A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos

Krauß, Stefan; Concordet, Jean‐Paul; Ingham, Philip W.

doi:10.1016/0092-8674(93)90628-4

Cited by 1,018 publications

(684 citation statements)

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“…Furthermore, motor neurons are completely absent in Shh knockout mouse embryos (Chiang et al, 1996;Litingtung and Chiang, 2000a). Because zebrafish express multiple hedgehogs in the floor plate and notochord (Krauss et al, 1993;Ekker et al, 1995;Currie and Ingham, 1996), motor neurons are decreased but not lost completely in the zebrafish shh mutant (Chandrasekhar et al, 1998;Schauerte et al, 1998). However, removing multiple hedgehog activities leads to near absence of all motor neurons (Beattie et al, 1997;Bingham et al, 2001).…”

Section: Induction Of Branchiomotor Neuronsmentioning

confidence: 99%

Turning heads: Development of vertebrate branchiomotor neurons

Chandrasekhar

2003

Developmental Dynamics

164

204

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The cranial motor neurons innervate muscles that control eye, jaw, and facial movements of the vertebrate head and parasympathetic neurons that innervate certain glands and organs. These efferent neurons develop at characteristic locations in the brainstem, and their axons exit the neural tube in well-defined trajectories to innervate target tissues. This review is focused on a subset of cranial motor neurons called the branchiomotor neurons, which innervate muscles derived from the branchial (pharyngeal) arches. First, the organization of the branchiomotor pathways in zebrafish, chick, and mouse embryos will be compared, and the underlying axon guidance mechanisms will be addressed. Next, the molecular mechanisms that generate branchiomotor neurons and specify their identities will be discussed. Finally, the caudally directed or tangential migration of facial branchiomotor neurons will be examined. Given the advances in the characterization and analysis of vertebrate genomes, we can expect rapid progress in elucidating the cellular and molecular mechanisms underlying the development of these vital neuronal networks.

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Section: Induction Of Branchiomotor Neuronsmentioning

confidence: 99%

Turning heads: Development of vertebrate branchiomotor neurons

Chandrasekhar

2003

Developmental Dynamics

164

204

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“…Hedgehog was identified in genetic screens in Drosophila in 1980, and the vertebrate hedgehog proteins were discovered in 1993 (Krauss et al, 1993; Nusslein-Volhard and Wieschaus, 1980). Since then, investigations on the role of hedgehog signaling in organ development and diseases progression have rapidly accelerated.…”

Section: Introductionmentioning

confidence: 99%

Sonic hedgehog signaling in kidney fibrosis: a master communicator

Zhou

Tan

Liu

2016

Sci. China Life Sci.

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The hedgehog signaling cascade is an evolutionarily conserved pathway that regulates multiple aspects of embryonic development and plays a decisive role in tissue homeostasis. As the best studied member of three hedgehog ligands, sonic hedgehog (Shh) is known to be associated with kidney development and tissue repair after various insults. Recent studies uncover an intrinsic link between dysregulated Shh signaling and renal fibrogenesis. In various types of chronic kidney disease (CKD), Shh is upregulated specifically in renal tubular epithelium but targets interstitial fibroblasts, thereby mediating a dynamic epithelial-mesenchymal communication (EMC). Tubule-derived Shh acts as a growth factor for interstitial fibroblasts and controls a hierarchy of fibrosis-related genes, which lead to the excessive deposition of extracellular matrix in renal interstitium. In this review, we recapitulate the principle of Shh signaling, its activation and regulation in a variety of kidney diseases. We also discuss the potential mechanisms by which Shh promotes renal fibrosis and assess the efficacy of blocking this signaling in preclinical settings. Continuing these lines of investigations will provide novel opportunities for designing effective therapies to improve CKD prognosis in patients.

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“…In the early 1990s, three homologs of the Hh gene were identified in vertebrates (Echelard et al, 1993;Krauss et al, 1993;Riddle et al, 1993;Chang et al, 1994;Roelink et al, 1994). As an essential developmental signaling pathway, the Hh pathway is critical for maintaining tissue polarity and stem cell population.…”

Section: Introductionmentioning

confidence: 99%