A Facile One-pot Synthesis of Pyrido[2,3-d]pyrimidines and Pyrido[2,3-d:6,5-d′]dipyrimidines

Abstract

The reactions of enaminones (6-aminouracils) 1a±c and 4 with cyano olefins 2a±b and 5a±f led to the formation of pyrido[2,3-d ]pyrimidines 3a±f and 6a±f in good yield, while the treatment of 4-amino-2-thiouracil 4 with aromatic aldehydes afforded pyridodipyrimidines 7a±c.

Cyclocondensation Reactions of Hydrazonoyl Chlorides with Some Azines: Synthesis of New Fused Heterocycles of Expected Microbiological Activity

“…Also the reaction of 6-aminouracil-2-thione (2) with benzaldehyde in acetic acid afforded the compound 10 [39], which reacted with hydrazonoyl chloride (1a) to yield the product 6a [22] (Scheme 3). The product 6a obtained by the alternate synthesis found to be identical in all respects (mp, mixed mp, IR and 1 HNMR) with the product produced from the reaction of 5 with 1a in Scheme 1.…”

A Greener and Rapid Approach for Synthesis of Pyranopyrroles using Nano ZnO as an efficient Catalyst

“…Multi component reactions (MCRs) involving a cascade process with more than two different substrates to generate complex molecular frameworks have emerged as a powerful synthetic strategy. The development of efficient and eco-friendly synthetic methodologies for the rapid construction of potentially bioactive compounds became a major task for chemists in organic synthesis [1][2][3][4][5][6]. Among the multi-component reactions [7].…”

Recent Developments in the MCRs Synthesis of Pyridopyrimidines and Spiro‐Pyridopyrimidines

“…Pyrido[2,3‐ d ]pyrimidine derivatives possess wide range of physiological properties, which include antiviral , antibacterial , diuretic, analgesic , anticonvulsive , anti‐inflammatory , antipyretic , cardiotonic , antitumoral , antihistaminic , bactericidal , bronchiodilator , and also act as a cyclin‐dependent kinase 4 inhibitor . Pyrido[3,2‐ d ]pyrimidines act as dihydrofolate reductase inhibitors and tyrosine kinase inhibitors .…”