A Flexible Fluorescent Zr Carboxylate Metal–Organic Framework for the Detection of Electron-Rich Molecules in Solution

Abstract

A novel Zr(IV) dicarboxylate metal organic framework (MOF) built up from an s-tetrazine derived ligand was prepared. This solid, which exhibits a diamond type network, combines a good stability in water, a structural flexibility, and fluorescence properties thanks to the organic ligand. It is noteworthy that this fluorescence is quenched when exposed to electron-rich molecules in solution, such as amines or phenol, this phenomenon being associated with the adsorption of the quencher, as unambiguously proven by X-ray diffraction (XRD) analysis. Finally, the quenching efficiency is shown to be governed not only by electronic and steric factors but also by the relative polarity of the solvent, the MOF, and the quencher. This work thus suggests that it is possible to develop new MOF-based sensors presenting in a given medium (such as water) highly selective responses.

Ln‐MOF Based Ratiometric Luminescent Sensor for the Detection of Potential COVID‐19 Drugs

“…Metal-organic frameworks (MOFs) or porous crystalline hybrid solids, are formed by the coordination between organic ligands and metal cations, oxo-clusters or chains. [5] They exhibit features such as high porosity, variable structural motifs, [6] adjustable pore size, [7] and are of interest for a broad range of potential applications such as gas sorption and separation, [8] catalysis, [9] biomedicine and sensing [10] among others. Lanthanide metal-organic frameworks (Ln-MOFs), a sub-class of MOFs with a great structural diversity associated in some cases with highly porous frameworks, are promising luminescent sensing materials for chemo-sensing that offer several advantages: (i) lanthanides possess strong and narrow characteristic emission peaks, [11] as well as long luminescence lifetime and high quantum yield.…”

A MOF/DNA luminescent sensing platform for detection of potential COVID-19 biomarkers and drugs

“…Furthermore, due to a faster mass diffusion, nanoparticles of MOFs, also denoted nanoMOFs, have been shown to exhibit superior performances for adsorption, membrane design, and sensing [10][11][12][13] . Moreover, defective A conventional strategy to detect a specific biomarker is to select an aptamer functionalized with a luminescent dye such as carboxyl fluorescein1 [11][12][13][14][15][16][17][18][19][20][21][22] . To produce highly effective aptamer sensors, the secondary structure of nucleic acids in aptamer plays an essential role in their biological functions in vivo.…”

1,2,4,5-Tetrazine based ligands and complexes

“…Later on, in 2017, the synthesis and characterization of a Zr(IV) MOF with a s-tetrazine dicarboxylic acid (H2STz) were reported by Devic et al 127 The complex, formulated Zr6O8(STz)4(solvent)n, is able to detect electron-rich molecules due to the quenching of its fluorescence, centred on the TTZ ligand.…”