A high level of circulating HOTAIR is associated with progression and poor prognosis of cervical cancer

Li, Jing; Wang, Yuan; Yu, Jinjin; Dong, Ruofan; Qiu, Haifeng

doi:10.1007/s13277-014-2765-4

Cited by 71 publications

(68 citation statements)

References 30 publications

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“…In addition, overexpression of HOTAIR could predict tumor recurrence and short overall survival [24]. As a continuation of our work, we investigated the biological functions of HOTAIR on cervical cancer in the present study.…”

Section: Discussionmentioning

confidence: 81%

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HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer

Wang

Dong

et al. 2014

Tumor Biol.

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We previously reported the frequent overexpression of HOX Antisense Intergenic RNA (HOTAIR) in human cervical cancer, which was significantly correlated with tumor progression and poor prognosis. In the present study, we investigated the detailed biological functions of HOTAIR in cervical cancer. In vitro, upregulation of HOTAIR inhibited apoptosis and promoted cellular proliferation, cell cycle progression, migration, and invasion; on the contrast, downregulation of HOTAIR induced more apoptosis, suppressed cellular proliferation, cell cycle, migration, and invasion. Moreover, a high level of HOTAIR was notably associated with radio-resistance and downregulation of p21 in the primary cultured cervical cancer cells. Further, we demonstrated that elevated HOTAIR could induce radio-resistance via inhibiting p21 in HeLa cells, while knockdown of HOTAIR upregulated p21 and consequentially increased the radio-sensitivity of C33A cells. Consistently, stable knockdown of HOTAIR significantly suppressed tumor growth and sensitized cervical cancer to radiotherapy in vivo. In conclusion, HOTAIR served as an onco-lncRNA in cervical cancer which could enhance various aggressive biological behaviors. Moreover, we proved that HOTAIR execute its functions mainly through inhibiting the p21 expression. These results proposed that targeting HOTAIR might be a potent therapeutic strategy in cervical cancer, especially for those patients who accepted radiotherapy.

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Section: Discussionmentioning

confidence: 81%

“…Moreover, the recurrence-free survival and overall survival for patients with higher circulating HOTAIR were much worse [24]. Herein, we further explored the roles of HOTAIR in cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer

Wang

Dong

et al. 2014

Tumor Biol.

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“…Elevated HOTAIR was associated with advanced tumor stage, lymphatic node metastasis, recurrence, and short OS. Thus, circulating HOTAIR may be used as a potent prognostic marker in patients with CaCx [94][95][96]. Loss-of-function experiments indicated that overexpression of HOTAIR promoted, whereas silencing of HOTAIR inhibited growth, invasion, and cell viability of CaCx cells in vitro and in vivo.…”

Section: Hotair In Cervical Cancermentioning

confidence: 99%

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

Tang

Hann

2018

Cell Physiol Biochem

204

127

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Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined. HOX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability. In this review, we briefly introduce the concept, identification, and biological functions of HOTAIR. We then describe the involvement of HOTAIR that has been associated with tumorigenesis, growth, invasion, cancer stem cell differentiation, metastasis, and drug resistance in cancer. We also discuss emerging insights into the role of HOTAIR as potential biomarkers and therapeutic targets for novel treatment paradigms in cancer.

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“…The expression of some lncRNAs has been reported to suffer important alterations in cervical cancer and has been associated with cancer progression and aggressiveness among the most notably are as follows: H19, HOTAIR, MALAT1, GAS5, MEG3, CCAT2 12, 13, 14, 15, 16, 17.…”

Section: Introductionmentioning

confidence: 99%

LINC01101 and LINC00277 expression levels as novel factors in HPV‐induced cervical neoplasia

Iancu

Anton

Botezatu

et al. 2017

J Cellular Molecular Medi

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Recently long non‐coding RNAs were identified as new factors involved in gene expression regulation. To gain insight into expression pattern of these factors related to E7 HPV18 oncogene, this study uses HeLa cell culture transfected with E7‐siRNA. Gene expression profile was investigated using microarray analysis. After analysing the microarray results, we identified 15,387 RNA species differentially expressed in E7‐siRNA‐transfected cells compared with controls (fold change >2). The expression profiles of lncRNA species highlighted 731 lncRNAs and 203 lincRNAs. We selected two lincRNAs (LINC01101 and LINC00277) and we evaluated the expression profile in HPV‐induced neoplasia. Both lincRNAs investigated display a significantly reduced pattern of expression in cervical lesions and cancer, associated with clinical parameters. A connection between HPV presence and lincRNAs was noted. hrHPV‐positive samples exhibit significantly reduced LINC01101 and LINC00277 expression level (P < 0.05). These results provide new insights into involvement of lncRNA in HPV‐induced cervical cancer, enriching our understanding of their potential role in this pathology.

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A high level of circulating HOTAIR is associated with progression and poor prognosis of cervical cancer

Cited by 71 publications

References 30 publications

HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer

HOTAIR enhanced aggressive biological behaviors and induced radio-resistance via inhibiting p21 in cervical cancer

HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

LINC01101 and LINC00277 expression levels as novel factors in HPV‐induced cervical neoplasia

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