LINC01101 and LINC00277 expression levels as novel factors in HPV‐induced cervical neoplasia

Iancu, Iulia Virginia; Anton, Gabriela; Botezatu, Anca; Huică, Irina; Năstase, Anca; Socolov, Demetra; Stănescu, Anca Daniela; Dima, Simona; Bacalbaşa, Nicolae; Pleşa, Adriana

doi:10.1111/jcmm.13288

Cited by 28 publications

(27 citation statements)

References 25 publications

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“…LncRNA is a class of transcript with more than 200 nucleotides in length, but do not encode proteins . Aberrant expressions of lncRNAs have been revealed in various pathological status, particular in cancers . Furthermore, lncRNAs also play important roles in various pathophysiological processes, including cancers .…”

Section: Introductionmentioning

confidence: 99%

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A positive feedback loop between ZNF205‐AS1 and EGR4 promotes non‐small cell lung cancer growth

Lin

Yang

et al. 2018

J Cellular Molecular Medi

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Accumulating evidences revealed that long noncoding RNAs (lncRNAs) are frequently implicated in non‐small cell lung cancer (NSCLC). Herein, we reported the identification of a novel NSCLC‐associated functional lncRNA ZNF205 antisense RNA 1 (ZNF205‐AS1). ZNF205‐AS1 was increased in NSCLC tissues and cell lines, and associated with poor prognosis of NSCLC patients. Bioinformatics prediction, combined with experimental verification revealed that early growth response 4 (EGR4) directly bound to ZNF205‐AS1 promoter, increased the promoter activity of ZNF205‐AS1, and activated ZNF205‐AS1 transcription. Intriguingly, ZNF205‐AS1 transcript directly interacted with EGR4 mRNA, increased EGR4 mRNA stability, and up‐regulated EGR4 expression via RNA‐RNA interaction. Thus, ZNF205‐AS1 and EGR4 formed a positive feedback loop. Through regulating EGR4, ZNF205‐AS1 activated its own promoter activity. EGR4 was also increased in NSCLC and the expression of ZNF205‐AS1 was significantly positively correlated with EGR4 in NSCLC tissues. Gain‐of‐function and loss‐of‐function assays demonstrated that both ZNF205‐AS1 and EGR4 promoted NSCLC cell growth in vitro and NSCLC tumour growth in vivo. Concurrently depleting ZNF205‐AS1 and EGR4 more significantly repressed NSCLC tumour growth in vivo. Collectively, our study demonstrated that the positive feedback loop between ZNF205‐AS1 and EGR4 promotes NSCLC growth, and implied that targeting this feedback loop may be promising therapeutic strategy for NSCLC.

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Section: Introductionmentioning

confidence: 99%

“…[7][8][9] Aberrant expressions of lncRNAs have been revealed in various pathological status, particular in cancers. [10][11][12][13] Furthermore, lncRNAs also play important roles in various pathophysiological processes, including cancers. [14][15][16][17][18] In NSCLC, several lncRNAs are reported to participate in tumourigenesis and/or development of NSCLC.…”

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confidence: 99%

A positive feedback loop between ZNF205‐AS1 and EGR4 promotes non‐small cell lung cancer growth

Lin

Yang

et al. 2018

J Cellular Molecular Medi

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“…Increasing studies revealed that lncRNAs play an effect on several cellular functions such as cell growth, development, migration, differentiation, metabolism, and many other cell biological processes (Gao, Lv, Li, Han, & Zhang, 2017;Iancu et al, 2017;G. Wang, Pan, Zhang, Wei, & Wang, suppressor gene in several tumors (L. H. Liu, Yue, et al, 2016;Xu et al, 2018;Yang et al, 2017;C.…”

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confidence: 99%

Retracted: LncRNA MT1JP functions as a tumor suppressor via regulating miR‐214‐3p expression in bladder cancer

Wang

Zhu

et al. 2019

Journal Cellular Physiology

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Growing evidence suggested that the long noncoding RNAs (lncRNAs) regulate several pathophysiological processes in tumorigenesis and may be new biomarkers for tumor therapy. In this study, we studied the expression and role of lncRNA MT1JP in the development of bladder cancer. We demonstrated that the expression of MT1JP was downregulated in bladder tumor samples and cell lines. Ectopic expression of MT1JP suppressed cell proliferation, cycle, and invasion in bladder cancer. In addition, our result suggested that miR‐214‐3p overexpression decreased the luciferase activity of wild‐type MT1JP but not mutated‐type MT1JP and elevated expression of MT1JP decreased miR‐214‐3p expression in the bladder cancer cell. Furthermore, we indicated that the expression of miR‐214‐3p was upregulated in bladder tumor samples and cell lines. Ectopic expression of miR‐214‐3p promoted cell proliferation, cycle, and invasion in bladder cancer. MT1JP suppressed cell proliferation, cycle, and invasion via negative modulation of miR‐214‐3p in bladder cancer. These data suggested that lncRNA MT1JP acts a tumor suppressor gene in bladder cancer progression, considering MT1JP as a new therapeutic target in bladder cancer.

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“…Of these, the majority were noncoding RNAs (66%) followed by microRNAs (16%), antisense RNAs (10%), pseudogenes (5%), small nucleolar RNAs (3%), and small nuclear RNAs (<1%). (B) A table of selected characterized noncoding RNA genes bound by TRP47 showing that many are involved cell proliferation or apoptosis and some are also bound by another ehrlichial TRP: NR_027181.1 [ 23 ], NR_029833.1 [ 24 ], NR_029608.1 [ 25 ], NR_126415.1 [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response

et al. 2018

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Ehrlichia chaffeensis is an obligately intracellular bacterium that establishes infection in mononuclear phagocytes through largely undefined reprogramming strategies including modulation of host gene transcription. In this study, we demonstrate that the E. chaffeensis effector TRP47 enters the host cell nucleus and binds regulatory regions of host genes relevant to infection. TRP47 was observed in the nucleus of E. chaffeensis-infected host cells, and nuclear localization was dependent on a variant MYND-binding domain. An electrophoretic mobility shift assay (EMSA) demonstrated that TRP47 directly binds host DNA via its tandem repeat domain. Utilizing chromatin immunoprecipitation followed by high-throughput DNA sequencing (ChIP-seq) with E. chaffeensis-infected cells, TRP47 was found to bind at multiple sites in the human genome (n = 2,051 at p < 10−30). Ontology analysis identified genes involved in functions such as immune response, cytoskeletal organization, and signal transduction. TRP47-bound genes included RNA-coding genes, many of these linked to cell proliferation or apoptosis. Comparison of TRP47 binding sites with those of previously-identified E. chaffeensis nucleomodulins identified multiple genes and gene functional categories in common including intracellular transport, cell signaling, and transcriptional regulation. Further, motif analysis followed by EMSA with synthetic oligonucleotides containing discovered motifs revealed a conserved TRP47 DNA-binding motif. This study reveals that TRP47 is a nucleomodulin that enters the nucleus via a MYND-binding domain and appears to play a role in host cell reprogramming by regulation of transcription.

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LINC01101 and LINC00277 expression levels as novel factors in HPV‐induced cervical neoplasia

Cited by 28 publications

References 25 publications

A positive feedback loop between ZNF205‐AS1 and EGR4 promotes non‐small cell lung cancer growth

A positive feedback loop between ZNF205‐AS1 and EGR4 promotes non‐small cell lung cancer growth

Retracted: LncRNA MT1JP functions as a tumor suppressor via regulating miR‐214‐3p expression in bladder cancer

Ehrlichia chaffeensis TRP47 enters the nucleus via a MYND-binding domain-dependent mechanism and predominantly binds enhancers of host genes associated with signal transduction, cytoskeletal organization, and immune response

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