A flow injection system with in-series ultraviolet and electrochemical detection for the simultaneous determination of lovastatin and butylated hydroxyanisole in a tablet

Development of methodologies based on HPLC and Raman spectroscopy for monitoring the stability of lovastatin in solid state in the presence of gallic acid

“…Lovastatin, y = 76.59x + 70.90 r = 0.9998 (5) Gallic acid, y = 44.56x + 25.67 r = 0.9991 (6) They were consistently linear in the already mentioned range for both compounds. The minimum detectable level, LOD, and minimum quantitation level, LOQ, defined as: LOD = 3S y/x /m, LOQ = 10S y/x /m, respectively, where S y/x is the residual standard deviation and m is the calculated slope of the corresponding calibration [17], can be found in Table 1.…”

“…The identification of lovastatin, according to USP 23, can be accomplished by matching the infrared absorption and/or ultraviolet absorption spectrum with that of "USP lovastatin RS" [3]. Usage of HPLC for quantitative purposes is not only destructive for the sample but also time consuming and cumbersome since extensive sample preparation is needed [6][7][8][9][10]. An effort to devise a rapid methodology for verification of both identity and content of drug formulations containing lovastatin was reported several years ago by using the mid-infrared spectroscopy [11].…”

Development and Validation of Liquid Chromatographic Method for the Simultaneous Estimation of Ezetimibe and Lovastatin in Human Plasma

“…Lovastatin is isolated from a Monascus and a strain of aspergillus terreus [14][15] . A number of analytical methods have already been published for the determination of Lovastatin in pharmaceutical formulations and in biological samples [16][17][18][19][20][21][22][23][24][25][26] . The combination therapy of ezetimibe with any statin is FDA approved and with this additional 12% to 21% absolute LDL cholesterol is reduced 27 .…”