A Handheld Imaging Probe for Acoustic Angiography With an Ultrawideband Capacitive Micromachined Ultrasonic Transducer (CMUT) Array

Sanders, Jean L.; Biliroglu, Ali Onder; Newsome, Isabel G.; Adelegan, Oluwafemi J.; Yamaner, F. Yalcın; Dayton, Paul A.; Oralkan, Ömer

doi:10.1109/tuffc.2022.3172566

Cited by 8 publications

(5 citation statements)

References 57 publications

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“…The footprint of the array was 3.0 mm × 24.9 mm, as shown in Fig. 1(a) [ 21 – 23 ]. The lateral and elevational dimensions of the elements are 99 µm and 2988 µm, respectively.…”

Section: Methodsmentioning

confidence: 99%

Photoacoustic imaging of visually evoked cortical and subcortical hemodynamic activity in mouse brain: feasibility study with piezoelectric and capacitive micromachined ultrasonic transducer (CMUT) arrays

Chang,

Belekov,

Wang

et al. 2023

Biomed. Opt. Express

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This study investigates the feasibility of capturing visually evoked hemodynamic responses in the mouse brain using photoacoustic tomography (PAT) and ultrasound (US) dual-modality imaging. A commercial piezoelectric transducer array and a capacitive micromachined ultrasonic transducer (CMUT) array were compared using a programmable PAT-US imaging system. The system resolution was measured by imaging phantoms. We also tested the ability of the system to capture visually evoked hemodynamic responses in the superior colliculus as well as the primary visual cortex in wild-type mice. Results show that the piezoelectric transducer array and the CMUT array exhibit comparable imaging performance, and both arrays can capture visually evoked hemodynamic responses in subcortical as well as cortical regions of the mouse brain.

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“…The footprint of the array was 3.0 mm × 24.9 mm, as shown in Fig. 1(a) [ 21 – 23 ]. The lateral and elevational dimensions of the elements are 99 µm and 2988 µm, respectively.…”

Section: Methodsmentioning

confidence: 99%

Photoacoustic imaging of visually evoked cortical and subcortical hemodynamic activity in mouse brain: feasibility study with piezoelectric and capacitive micromachined ultrasonic transducer (CMUT) arrays

Chang,

Belekov,

Wang

et al. 2023

Biomed. Opt. Express

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“…Multi-frequency operation is required in acoustic angiography applications, where a focused low-frequency ultrasound beam is used at the transmitter side to excite the contrast agents, known as microbubbles, injected in the bloodstream, while sensing of high frequencies (third and higher harmonics) is targeted at the receiver side for eliminating unwanted reflections in the surrounding tissue and instead imaging only the microbubbles [77]. The different response of tissue (linear) and microbubbles (highly non-linear) to acoustic excitations allows generating images with high contrast-to-tissue ratio and resolution [78].…”

Section: Pmut and Cmut For Biomedical Applicationsmentioning

confidence: 99%

“…Tuning of the bias voltage and exploiting the CMUT collapse mode operation [78]- [80], as explained previously, are viable solutions for multi-frequency operation. Another CMUT implementation employs a reduced bottom electrode and added central mass on a thin plate [77] in order to achieve broadband response: the reduced bottom electrode increases the bandwidth by focusing the electrostatic force in the central area of the membrane, where it is most effective, and by decreasing the in-cell parasitic capacitance, while the added mass on the CMUT plate allows decoupling the spring constant and the plate mass, thus breaking the trade-off between a higher pressure narrower bandwidth device and lower pressure wider bandwidth device, and tuning the higher order vibrational mode frequencies.…”

Section: Pmut and Cmut For Biomedical Applicationsmentioning

confidence: 99%

PMUT and CMUT Devices for Biomedical Applications: A Review

Moisello,

Novaresi,

Sarkar

et al. 2024

IEEE Access

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Piezoelectric Micromachined Ultrasonic Transducers (PMUT) and Capacitive Micromachined Ultrasonic Transducers (CMUT) have seen great developments in recent years, both in terms of performance and scope of applications within the biomedical ultrasound domain. This paper presents a review of the state-of-the-art of PMUT and CMUT technologies, focusing on their principle of operation, microfabrication techniques and use in different biomedical imaging and therapeutic applications. The advantages and drawbacks of PMUT and CMUT technologies in comparison with conventional bulk transducers are highlighted, the trade-offs among PMUTs and CMUTs are discussed, and their relevance in the current landscape of medical diagnostics and therapeutic uses is outlined, thus providing a clear overview of these promising technologies for the present and the next generation biomedical ultrasound applications.

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“…These higher-order harmonic signals are unique to MBs (i.e., are not produced by tissue), so a broadband transducer capable of sensing these high-frequency harmonics can produce very high-quality images of small vasculature. This approach is also referred to as acoustic angiography [41] , [42] .…”

Section: Recent Cmut Research Progressmentioning

confidence: 99%

“…For these purposes, cMUT devices have been created and used for dual-frequency or multiband operation by various means [42] , [44] , [45] . One approach involves fabrication of two different cMUT cell sizes (membrane diameters) interlaced within the area of an array element (see Fig.…”

Section: Recent Cmut Research Progressmentioning

confidence: 99%