Purpose Adverse effects of maternal vitamin D deficiency have been linked to adverse pregnancy outcomes. We investigated the relationship between maternal vitamin D status and newborn anthropometry measurements using a genetic approach and examined the interaction between genetic variations in involved in vitamin D synthesis and metabolism and maternal vitamin D concentrations on newborn anthropometry. Methods The study was conducted in 183 pregnant Indonesian Minangkabau women. Genetic risk scores (GRSs) were created using six vitamin D–related single nucleotide polymorphisms and their association with 25-hydroxyvitamin D [25(OH)D] levels and newborn anthropometry (183 infants) were investigated. Results There was no significant association between maternal 25(OH)D concentrations and newborn anthropometry measurements (P > 0.05, for all comparisons). After correction for multiple testing using Bonferroni correction, GRS was significantly associated with 25(OH)D in the third trimester (P = 0.004). There was no association between GRS and newborn anthropometric measurements; however, there was an interaction between GRS and 25(OH)D on head circumference (P = 0.030), where mothers of neonates with head circumference < 35 cm had significantly lower 25(OH)D if they carried ≥4 risk alleles compared to those who carried ≤3 risk alleles. Conclusion Our findings demonstrate the impact of vitamin D-related GRS on 25(OH)D and provides evidence for the effect of vitamin D-related GRS on newborn anthropometry through the influence of serum 25(OH)D levels among Indonesian pregnant women. Even though our study is a prospective cohort, before the implementation of vitamin D supplementation programs in Indonesia to prevent adverse pregnancy outcomes, further large studies are required to confirm our findings.
Perdarahan postpartum menduduki peringkat pertama dalam menyumbangkan angka kematian ibu di dunia, yaitu sebesar 35%. Faktor-faktor yang mempengaruhi kejadian HPP yaitu usia, jumlah paritas, jarak antar kelahiran, ANC, riwayat persalinan dan kehamilan sebelumnya, anemia, dan tingkat pengetahuan ibu. Penelitian ini bertujuan untuk mengetahui gambaran profil pasien hemorrhagic postpartum di RSUP Dr. M. Djamil periode Januari 2016 - September 2017. Penelitian ini merupakan deskriptif retrospektif dengan desain cross-sectional. Sampel berjumlah 39 sampel berupa rekam medis pasien dari bagian rekam medis RSUP Dr. M. Djamil Padang pada bulan Januari 2016 - September 2017 dengan menggunakan teknik simple random sampling dan analisis univariat. Hasil penelitian menunjukkan bahwa HPP terbanyak yang terjadi di RSUP Dr. M. Djamil adalah HPP Primer (79,5%), ibu dengan usia 21-34 tahun (69,2%), ibu dengan paritas lebih dari 2 kali atau multipara (89,4%), ibu dengan tingkat kepatuhan ANC yang tinggi (100%), ibu dengan jarak antara kelahiran <2 tahun (66,7%), ibu yang tidak ada riwayat kehamilan dan persalinan yang buruk (66,7%), ibu dengan kadar Hb <11 gr% (92,4%), ibu dengan tingkat pendidikan tinggi (87,2%), ibu dengan etiologi retensio plasenta (38,5%), dan kematian ditemukan pada ibu dengan HPP primer (2,5%). Dapat disimpulkan bahwa perlunya edukasi kepada wanita terkait pencegahan faktor risiko HPP seperti melakukan ANC rutin untuk mencegah anemia pada ibu hamil dan mengikuti program KB untuk mengatur jarak antara kelahiran.
West Pasaman District and Agam District are filariasis-endemic areas in West Sumatra with prevalence of 12.40 per 100,000 cases and 11.27 per 100,000 cases respectively. This study aimed to determine risk factors associated with the prevalence of filariasis and mapping the vulnerability of the area in West Sumatra. A case control study design was conducted in the West Pasaman District and Agam District. The study used a sample of 74 cases and 74 controls taken by simple random sampling for the case and purposive random sampling for control. Data analysis used univariate, bivariate, multivariate and spatial. The results in Agam District showed that variables associated relation with filariasis (p value < 0.05) were the level of knowledge, plantations, the paddy, the ceiling of the house. The most dominant risk factor was knowledge. Type of vector that was found was Culex. While in West Pasaman District, the variable associated with filariasis (p value < 0.05) was the use of mosquito nets, the habit of dressing, marshes, and ceiling. The most dominant risk factor was the ceiling of the house. Keywords: Filariasis, geographic information system, risk, vulnerabilities AbstrakKabupaten Pasaman Barat dan Kabupaten Agam adalah daerah endemis filariasis di Sumatra Barat dengan prevalensi masing-masing 12,40 per 100.000 kasus dan 11,27 per 100.000 kasus. Penelitian ini bertujuan untuk mengetahui faktor risiko yang terkait dengan prevalensi filariasis dan pemetaan kerentanan daerah di Sumatra Barat. Desain studi kasus kontrol dilakukan di Pasaman Barat dan Agam. Penelitian ini menggunakan sampel dari 74 kasus dan 74 kontrol, diambil secara simple random sampling untuk kasus dan purposive random sampling untuk kontrol. Analisis data menggunakan univariat, bivariat, multivariat dan spasial. Hasil penelitian di Kabupaten Agam menunjukkan bahwa variabel yang berhubungan dengan filariasis (nilai p < 0,05) adalah tingkat pengetahuan, perkebunan, padi, plafon rumah. Faktor risiko yang paling dominan adalah pengetahuan. Jenis vektor yang ditemukan adalah Culex. Sedangkan di Kabupaten Pasaman Barat, variabel hubungan dengan filariasis (nilai p < 0,05) adalah penggunaan kelambu, kebiasaan berpakaian, rawa-rawa, plafon rumah. Faktor risiko yang paling dominan adalah plafon rumah.
Caries is the main problem of oral health. Caries are frequently found in children are milk bottle caries and caries Rampan. Cariogenic food consumption is a Rampant caries etiology. This study was to determine the relationship of type and frequency to consume cariogenic snacks with the case of caries Rampant in children age 5 -6 years.The research method used is analytic observational study design with a cross sectional study, samples were taken purposive methode with total sampling technique and using the chisquare statistical test. Subjects were pre-school age children from 3 unit Pre-school in Padang.There is a significant relationship between the type of consumption of cariogenic snacks with caries Rampant (p=0,005), There is a significant relationship between frequency of consumption of cariogenic snacks with caries Rampant (p=0,000).It is suggested to parents to control and monitor the type and frequency of consumption of cariogenic snacks in children.
<p><em>Breast cancer is known as carsinoma mammae that malignant tumor growing in breast tissue. Patient of breast cancer will being have in the change of body shape, psychology (such as depression and anxiety level), socializing, sexual and daily activities. That is will affected to quality of life of patients (QOL). This study aims to determine the factors that affect the quality of life of breast cancer patients in the city of Padang West Sumatra</em><em>. T</em><em>his research uses analytics design with cross sectional approach. The number of samples are 34 patients with total sampling technique which adjusted to inclusion and exclusion criteria. Data processing use univariat and bivariat method. The result showed that responden characteristic of breast cancer in padang city has average ages around 52,58±10,323 years old with the oldest is 74 years old and the youngest is 33 years old. The average height of respondents</em><em> 153,77±5,346cm</em><em>,</em><em> </em><em>the level of education is SMA and University</em><em> (38,5%)</em><em>,</em><em> </em><em>the respondents’ job of this research are mostly unemployment</em><em> (65,4%), </em><em> the most stadium level is II and III which is 12 people each other</em><em> (46,2%). </em><em>Overall the quality of life of breast cancer sufferer in padang city from 2014-2017 was </em><em>mostly excellent (15.4%), good (46.2%), moderately good (42.3%) and moderate (7.7% ). </em><em>However, the symptoms was complained</em><em> </em><em>by the respondents are fatique</em><em> </em>(38,9%)<em> </em><em>and nausea</em><em> </em>(80,8%). <em>It can be concluded that age, job, education level, bodymass index and stadium are not related to quality of life</em><em> of breast cancer respondents in Padang city of West Sumatra.</em></p><p> </p><p>Kanker payudara disebut juga <em>carcinoma mammae</em> yaitu tumor ganas yang tumbuh pada jaringan payudara. Penderita kanker payudara akan mengalami perubahan fisik, psikologis (seperti tingkat depresi dan kecemasan), fungsi sosial, seksual serta aktifitas sehari-hari. Hal ini akan berpengaruh terhadap kualitas hidup atau <em>quality of life</em> (QOL) penderita. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berpengaruh terhadap kualitas hidup penderita kanker payudara di Kota Padang Sumatera Barat. Penelitian ini menggunakan desain analitik dengan pendekatan <em>cross sectional</em><em>. </em>Sampel berjumlah 34 penderita, dengan teknik pengambilan sampel menggunakan <em>total sampling</em> yang disesuaikan dengan kriteria inklusi dan ekslusi. Pengolahan data menggunakan analisis univariat dan bivariat. Hasil penelitian menunjukkan bahwa karakteristik responden kanker payudara di kota Padang rerata umur responden adalah 52,50±10,332 tahun dengan usia tertua 74 tahun dan termuda 33 tahun. Tinggi badan responden penelitian rerata adalah 153,77±5,346cm. Tingkat pendidikan responden adalah SMA dan Perguruan Tinggi masing-masing 10 orang (38,5%). Pekerjaan responden penelitian ini adalah tidak bekerja 17 orang (65,4%), tingkat stadium terbanyak adalah stadium II dan III yaitu masing-masing 12 orang (46,2%). Kualitas hidup keseluruhan penderita kanker payudara di Kota Padang tahun 2014-2017 sebagian besar masuk dalam skala sangat baik (15,4%), baik (46,2%), agak baik (42,3%) dan sedang (7,7%). Namun gejala yang dikeluhkan responden adalah <em>fatique</em> sering pada 10 orang (38,9%), dan <em>nause</em> selalu pada 21 orang (80,8%). Dapat disimpulkan bahwa umur , pekerjaan, tingkat pendidikan, indeks masa tubuh dan stadium berpengaruh terhadap kualitas hidup responden kanker kanker payudara di Kota Padang Sumatera Barat.</p>
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.