Actual prognosis during follow-up of survivors of B-cell non-Hodgkin lymphoma in the Netherlands

Abstract

© F e r r a t a S t o r t i F o u n d a t i o nstage, 16 were obtained routinely from the medical records about 9 months after diagnosis.In addition to passive follow-up via the hospitals, date of death was also retrieved from the Municipal Personal Records Database. Follow-up of vital status was complete until January, 1 st , 2010. For the present study, all patients with mature B-cell NHL newly diagnosed in the period [1989][1990][1991][1992][1993][1994][1995][1996][1997][1998][1999][2000][2001][2002][2003][2004][2005][2006][2007][2008] in the Netherlands were included (n=54,015). Patients with plasma cell neoplasms were excluded. NHL entities were defined according to the World Health Organization classification, 4 th edition. 18 The exact codes used for each entity are described in a previous publication.2 Sufficient patients were available to report the entity-specific conditional relative survival for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL), marginal zone lymphoma (MZL), lymphoplasmacytic lymphoma (LPL), follicular lymphoma (FL), mantle cell lymphoma (MCL), and diffuse large B-cell lymphoma (DLBCL).We also used two major diagnostic subgroups, based on a combination of entities of more or less similar clinical behavior and comparable response to therapies: indolent and aggressive B-cell neoplasms. The entities included in each subgroup are shown in Table 1. Unspecified cases were excluded from these analyses.Patients younger than 15 years and older than 89 years were excluded from the analysis, as were cases diagnosed at autopsy. Patients were divided into four age groups (15-44, 45-59, 60-74, and 75-89 years old). Patients aged 15-29 and 30-44 years were merged, because of the small numbers. Statistical analysesRelative survival is an approximation of disease-specific survival. It is calculated as the absolute survival among cancer patients divided by the expected survival of a comparable group from the general population (same period, age, and gender). Expected survival was calculated from population life tables from the Netherlands, according to the Ederer II method. 19 Period analysis 20,21 was used to provide up-to-date survival estimates; all observations included in the analysis are left-truncated at the beginning of the period of interest, in addition to being right-censored at its end. Furthermore, to enable the estimation of even more up-to-date survival, hybrid analysis was used. 22Five-year relative survival rates were computed for every additional year of survival up to 15 years after diagnosis, conditional on being alive at the beginning of that year (conditional 5-year relative survival, CRS), unadjusted for other variables. Conditional survival was computed according to disease entity, grade, gender, 15-year age group, and stage of disease. For the analysis according to period of diagnosis (1995-2000 versus 2003-2008) conditional 3-year relative survival rates were computed, since follow-up time for patients diagnosed in 2003-2008 was limited. When the CRS pe...

Updating survival estimates in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) based on treatment-free interval length

“…Prior studies of conditional RS patterns in lymphoma patients have noted that in patients with indolent lymphomas such as CLL/SLL, RS5 is more or less unchanged after stratifying on time-since-diagnosis [22]. In contrast, the current study demonstrated that duration of treatment-free survival since diagnosis was predictive of modest but steady improvements in RS5.…”

Conditional relative survival among patients with follicular lymphoma: a population-based study in the Netherlands

“…The present study thus extends on these series by predicting survival for patients diagnosed during 2015–2019. Five-year RS estimated at diagnosis was higher in our study (85; 95% CI, 84–87%), as compared to the earlier series in the Netherlands (72; 95% CI, 71–73%) 3 and the U.S. study (82; 95% CI, 81–83%) 4 . Akin to previous studies in FL, we observed a slight increase in CRS during follow-up that was less pronounced as compared to other types of lymphomas 3 , 4 , 9 , 10 .…”

“…Therefore, survival estimates for patients who have survived from a specified time since diagnosis—especially when corrected for the life expectancy in the general population—add relevant information related to changing survival expectations over time (i.e., conditional relative survival; CRS). At present, published data on CRS in FL are sparse and reasonably outdated 3 , 4 . For this reason, in this nationwide, population-based study, we predicted up-to-date estimates of 5-year relative survival (RS) at diagnosis, and for each additional year survived up to 10 years post-diagnosis among contemporary diagnosed FL patients in the Netherlands using techniques that are conceptually similar to those that estimate the life expectancy at birth.…”

“…To our knowledge, only two population-based studies assessed CRS in FL. One study included patients diagnosed in the Netherlands between 1989–2008 with survival follow-up through 2009 3 . The other study included patients diagnosed in the U.S. between 2000–2012 with survival follow-up through 2012 4 .…”

Optimistic, realistic, and pessimistic illness perceptions; quality of life; and survival among 2457 cancer survivors: the population‐based PROFILES registry

“…Conditional relative survival data from the NCR has been described previously for colorectal 26 and prostate 27 cancer as well as for non-Hodgkin lymphoma. 28 For survivors of endometrial and ovarian cancer in the current study sample who were included within 1 year after diagnosis, the 5-year survival at the time of diagnosis by cancer stage was determined (www. cijfersoverkanker.nl).…”