A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

Liu, He; Wang, Chenyu; Li, Chen; Qin, Yanguo; Wang, Zhonghan; Yang, Fan; Li, Zuhao; Wang, Jincheng

doi:10.1039/c7ra13510f

Cited by 576 publications

(299 citation statements)

References 203 publications

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“…[24][25][26][27][28] Various approaches have been used to prepare chitosan-based nanocarriers, including emulsified solvent diffusion, ionic gelation, microemulsion, reverse micelle formation, complex coacervation, and polyelectrolyte complexation (PEC). [24][25][26][27][28] Various approaches have been used to prepare chitosan-based nanocarriers, including emulsified solvent diffusion, ionic gelation, microemulsion, reverse micelle formation, complex coacervation, and polyelectrolyte complexation (PEC).…”

Section: Strategies For Intracellular Protein Deliverymentioning

confidence: 99%

Rational Design of Nanocarriers for Intracellular Protein Delivery

et al. 2019

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Protein/antibody therapeutics have exhibited the advantages of high specificity and activity even at an extremely low concentration compared to small molecule drugs. However, they are accompanied by unfavorable physicochemical properties such as fragile tertiary structure, large molecular size, and poor penetration of the membrane, and thus the clinical use of protein drugs is hindered by inefficient delivery of proteins into the host cells. To overcome the challenges associated with protein therapeutics and enhance their biopharmaceutical applications, various protein‐loaded nanocarriers with desired functions, such as lipid nanocapsules, polymeric nanoparticles, inorganic nanoparticles, and peptides, are developed. In this review, the different strategies for intracellular delivery of proteins are comprehensively summarized. Their designed routes, mechanisms of action, and potential therapeutics in live cells or in vivo are discussed in detail. Furthermore, the perspective on the new generation of delivery systems toward the emerging area of protein‐based therapeutics is presented as well.

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Section: Strategies For Intracellular Protein Deliverymentioning

confidence: 99%

Rational Design of Nanocarriers for Intracellular Protein Delivery

et al. 2019

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“…Human skin is the most important and the largest organ of the human body. 1 It acts as a barrier against the invasion of pathogens, such as bacteria and fungi colonization. 2,3 Wounds to the skin are classied as acute, such as those due to burns, trauma, and abrasions, or chronic, such as the case with diabetic foot ulcers.…”

Section: Introductionmentioning

confidence: 99%

Chemisorption and sustained release of cefotaxime between a layered double hydroxide and polyvinyl alcohol nanofibers for enhanced efficacy against second degree burn wound infection

et al. 2020

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“…Ideal wound dressing should be biocompatible and provide an optimal wound healing environment by absorbing excess exudate and toxins, keeping moisture balance, allowing gaseous exchange and discouraging microorganism entrance . Wound dressings have been constructed by both synthetic and natural polymers or their blends in different forms such as sponges, films, hydrogels, hydrocolloids, and membranes . Sponge dressings are generally preferred since their high porosity allows gas permeability, controlled water vapor evaporation, and wound exudate absorption, which keeps wounds in moist environment .…”

Section: Introductionmentioning

confidence: 99%

Construction of a sandwich‐type wound dressing with pain‐reliever and pH‐responsive antibiotic delivery system

Ozdabak‐Sert

Sen

Kök

2019

J of Applied Polymer Sci

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A multifunctional sandwich type wound dressing was designed in which two types of microspheres, one to alleviate the pain (ibuprofen) and the other to protect the wound from infections (Gentamicin or Ciprofloxacin), were embedded into bilayer chitosan sponge. pH of the wound increases from acidic (pH~5) to basic (pH~8) via infection, so pH-dependent antibiotic release system was designed using gelatin B microspheres to respond to increasing pH. Ibuprofen release from chitosan microspheres, on the other hand, was pH-independent not to intervene with pain management in changing pH conditions. Crosslinking with glutaraldehyde (GA) affected both release profile and size distribution of microspheres and 2.5% GA was chosen to obtain pH-responsive gelatin microspheres with narrow size distribution (80% of microspheres in between 15 and 25 μm). The final system was found to be effective against both Staphylococcus aureus and Escherichia coli and changing pH seemed to affect the antimicrobial agent delivery as desired.

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A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing

Abstract: Functional active wound dressings are expected to provide a moist wound environment, offer protection from secondary infections, remove wound exudate and accelerate tissue regeneration, as well as to improve the efficiency of wound healing.

Cited by 576 publications

References 203 publications

Rational Design of Nanocarriers for Intracellular Protein Delivery

Rational Design of Nanocarriers for Intracellular Protein Delivery

Chemisorption and sustained release of cefotaxime between a layered double hydroxide and polyvinyl alcohol nanofibers for enhanced efficacy against second degree burn wound infection

Construction of a sandwich‐type wound dressing with pain‐reliever and pH‐responsive antibiotic delivery system

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