A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders

Kunugi, Hiroshi; Ishida, S; Kato, Takeshi; Tatsumi, Masahiko; Sakai, Tetsuo; Hattori, Mineko; Hirose, Tetsuya; Nanko, Shinichiro

doi:10.1038/sj.mp.4000558

Cited by 98 publications

(57 citation statements)

References 6 publications

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“…In addition, the MAOA-LPR has been associated with bipolar disorders particularly in females (Ho et al, 2000), and with suicide in depressed males (Du et al, 2002), whereas other studies failed to detect association with suicidal behavior in mood disorders (Kunugi et al, 1999;Kirov et al, 1999;Syagailo et al, 2001;Ono et al, 2002). Although not consistently replicated (Craddock et al, 1995;Nothen et al, 1995), various other MAOA variations were found to influence addictive behavior (Parsian et al, 1995;Vanyukov et al, 1995;Hsu et al, 1996;Gade et al, 1998) and the risk for affective und anxiety disorders (Schulze et al, 2000;Deckert et al, 1999;Furlong et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Cluster B Personality Disorders are Associated with Allelic Variation of Monoamine Oxidase A Activity

Jacob

Müller

Schmidt

et al. 2005

Neuropsychopharmacol

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Genetic variants of the monoamine oxidase A (MAOA) have been associated with aggression-, anxiety-, and addiction-related behavior in several nonclinical and clinical populations. Here, we investigated the influence of allelic variation of MAOA activity on aggressionrelated personality traits and disease risk in patients with personality disorders. Personality disorders were diagnosed with the Structured Clinical Interview of DSM-IV and were allocated to cluster A, B, and C. Personality features were assessed by the revised NEO Personality Inventory and the Tridimensional Personality Questionnaire. The genotype of the MAOA gene-linked polymorphic region (MAOA-LPR) was determined in 566 patients with personality disorders and in 281 healthy controls. MAOA genotype was significantly associated with cluster B personality disorders (w 2 ¼ 7.77, p ¼ 0.005, df ¼ 1) but not with cluster C personality disorders. In total, 26.0% of cluster B patients were hemi-or homozygous for the low-activity variant of the MAOA genotype, compared to 16.4% in the control group. Associations between MAOA variants and personality domains related to impulsivity and aggressiveness were inconsistent. Our findings further support the notion that allelic variation of MAOA activity contributes modestly to the balance of hyper-(impulsiveaggressive) and hyporeactive (anxious-depressive) traits.

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Section: Introductionmentioning

confidence: 99%

Cluster B Personality Disorders are Associated with Allelic Variation of Monoamine Oxidase A Activity

Jacob

Müller

Schmidt

et al. 2005

Neuropsychopharmacol

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“…Concerning suicide the results are not convincing as no association was identified for the MAOA uVNTR variant and only a weak association (P = 0.016) of the Fnu4HI locus with a history of suicide attempts in female bipolar patients, but not in males. 159 Further studies failed to find an association between suicidality and the MAO uVNTR in heroindependent subjects of Italian descent, 160 in Japanese unipolar and bipolar patients 159,161,162 or Japanese suicide victims. 162 Only in the study by Du et al 163 a positive result with the MAOA gene was observed.…”

Section: Monoamine Oxidase Amentioning

confidence: 99%

Genetics of suicide

2006

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The concept that genetic factors contribute to the complex trait of suicidal behaviour has stimulated much work aimed at identifying susceptibility genes. So far molecular genetic studies focused on the serotonergic pathway as the intent to die and the lethality of suicide acts were related to the serotonergic system. Two genes have so far emerged as being involved in the vulnerability for suicidality: first, the intronic polymorphisms (A218C or A779C) of the tryptophan hydroxylase 1 (TPH1) gene, which was suggested as a quantitative risk factor for suicidal behaviour; second, the insertion/deletion polymorphism of the serotonin transporter gene (5-HTTLPR), which does not seem to be involved in general suicidal behaviour, but in violent and repeated suicide attempts. The data have further shown that the MAOA gene, which is consistently associated with impulsive-aggressive personality traits, is not related to suicide but might induce violent methods in subjects with other suicide risk factors. Predominantly negative were the findings with any type of the serotonin receptors and inconsistent with catecholamine-synthesizing and -metabolizing enzymes or with the dopaminergic receptors. This paper reviews the status of current knowledge in this area, points to the weakness of the investigations and presents new approaches beyond the serotonergic system.

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“…2ª-Repetição polimórfica na região promotora do gene codificando a monoaminooxidase A (MAO-A) que Lim et al (1995) relataram estar associada ao transtorno bipolar, no que foram replicados por Preisig et al (2000), embora relatos negativos também existam (Kunugi et al, 1999).…”

Section: Estudos De Associaçãounclassified

Genética dos transtornos afetivos

Lima¹,

Sougey²,

Filho

2004

Rev. psiquiatr. clín.

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Os autores revisam neste artigo o conjunto de evidências genético-epidemiológicas que indicam a presença de fatores genéticos na vulnerabilidade para os transtornos afetivos. Apresentam também os dados obtidos até o momento, através de estratégias de genética molecular na busca de genes de susceptibilidade para o transtorno afetivo bipolar e para a depressão.
In this article the authors review the body of genetic-epidemiological evidences for the role of genes in mood disorders. Current molecular genetic studies searching for susceptibility genes for bipolar affective disorder and depression are also presented

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A functional polymorphism in the promoter region of monoamine oxidase-A gene and mood disorders

Cited by 98 publications

References 6 publications

Cluster B Personality Disorders are Associated with Allelic Variation of Monoamine Oxidase A Activity

Cluster B Personality Disorders are Associated with Allelic Variation of Monoamine Oxidase A Activity

Genetics of suicide

Genética dos transtornos afetivos

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