A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection

Lin, Zhiyun; Zhao, Ying; Chu, Paul K.; Wang, Luning; Pan, Haobo; Zheng, Yufeng; Wu, S. L.; Liu, Xuanyong; Cheung, Kenneth M.C.; Wong, Teresa Yuk‐Hwa; Yeung, Kelvin Wai Kwok

doi:10.1016/j.biomaterials.2019.119372

Cited by 86 publications

(68 citation statements)

References 87 publications

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“…Moreover, the acidic environment caused by bacteria infection is unfavourable and reduces osteoblast viability. Many strategies to resist infection such as anti-adhesive surface, [48] combining antibiotics, [49] antimicrobial metal ions [50] or nanoparticles, [51,52] antimicrobial peptides, [53] as well as antibacterial photothermal agent, [54,55] have been developed, which aim to achieve both antibacterial and osteogenic effect in vivo.…”

Section: Materials Considerations For Biocompatibility Mechanical Strength and Osteogenesismentioning

confidence: 99%

“…[7] The nanoparticles and nanoporous film on the surface of bone grafts are beneficial for M2 macrophage polarization, thus promoting bone formation by their anti-inflammatory potential. [114] Moreover, nanosurface is found to support the superior osseointegration [55,[115][116][117] of bone grafts. The osteointegration of Ti-based grafts with nanosurface is contributed by the upregulation of neuronal PAS domain 2 (Npas2) but the underlying mechanism is still unclear.…”

Section: Biomimicking Structures Of Native Bone Tissue For Efficient Osteogenesis and Angiogenesismentioning

confidence: 99%

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Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Xie

Liang

et al. 2021

Adv Healthcare Materials

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The failure to repair critical-sized bone defects often leads to incomplete regeneration or fracture non-union. Tissue-engineered grafts have been recognized as an alternative strategy for bone regeneration due to their potential to repair defects. To design a successful tissue-engineered graft requires the understanding of physicochemical optimization to mimic the composition and structure of native bone, as well as the biological strategies of mimicking the key biological elements during bone regeneration process. This review provides an overview of engineered graft-based strategies focusing on physicochemical properties of materials and graft structure optimization from macroscale to nanoscale to further boost bone regeneration, and it summarizes biological strategies which mainly focus on growth factors following bone regeneration pattern and stem cell-based strategies for more efficient repair. Finally, it discusses the current limitations of existing strategies upon bone repair and highlights a promising strategy for rapid bone regeneration.

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Section: Materials Considerations For Biocompatibility Mechanical Strength and Osteogenesismentioning

confidence: 99%

Section: Biomimicking Structures Of Native Bone Tissue For Efficient Osteogenesis and Angiogenesismentioning

confidence: 99%

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Xie

Liang

et al. 2021

Adv Healthcare Materials

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“…However, the fast degradation in the initial period of implantation is inevitable, because the intrinsic low standard potential of Mg (−2.37 V vs NHE) [ 13 ]. Another choice is surface modification, such as plasma electrolytic oxidation, spray coating, hydrofluoric acid treatment, hydrothermal treatment and plasma ion immersion implantation [ [14] , [15] , [16] , [17] , [18] ]. Among these films, layered double hydroxide (LDH) have been extensively studied for its biodegradation and unique structure, as well as favorable corrosion protection [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg

Cheng

Zhang

et al. 2021

Bioactive Materials

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Layered double hydroxides (LDHs) are widely studied to enhance corrosion resistance and biocompatibility of Mg alloys, which are promising bone implants. However, the influence of LDH coating on the osteointegration of Mg implants lacks of a systematic study. In this work, Mg-Al LDH coating was prepared on pure Mg via hydrothermal treatment. The as-prepared Mg-Al LDH coated Mg exhibited better in vitro and in vivo corrosion resistance than bare Mg and Mg(OH) 2 coated Mg. In vitro culture of mouse osteoblast cell line (MC3T3-E1) suggested that Mg-Al LDH coated Mg was more favorable for its osteogenic differentiation. In vitro culture of HUVECs revealed that cells cultured in the extract of Mg-Al LDH coated Mg showed superior angiogenic behaviors. More importantly, the immune response of Mg-Al LDH coated Mg was studied by in vitro culturing murine-derived macrophage cell line (RAW264.7). The results verified that Mg-Al LDH coated Mg could induce macrophage polarize to M2 phenotype (anti-inflammatory). Furthermore, the secreted factor in the macrophage-conditioned culture medium of Mg-Al LDH group was more suitable for the bone differentiation of rat bone marrow stem cells (rBMSCs) and the angiogenic behavior of human umbilical vein endothelial cells (HUVECs). Finally, the result of femoral implantation suggested that Mg-Al LDH coated Mg exhibited better osteointegration than bare Mg and Mg(OH) 2 coated Mg. With favorable in vitro and in vivo performances, Mg-Al LDH is promising as protective coating on Mg for orthopedic applications.

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“…It is well known that titanium oxide is chemically stable, and the biocompatibility of a titanium oxide coating has been demonstrated [17][18][19]. In a representative literature, Huang et al [20] synthesized titanium oxide film on a cobalt alloy by ion beam-enhanced deposition at below 180 • C, and proved that titanium oxide was an excellent blood contact material because of the semiconductor nature.…”

Section: Introductionmentioning

confidence: 99%

Properties of Titanium Oxide Coating on MgZn Alloy by Magnetron Sputtering for Stent Application

Hou

Yang

et al. 2020

Coatings

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Constructing surface coatings is an effective way to improve the corrosion resistance and biocompatibility of magnesium alloy bioabsorbable implants. In this present work, a titanium oxide coating with a thickness of about 400 nm was successfully prepared on a MgZn alloy surface via a facile magnetron sputtering route. The surface features were characterized using scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and the contact angle method. The corrosion behavior and biocompatibility were evaluated. The results indicated that the amorphous TiO2 coating with a flat and dense morphology was obtained by magnetron-sputtering a titanium oxide target. The corrosion current density decreased from 1050 (bare MgZn alloy) to 49 μA/cm2 (sample with TiO2 coating), suggesting a significant increase in corrosion resistance. In addition, the TiO2 coating showed good biocompatibilities, including significant reduced hemolysis and platelet adhesion, and increased endothelial cell viability and adhesion.

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A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection

Cited by 86 publications

References 87 publications

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Advanced Strategies of Biomimetic Tissue‐Engineered Grafts for Bone Regeneration

Osteogenesis, angiogenesis and immune response of Mg-Al layered double hydroxide coating on pure Mg

Properties of Titanium Oxide Coating on MgZn Alloy by Magnetron Sputtering for Stent Application

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