A genetic approach to study the relationship between maternal Vitamin D status and newborn anthropometry measurements: the Vitamin D pregnant mother (VDPM) cohort study

Abstract

Purpose Adverse effects of maternal vitamin D deficiency have been linked to adverse pregnancy outcomes. We investigated the relationship between maternal vitamin D status and newborn anthropometry measurements using a genetic approach and examined the interaction between genetic variations in involved in vitamin D synthesis and metabolism and maternal vitamin D concentrations on newborn anthropometry. Methods The study was conducted in 183 pregnant Indonesian Minangkabau women. Genetic risk scores (GRSs) were created using six vitamin D–related single nucleotide polymorphisms and their association with 25-hydroxyvitamin D [25(OH)D] levels and newborn anthropometry (183 infants) were investigated. Results There was no significant association between maternal 25(OH)D concentrations and newborn anthropometry measurements (P > 0.05, for all comparisons). After correction for multiple testing using Bonferroni correction, GRS was significantly associated with 25(OH)D in the third trimester (P = 0.004). There was no association between GRS and newborn anthropometric measurements; however, there was an interaction between GRS and 25(OH)D on head circumference (P = 0.030), where mothers of neonates with head circumference < 35 cm had significantly lower 25(OH)D if they carried ≥4 risk alleles compared to those who carried ≤3 risk alleles. Conclusion Our findings demonstrate the impact of vitamin D-related GRS on 25(OH)D and provides evidence for the effect of vitamin D-related GRS on newborn anthropometry through the influence of serum 25(OH)D levels among Indonesian pregnant women. Even though our study is a prospective cohort, before the implementation of vitamin D supplementation programs in Indonesia to prevent adverse pregnancy outcomes, further large studies are required to confirm our findings.

Interaction between Vitamin D-Related Genetic Risk Score and Carbohydrate Intake on Body Fat Composition: A Study in Southeast Asian Minangkabau Women

“…Indonesia is a country in Southeast Asia consisting of more than seventeen thousand islands that are split by the equator resulting in a tropical climate rich in sunlight with typically even temperatures year-round. Nevertheless, VDD rates are high in Indonesian women ranging between 60% to 95% [ 15 ]. Furthermore, incidence of obesity and T2D are high in Indonesia [ 16 ], with estimates of obesity and central obesity prevalence of 23.1% and 28%, respectively, based on data from Indonesia’s national health survey [ 17 ], and 10.3 million people are living with T2D, which constitutes as a major public health concern [ 18 ].…”

Micronutrients Intake Status Between Risk and Non-Risk Anemia Groups Among University Students in Indonesia

“…Copper is also associated with the iron oxidation for the formation of hemoglobin (24). All these micronutrients as important as macronutrients to maintain women health and prevent the complication during the pregnancy, a life cycle for women childbearing age (2,4,3,9,14,20). Furthermore, the aim of this study was to identify whether micronutrient intake status affect the risk of anemia among University female students in the Alma Ata University, Yogyakarta.…”

Anemia prevalence and its associated risk factors among Minangkabau pregnant women in West Sumatra, Indonesia: findings from VDPM cohort study

“…This was a secondary data analysis from "Vitamin D Pregnant Mother (VDPM) study in West Sumatra". 2,3 The third trimester pregnant women were enrolled from the public health centers in West Sumatra Province from January to March 2018. Structured questionnaires were used to collect the data of demographic, socio-economic, anthropometry, and health history.…”