A high level of fatigue among long-term survivors of non-Hodgkin's lymphoma: results from the longitudinal population-based PROFILES registry in the south of the Netherlands

Oerlemans, Simone; Mols, Floortje; Issa, Djamila E.; Pruijt, J.F.M.; Peters, W.; Lybeert, Marnix L.M.; Zijlstra, Wobbe P.; Coebergh, Jan Willem; Poll‐Franse, Lonneke V. van de

doi:10.3324/haematol.2012.064907

Cited by 78 publications

(68 citation statements)

References 42 publications

(53 reference statements)

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“…29 The gradual improvement in prognosis for patients with MCL could indicate that secondary therapies resulted in cure for some of these individuals.…”

Section: Discussionmentioning

confidence: 99%

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Actual prognosis during follow-up of survivors of B-cell non-Hodgkin lymphoma in the Netherlands

et al. 2013

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© F e r r a t a S t o r t i F o u n d a t i o nstage, 16 were obtained routinely from the medical records about 9 months after diagnosis.In addition to passive follow-up via the hospitals, date of death was also retrieved from the Municipal Personal Records Database. Follow-up of vital status was complete until January, 1 st , 2010. For the present study, all patients with mature B-cell NHL newly diagnosed in the period [1989][1990][1991][1992][1993][1994][1995][1996][1997][1998][1999][2000][2001][2002][2003][2004][2005][2006][2007][2008] in the Netherlands were included (n=54,015). Patients with plasma cell neoplasms were excluded. NHL entities were defined according to the World Health Organization classification, 4 th edition. 18 The exact codes used for each entity are described in a previous publication.2 Sufficient patients were available to report the entity-specific conditional relative survival for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL), marginal zone lymphoma (MZL), lymphoplasmacytic lymphoma (LPL), follicular lymphoma (FL), mantle cell lymphoma (MCL), and diffuse large B-cell lymphoma (DLBCL).We also used two major diagnostic subgroups, based on a combination of entities of more or less similar clinical behavior and comparable response to therapies: indolent and aggressive B-cell neoplasms. The entities included in each subgroup are shown in Table 1. Unspecified cases were excluded from these analyses.Patients younger than 15 years and older than 89 years were excluded from the analysis, as were cases diagnosed at autopsy. Patients were divided into four age groups (15-44, 45-59, 60-74, and 75-89 years old). Patients aged 15-29 and 30-44 years were merged, because of the small numbers. Statistical analysesRelative survival is an approximation of disease-specific survival. It is calculated as the absolute survival among cancer patients divided by the expected survival of a comparable group from the general population (same period, age, and gender). Expected survival was calculated from population life tables from the Netherlands, according to the Ederer II method. 19 Period analysis 20,21 was used to provide up-to-date survival estimates; all observations included in the analysis are left-truncated at the beginning of the period of interest, in addition to being right-censored at its end. Furthermore, to enable the estimation of even more up-to-date survival, hybrid analysis was used. 22Five-year relative survival rates were computed for every additional year of survival up to 15 years after diagnosis, conditional on being alive at the beginning of that year (conditional 5-year relative survival, CRS), unadjusted for other variables. Conditional survival was computed according to disease entity, grade, gender, 15-year age group, and stage of disease. For the analysis according to period of diagnosis (1995-2000 versus 2003-2008) conditional 3-year relative survival rates were computed, since follow-up time for patients diagnosed in 2003-2008 was limited. When the CRS pe...

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“…29 The gradual improvement in prognosis for patients with MCL could indicate that secondary therapies resulted in cure for some of these individuals.…”

Section: Discussionmentioning

confidence: 99%

“…27,28 Furthermore, a large proportion of NHL patients reported a high level of fatigue up until 10 years after diagnosis. 29 The gradual improvement in prognosis for patients with MCL could indicate that secondary therapies resulted in cure for some of these individuals.…”

Section: Discussionmentioning

confidence: 99%

Actual prognosis during follow-up of survivors of B-cell non-Hodgkin lymphoma in the Netherlands

et al. 2013

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“…We recently published separate papers on the prevalence of CRF of specific cancer types including understudied cancers such as thyroid cancer and multiple myeloma, and with comparison to a normative population [25][26][27]. The PROFILES registry is also a very suitable resource to identify patterns of fatigue in a large heterogeneous group of cancer survivors as all participants completed a standard fatigue questionnaire.…”

Section: Introductionmentioning

confidence: 99%

Variation in fatigue among 6011 (long-term) cancer survivors and a normative population: a study from the population-based PROFILES registry

Husson

Mols

Poll-Franse

et al. 2015

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Fatigue levels are substantial in (long-term) cancer survivors and vary depending on cancer type, time since diagnosis, age, gender, treatment with chemotherapy, number of comorbid conditions, educational level, and partnership. Since significantly more cancer survivors feel fatigued in comparison with the normative population, appropriate information, assessment, and interventions for fatigue are needed during or after oncologic treatment. Furthermore, focus on better control or management of comorbid conditions of cancer survivors is recommended.

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“…45,46 A strength of our study is the large sample size, which leads to representative results. Moreover, we were able to compare our findings with those of a large reference population.…”

Section: Discussionmentioning

confidence: 99%

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Benzing

Krenzien²,

Krezdorn³

et al. 2017

Exp Clin Transplant

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Objectives: To date, fatigue is still poorly understood in recipients of orthotopic liver transplant and simultaneous/sequential liver and kidney transplant procedures. The present study examined the appearance of fatigue in patients who received orthotopic liver and sequential liver and kidney transplant procedures compared with the general population and the influence of various clinical and socioeconomic factors on fatigue levels. Materials and Methods: The Multidimensional Fatigue Inventory survey was sent to all patients with a history of orthotopic liver and simultaneous/sequential liver and kidney transplant. The results were compared to data from a reference population. Results: Our survey included 276 eligible patients: 256 recipients (92.7%) of orthotopic liver transplant and 20 recipients (7.3%) of simultaneous/sequential liver and kidney transplant. Significantly lower fatigue scores were found in the general population compared with both transplant groups (P < .001). There were also no significant differences between the transplant groups. Among the clinical and socioeconomic factors, history of hepatocellular carcinoma, chronic kidney disease, age, family status, and education had a significant impact on fatigue levels. Conclusions: This is the first study to compare fatigue in recipients of orthotopic liver and simultaneous/-sequential liver and kidney transplant. We found that fatigue is an important but still poorly understood outcome after transplant.

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A high level of fatigue among long-term survivors of non-Hodgkin's lymphoma: results from the longitudinal population-based PROFILES registry in the south of the Netherlands

Cited by 78 publications

References 42 publications

Actual prognosis during follow-up of survivors of B-cell non-Hodgkin lymphoma in the Netherlands

Actual prognosis during follow-up of survivors of B-cell non-Hodgkin lymphoma in the Netherlands

Variation in fatigue among 6011 (long-term) cancer survivors and a normative population: a study from the population-based PROFILES registry

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