Recent Developments in the MCRs Synthesis of Pyridopyrimidines and Spiro‐Pyridopyrimidines

Abstract

Because of biological and medicinal properties of pyridopyrimidines, synthesis of these heterocycles has attracted the interest of organic and medicinal chemists. This review focuses on the recent development in the multi‐component synthesis of pyridopyrimidine and spiro‐conjugated pyridopyrimidine systems. The present review describes the literature reports for the period 2000–2015, particularly those that involve the reactions of activated methylene, aldehyde or ketone, and amine in classical and nonclassical conditions.

The Beneficial Sinergy of MW Irradiation and Ionic Liquids in Catalysis of Organic Reactions

“…For example, the Mannich reaction, i.e., the formation of β-amino carbonyl compounds from a non-enolizable aldehyde with an enolizable carbonyl compound and an amine (either primary or secondary), was thoroughly examined, also in view of the opportunity to be involved in tandem or cascade processes, with consequent high atom economy, as discussed in recent reviews [133][134][135].…”

Simple synthesis of new imidazopyridinone, pyridopyrimidinone, and thiazolopyridinone derivatives and optimization of reaction parameters using response surface methodology

“…[7][8][9][10] Among these heterocycles, pyridine derivatives, such as imidazopyridine, pyridopyrimidine, and thiazolopyridine derivatives have received considerable attention over the past years due to their diverse biological activities and clinical applications. 11,12 Imidazopyridine derivatives have shown a broad range of interesting biological activities, such as antifungal, antitumor, antiviral, antibacterial, anti-HIV, 13 antipyretic, analgesic, hypnoselective, anxioselective, anti-inammatory, anticonvulsant, antiulcer, immunomodulatory 14 activities; also pyridopyrimidine derivatives 15 are found to exhibit a broad spectrum of potent antibacterial, antiallergic, antimicrobial, 12 anti-inammatory, analgesic, 16,17 tyrosine kinase, calcium channel antagonists, 8,18 tuberculostatic, antileishmanial, antitumor, 19 antifolate, antihypertensive, hepatoprotective, 20 anticancer 21 properties; and thiazolopyridine derivatives are associated with a wide range of biological activities such as analgesic, antioxidant, 11 anticancer, 22 anti-inammatory, 23 antihypertensive, 24 antibacterial, and antifungal 25,26 properties.…”

Metal‐Free Assemblage of Four C−N and Two C−C Bonds via a Cascade Five Component Diastereoselective Synthesis of Pyrido[1,2‐a]Pyrimidines

“…Fused pyrimidine systems in general and pyridopyrimidines in particular have received most of synthetic organic chemists attention for their biological potencies and chemotherapeutic properties. They have broad spectrum of pharmaceutical applications such as anticancer, antioxidant, anti‐inflammatory, antiviral, antimicrobial, and more importantly they are found as the backbones of several medications . Among them, pyrido[1,2‐a]pyrimidines exist in the structure of several prescribed drugs such as the tranquilizer, pirenperone, antiasthmatic agent, pemirolast, antiallergic agent, barmastine, and antiulcerativeagent .…”

“…They have broad spectrum of pharmaceutical applications such as anticancer, antioxidant, anti-inflammatory, antiviral, antimicrobial, and more importantly they are found as the backbones of several medications. [2] Among them, pyrido [1,2-a]pyrimidines exist in the structure of several prescribed drugs such as the tranquilizer, pirenperone, [3] antiasthmatic agent, pemirolast, [4] antiallergic agent, barmastine, [5] and antiulcerativeagent. [6] They are also renowned for their antidepressant, [7] stress-protecting, [8] gastrointestinal protective, [9] neurotropic, and anticancer properties.…”