cardiovascular disease was also the leading cause of all death in rural and urban areas, with 45.01% in rural areas and 42.61% in urban areas. According to heart disease and stroke statistics from the American Heart Association (AHA) in 2018, [3] around 92.1 million American adults have a certain form of cardiovascular disease or suffer from stroke sequelae. CVD killed 836546 Americans in 2015. Coronary heart disease was the leading cause (43.8%) of death in CVD, followed by stroke (16.8%), heart failure (9.0%), hypertension (9.4%), arterial disease (3.1%) and other cardiovascular diseases (17.9%). According to the European cardiovascular disease statistics in 2017, [4] around 3.9 million people died from CVD each year, which accounts for 45% of all deaths in Europe. Ischemic heart disease (IHD) and stroke are the main forms of CVD in Europe. Among all deaths in Europe each year, IHD is the leading single cause of mortality, responsible for 19% and 20% among men and women, while stroke is the second most common single cause of death, accounting for 9% in men and 13% in women. Therefore, the prevention and treatment of CVD have aroused extensive public concern worldwide. Moreover, cardiac toxicity induced by drugs has been the main cause of the withdrawal from the market and drugs attrition during the last decades. [5,6] On the one hand, drug-induced cardiotoxicity will also threaten people's health, even life. For example, acute arrhythmia can lead to sudden death, while Cardiovascular disease is currently a leading killer to human, while druginduced cardiotoxicity remains the main cause of the withdrawal and attrition of drugs. Taking clinical correlation and throughput into account, cardiomyocyte is perfect as in vitro cardiac model for heart disease modeling, drug discovery, and cardiotoxicity assessment by accurately measuring the physiological multiparameters of cardiomyocytes. Remarkably, cardiomyocytes present both electrophysiological and biomechanical characteristics due to the unique excitation-contraction coupling, which plays a significant role in studying the cardiomyocytes. This review mainly focuses on the recent advances of biosensing technologies for the 2D and 3D cardiac models with three special properties: electrophysiology, mechanical motion, and contractile force. These high-performance multidimensional cardiac models are popular and ef...

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Recent Developments of High-Resolution Chemical Imaging Systems Based on Light-Addressable Potentiometric Sensors (LAPSs)

Cited by 22 publications

References 142 publications

Light-Addressable Potentiometric Sensors in Microfluidics

Light-Addressable Potentiometric Sensors in Microfluidics

Light-Addressable Potentiometric Sensors in Microfluidics

Advances in Multidimensional Cardiac Biosensing Technologies: From Electrophysiology to Mechanical Motion and Contractile Force

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