A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems

Wang, Hui; Yang, Haifeng; Zhao, Lu

doi:10.3390/ma12233978

Cited by 6 publications

(5 citation statements)

References 52 publications

(67 reference statements)

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“…The X‐ray diffraction (XRD) pattern of Pd−Zn@MS was shown in Figure 2a, and there is an obvious wide diffraction peak in the range from 15° to 30°, which is the characteristic “steamed bread peak” of silica on the outer layer of Pd−Zn@MS [36] . Meanwhile, the diffraction peaks corresponding to the (111) and (200) crystal planes of PdZn alloy can be found at 41.2° and 44.1° (Pd 1 Zn 1 , PDF#06‐0620) [37] .…”

Section: Resultsmentioning

confidence: 99%

Pd−Zn Alloy Nanoparticles Encapsulated into Mesoporous Silica with Confinement Effect for Highly Selective Semi‐Hydrogenation of Phenylacetylene

Liu

et al. 2020

ChemCatChem

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In the process of hydrogenation of phenylacetylene to styrene, it is a crucial step to improve the reaction selectivity of the target product styrene. Herein, we have designed the Pd−Zn alloy nanoparticles encapsulated into mesoporous silica with confinement effect (Pd−Zn@MS) for highly selective semi‐hydrogenation of phenylacetylene via annealing the Pd NPs@ZIF‐8 in reducing atmosphere. The as‐obtained Pd−Zn@MS achieved up to the 95 % of conversion rate and 92 % of selectivity, because the mesoporous silica exhibits a steric hindrance effect for the reactant molecular size, and the Pd−Zn alloy nanoparticles shows the high selectivity for the target product styrene. DFT calculations demonstrates that the PdZn alloy nanoparticles can reduce significantly the desorption energy barrier of styrene from 1.72 eV to 0.95 eV, compared with the Pd nanoparticles. Meanwhile the mesoporous silica in the outer layer greatly guarantees the stability of the catalytic performance of the catalyst, and the catalytic performance did not drop after the five‐cycle test. This work provides a new idea for the selective hydrogenation of phenylacetylene and the process of limited‐area catalysis.

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Section: Resultsmentioning

confidence: 99%

Pd−Zn Alloy Nanoparticles Encapsulated into Mesoporous Silica with Confinement Effect for Highly Selective Semi‐Hydrogenation of Phenylacetylene

Liu

et al. 2020

ChemCatChem

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“…In addition, the weak peak at 1532 cm –1 was ascribed to the secondary amide N–H bending, and the N–H vibration peak could be observed at 814 cm –1 as well. Moreover, the C–N tensile peak and Si–O–C peak arose at 1456 and 1072 cm –1 , respectively. − These results vividly demonstrated that the GO was modified by GPTS and the nanocomposite SiO 2 -GO was prepared.…”

Section: Resultsmentioning

confidence: 77%

“…Moreover, the C–N tensile peak and Si–O–C peak arose at 1456 and 1072 cm –1 , respectively. 29 − 32 These results vividly demonstrated that the GO was modified by GPTS and the nanocomposite SiO 2 -GO was prepared.…”

Section: Resultsmentioning

confidence: 77%

Difunctional Silicon Dioxide Combined with Graphene Oxide Nanocomposite to Enhance the Anticorrosion Performance of Epoxy Coatings

et al. 2022

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The nanocomposite BTA-SiO 2 -GO was fabricated for the purpose of metal corrosion protection. Herein, the BTA-loaded mesoporous silica nanocontainers were prepared through a facile one-step synthetic method. Subsequently, graphene oxide (GO) was combined with the resultant BTA-SiO 2 compound because GO had a superior barrier property and impermeability. We must note that the double functional groups exist on SiO 2 . Benzotriazole (BTA), as an inhibitor, can be loaded into the nanocontainer and GO can also be modified by it, resulting in excellent dispersion in epoxy coatings, which were conducive to enhancing its anticorrosion performance. In this way, the nanocomposite endows the coating system with both self-healing and physical barrier abilities. The EIS results indicated that the impedance value of the BTA-SiO 2 -GO composite coatings was up to 1.2 × 10 9 Ω cm 2 , which indicated excellent corrosion resistant properties.

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“…The addition of a small amount of ultrafine silica could change the dissolution rate of griseofulvin, which could highly enhance the dispersibility of insoluble drugs in water ( Rojas and Kumar, 2011 ). SiO 2 nanospheres (SiO 2 NPs) had significantly increased the loading capacity of layered copper hydroxybenzoate and prolonged the release time ( Wang et al, 2019 ). However, to our best knowledge, there are few reports on SiO 2 NPs as nanocarrier to delivering gatifloxacin, motivating us to explore the effect of SiO 2 NPs on the antibacterial activity of gatifloxacin.…”

Section: Introductionmentioning

confidence: 99%

Design of a Controlled-Release Delivery Composite of Antibacterial Agent Gatifloxacin by Spherical Silica Nanocarrier

Guo

Zhang

et al. 2022

Front. Chem.

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In this study, a spherical silica nanoparticle was explored as a gatifloxacin carrier synthesized by the chemical precipitation method. It was found that there was no new chemical bond formation during the loading process between gatifloxacin and silica, which implies that the binding was driven by physical interaction. In addition, the drug loading and encapsulation efficiency could be improved by appropriately increasing nano-silica content in the loading process. Meanwhile, the release rate of gatifloxacin after loading nano-silica was also improved, suggesting the successful design of a controlled-release delivery composite. The silica nanocarrier could significantly improve the antibacterial performance of Escherichia coli by 2.1 times, which was higher than the pure gatifloxacin. The 24 h bacteriostatic rate was higher than that of a simple mixture of silica nanoparticles and gatifloxacin. Strong reactive oxygen species (ROS) in GAT-SiO2 NPs suggests that ROS might be associated with bactericidal activity. The synergy between the physicochemical effect and ROS production of this material is proposed as the mechanism of its antibacterial activity, which can also be confirmed by the cell membrane damage observed under electron microscopy and DNA damage experiments. Collectively, our finding indicates that nano-silica microspheres could serve as a promising carrier for the sustained release of gatifloxacin, thereby providing a new carrier design scheme for the improvement of the antibacterial effect.

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A Facile Synthesis of Core-Shell SiO2@Cu-LBMS Nano-Microspheres for Drug Sustained Release Systems

Cited by 6 publications

References 52 publications

Pd−Zn Alloy Nanoparticles Encapsulated into Mesoporous Silica with Confinement Effect for Highly Selective Semi‐Hydrogenation of Phenylacetylene

Pd−Zn Alloy Nanoparticles Encapsulated into Mesoporous Silica with Confinement Effect for Highly Selective Semi‐Hydrogenation of Phenylacetylene

Difunctional Silicon Dioxide Combined with Graphene Oxide Nanocomposite to Enhance the Anticorrosion Performance of Epoxy Coatings

Design of a Controlled-Release Delivery Composite of Antibacterial Agent Gatifloxacin by Spherical Silica Nanocarrier

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