A MOF/DNA luminescent sensing platform for detection of potential COVID-19 biomarkers and drugs

Abstract

COVID-19 has afflicted people’s life worldwide. Interleukin-6 (IL-6) is an important COVID-19 biomarker in human body fluid that can be used as reference to monitor COVID-19 in real-time and therefore...

Metal–Organic Framework-Based Fluorescent Sensors for the Detection of Pharmaceutically Active Compounds

“…This is another drug for COVID-19 treatment that blocks the link between the mature virus and the host cell and limits the spread of virus replication . Oseltamivir can have dangerous side effects if it is used excessively, including vomiting, nausea, gastrointestinal distress, diarrhea, respiratory problems such as coughing and bronchitis, and central nervous system problems such as insomnia, headache, and dizziness . Therefore, low-cost, real-time detection of oseltamivir in trace levels in various body fluids is very important to stop the spread of diseases that occurs due to the side effects of this drug.…”

“…A 5-(4-(imidazol-1-yl)­phenyl)­isophthalic linker-containing yttrium–organic framework was developed by Serre et al For the selective sensing of this targeted drug, the DNA molecule was functionalized with the MOF. The presence of a large aromatic linker molecule was responsible for the strong binding of DNA via π–π stacking interaction.…”

“…The measured k sv and LOD values of the MOF for the sensing of oseltamivir are 5.6 × 10 5 M –1 and 54 nM, respectively. By the utilization of several instruments and theoretical simulations, the authors concluded that FRET is the possible reason for the reduction in PL intensity of the MOF in the presence of oseltamivir …”

A novel design of superparamagnetic iron oxide-based metal–organic framework for SSI-assisted drug delivery system

“…9 There is a wide range of applications of MOFs in gas storage and separation, catalysis, sensing, and drug delivery. 10–13 In 2006, Férey et al first discovered that MOFs have great potential in DDSs owing to their highly porous structure. 14 Subsequently, Xu et al reported the synthesis of a folic acid-modified UiO-66, which could produce a large amount of 1 O 2 at a specific light wavelength after laser radiation.…”

Lanthanide MOF-based luminescent sensor arrays for the detection of castration-resistant prostate cancer curing drugs and biomarkers

“…16 Lanthanide metal–organic frameworks (Ln-MOFs) are 3D crystalline solids built from the assembly of organic linkers and Ln 3+ cations that are attractive luminescent materials for sensing due to their remarkable luminescence properties such as large Stokes shift, high quantum yield and long lifetime. 17–19 For example, Zeng et al 20 reported a single bimetallic Ln-MOF called Tb/Eu(BTB) (BTB = 1,3,5-benzenetribenzoic acid) as a powerful, versatile probe for fast and facile decoding of homologues, isomers, enantiomers, and even deuterated isotopomers with an energy transfer efficiency between Tb 3+ –Eu 3+ of 69%. However, single emission-based Ln-MOFs suffer from drawbacks such as unstable luminescence emission signals and possible perturbations from the external environment.…”