A family-based association study of T1945C polymorphism in the proline dehydrogenase gene and schizophrenia in the Chinese population

Fan, Jinbo; Ma, Jie; Zhang, Chang Shun; Gu, Ning; Feng, G.; Clair, David St; He, Lin

doi:10.1016/s0304-3940(02)01362-9

Cited by 33 publications

(15 citation statements)

References 18 publications

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“…However, most replication studies detect no association between psychotic phenotypes, primarily schizophrenia, and common PRODH2 polymorphisms. 20 Association with a third locus in the deletion region, ZDHHC8, was detected by the same group that reported originally on PRODH2. 21 Again, follow-up reports have been mixed, but generally have not supported this association.…”

Section: Prodh2 and Zdhhc8mentioning

confidence: 68%

Molecular genetic studies of schizophrenia

2006

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Section: Prodh2 and Zdhhc8mentioning

confidence: 68%

Molecular genetic studies of schizophrenia

2006

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“…An interesting candidate gene in the vicinity of D16Mit100 is the reticulon 4 receptor gene (Rtn4R), located 6.1 Mb from the peak. In humans, this gene is located at 22q11 (Sinibaldi et al, 2004), near the recent schizophrenia candidate genes encoding PRODH and COMT (Fan et al, 2003;Williams et al, 2003;Lee et al, 2005). Rtn4R is an attractive candidate gene, as it has been observed to play a role in the inhibition of neurite elongation (Oertle et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Quantitative trait loci linked to thalamus and cortex gray matter volumes in BXD recombinant inbred mice

et al. 2007

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To investigate whether there are separate or shared genetic influences on the development of the thalamus and cerebral cortex, we identified quantitative trait loci (QTLs) for relevant structural volumes in BXD recombinant inbred (RI) strains of mice. In 34 BXD RI strains and two parental strains (C57BL/ 6J and DBA/2J), we measured the volumes of the entire thalamus and cortex gray matter using point counting and Cavalieri's rule. Heritability was calculated using analysis of variance (ANOVA), and QTL analysis was carried out using WebQTL (http://www.genenetwork.org). The heritability of thalamus volume was 36%, and three suggestive QTLs for thalamus volume were identified on chromosomes 10, 11 and 16. The heritability of cortical gray matter was 43%, and four suggestive QTLs for cortex gray matter volume were identified on chromosomes 2, 8, 16 and 19. The genetic correlation between thalamus and cortex gray matter volumes was 0.64. Also, a single QTL on chromosome 16 (D16Mit100) was identified for thalamus volume, cortex gray matter volume and Morris water maze search-time preference (r ¼ 0.71). These results suggest that there are separate and shared genetic influences on the development of the thalamus and cerebral cortex.

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“…Funke step in the conversion of proline to the neurotransmitter glutamate (30). Mouse studies support a role in schizophrenia (31,32), and population studies have found an association of PRODH variants with the disorder (33,34), but overall, evidence from population studies is still controversial (35)(36)(37). Catechol-Omethyltransferase (COMT) inactivates catecholamine neurotransmitters (dopamine, noradrenalin, and adrenaline) by transferring a methyl group from S-adenosyl methionine (38).…”

Section: Introductionmentioning

confidence: 99%