Variation in fatigue among 6011 (long-term) cancer survivors and a normative population: a study from the population-based PROFILES registry

Husson, Olga; Mols, Floortje; Poll-Franse, Lonneke van de; Vries, Jolanda De; Schep, Goof; Thong, Melissa S. Y.

doi:10.1007/s00520-014-2577-5

Cited by 57 publications

(55 citation statements)

References 41 publications

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“…No domínio físico, os resultados mostraram que, apesar da QV geral dos pacientes com CDT poder ser igual ou até melhor do que a da população geral, o impacto físico da doença ainda é apontado como relevante e se reflete na dimuição dos escores referentes a esse domínio (12) . Os sintomas decorrentes da doença e sua terapêutica afetam o dia-a-dia dos pacientes e não aparecem de forma isolada, pois geralmente são acompanhados de sinais físicos resultantes do tratamento (14)(15) .…”

Section: Discussionunclassified

“…Os pacientes com CDT tratados há mais tempo (≥ 5 anos desde o diagnóstico) sentemse menos cansados quando comparados àqueles tratados há menos de 5 anos (12) . Os efeitos resultantes do tratamento podem ser minimizados com intervenções como um programa específico de exercícios/ prática de atividade física e otimização do tratamento com o objetivo de reduzir a fadiga (17) , que é uma queixa frequente desses indivíduos.…”

Section: Discussionunclassified

“…Uma revisão integrativa (14) , que objetivou analisar a associação entre CDT e QV, identificou resultados contraditórios. Alguns estudos mostraram que a QV apresenta-se diminuída nos sobreviventes do CDT em comparação com a população saudável ou outros grupos de referência, enquanto outros encontraram resultado oposto, assim com o presente estudo (12,30) . Desse modo, mais pesquisas são necessárias para avaliar a QV atual do CDT frente aos avanços em seu diagnóstico e tratamento e para determinar com maior precisão os fatores não relacionados à saúde que a influenciam, uma vez que os pacientes com CDT percebem sua doença de forma muito mais subjetiva e emocional do que objetiva.…”

Section: Discussionunclassified

“…Essas intervenções frequentemente têm consequências físicas e psicológicas indesejáveis para os indivíduos (8,10) , que nem sempre são passíveis de controle (8) e podem gerar impacto negativo em sua QV (2) . Com o passar dos anos, porém, sugere-se que a QV desses pacientes tende a voltar à normalidade (11)(12) .…”

Section: Introductionunclassified

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Avaliação Da Qualidade De Vida De Indivíduos Com Carcinoma Bem Diferenciado De Tireoide Pelo Whoqol-100

Furino

2017

Cogitare Enferm.

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RESUMO: Este estudo objetivou avaliar a qualidade de vida de pacientes em acompanhamento clínico por carcinoma bem diferenciado de tireoide, por meio do questionário WHOQOL-100. Trata-se de estudo quantitativo realizado entre março de 2015 e março de 2017 em São Carlos, SP, Brasil, descritivo e transversal, que avaliou 280 indivíduos, sendo 70 com carcinoma de tireoide e 210 controles, divididos em ≤45 e >45 anos. Os resultados mostraram que o grupo carcinoma de tireoide ≤ 45 anos apresentou prejuízo nos domínios físico (p=0,0032) e nível de independência (p<0,0001), e melhora no domínio meio ambiente (0,0138 RESUMEN: Este estudio objetivó evaluar la cualidad de vida de pacientes en seguimiento clínico por carcinoma bien diferenciado de tiroides, mediante el cuestionario WHOQOL-100. Se trata de estudio cuantitativo desarrollado entre marzo del 2015 y marzo del 2017 en São Carlos, SP, Brasil, descriptivo y trasversal, que evaluó 280 individuos, siendo 70 con carcinoma de tiroides y 210 controles, divididos en ≤45 y >45 años. Los resultados mostraron que el grupo carcinoma de tiroides ≤ 45 años presentó perjuicio en los dominios físico (p=0,0032) y nivel de independencia (p<0,0001), y mejora en el dominio medio ambiente (0,0138). El grupo con carcinoma de tiroides > 45 años presentó mejora en el dominio medio ambiente (0,0002) y calidad de vida global (p=0,00146) con relación a los controles. Eses hallazgos, frutos de un análisis amplio de la calidad de vida de pacientes con carcinoma diferenciado de tiroides, pueden contribuir a la comprensión de las repercusiones de la enfermedad y su tratamiento.

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Section: Discussionunclassified

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Avaliação Da Qualidade De Vida De Indivíduos Com Carcinoma Bem Diferenciado De Tireoide Pelo Whoqol-100

Furino

2017

Cogitare Enferm.

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“…In particular, depression and fatigue are prominent issues (Irwin, Olmstead, Ganz, & Haque, 2013;Prue, Rankin, Allen, Gracey, & Cramp, 2006). Approximately one in five survivors shows symptoms of depression within the first two years following diagnosis (Mitchell, Ferguson, Gill, Paul, & Symonds, 2013) and 30-40% experience fatigue within five years after diagnosis (Husson et al, 2015;Jones et al, 2016). Current guidelines suggest that the patient is mainly held responsible for managing their health and well-being and health care professionals should encourage and support them in self-management (Comprehensive Cancer Centre the Netherlands, 2011; Davies & Batehup, 2011;Fenlon & Foster, 2009).…”

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Working mechanisms of a web-based self-management intervention for cancer survivors: a randomised controlled trial

Willems

Lechner

Verboon

et al. 2017

Psychology & Health

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Objective: The aim of this study was to investigate whether problem-solving skills and perceived personal control over cancer recovery mediated the intervention effects on depression and fatigue of a web-based computertailored intervention for cancer survivors -the Kanker Nazorg Wijzer (Cancer Aftercare Guide). Design: Patients were recruited through 21 Dutch hospitals (November 2013-June 2014. The mediation model was tested in a randomised controlled trial with an intervention group (n = 231) and a waiting list control group (n = 231). Main outcome measures: Hypothesised mediators problem-solving skills (SPSI-R) and personal control (IPQ-R) were measured at baseline and 3 months from baseline. Outcomes depression (HADS) and fatigue (CIS) were measured at baseline and 6 months from baseline. Results: The intervention effects in decreasing depression and fatigue were mediated by personal control. Problem-solving skills did not mediate the intervention effects on depression and fatigue. Conclusion: While personal control in the control group decreased in the first three months after baseline, levels of personal control within the intervention group were maintained. This effect partially explained the intervention effects on depression and fatigue. The results provide evidence for the relevance of addressing personal control in web-based interventions in order to improve psychosocial well-being in early cancer survivors.

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The association of cancer‐related fatigue with all‐cause mortality of colorectal and endometrial cancer survivors: Results from the population‐based PROFILES registry

et al. 2019

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Purpose Cancer‐related fatigue (CRF) is one of the most prevalent symptoms experienced by cancer survivors. However, researchers are only beginning to elucidate the risk factors, underlying mechanism(s), and its association with other outcomes. Research on the association between CRF and mortality is limited. Methods The study sample comprised 2059 short‐term (<5 years postdiagnosis) cancer survivors from four PROFILES registry studies. Survivors diagnosed with stage I‐III colorectal cancer (CRC) or stage I‐III endometrial cancer (EC), with no evidence of disease, were identified and followed‐up by the Netherlands Cancer Registry. Fatigue was assessed with the Fatigue Assessment Scale. Cox proportional hazards models adjusted for demographic, clinical, and lifestyle characteristics were performed to assess the association of CRF with all‐cause mortality. Date of censoring was February 1, 2017. Results Prevalence of CRF varied between 35.8% (male CRC) and 43.6% (female CRC). After a median follow‐up period of 9.0 years, a total of 408 survivors (20%) had died. CRF was associated with increased all‐cause mortality in male CRC survivors (HRadj = 1.75, 95% CI [1.31‐2.33]). This association remained statistically significant after excluding survivors experiencing anhedonia. For female CRC (HRadj = 1.32, 95% CI [0.90‐1.97]) and EC (HRadj = 1.27, 95% CI [0.84‐1.90]) survivors, there was no significant association with all‐cause mortality for the fatigued group in multivariable analyses. Conclusion Our study found that CRF is significantly associated with all‐cause mortality in male CRC survivors, irrespective of potential confounders. This result suggests that clinicians should increase their attention towards the recognition and treatment of CRF.

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Variation in fatigue among 6011 (long-term) cancer survivors and a normative population: a study from the population-based PROFILES registry

Cited by 57 publications

References 41 publications

Avaliação Da Qualidade De Vida De Indivíduos Com Carcinoma Bem Diferenciado De Tireoide Pelo Whoqol-100

Avaliação Da Qualidade De Vida De Indivíduos Com Carcinoma Bem Diferenciado De Tireoide Pelo Whoqol-100

Working mechanisms of a web-based self-management intervention for cancer survivors: a randomised controlled trial

The association of cancer‐related fatigue with all‐cause mortality of colorectal and endometrial cancer survivors: Results from the population‐based PROFILES registry

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