Due to biological and medicinal properties of pyranopyrazoles, synthesis of these bioactive heterocycles has attracted the interest of medicinal and organic chemists. This review focuses on the recent developments in multicomponent synthesis of pyranopyrazole and spiroconjugated pyranopyrazole systems. The present review describes the literature reports for the period 2005 to 2018. These reported approaches were performed in the classical and nonclassical conditions, particularly recent reports includes protocols under a green condition such as using catalyst, green solvents, and solvent-free conditions. ARTICLE HISTORY

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Because of biological and medicinal properties of pyridopyrimidines, synthesis of these heterocycles has attracted the interest of organic and medicinal chemists. This review focuses on the recent development in the multi‐component synthesis of pyridopyrimidine and spiro‐conjugated pyridopyrimidine systems. The present review describes the literature reports for the period 2000–2015, particularly those that involve the reactions of activated methylene, aldehyde or ketone, and amine in classical and nonclassical conditions.

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In recent years, heterogeneous catalysts have been extensively employed to speed up organic reactions. The key advantages of these catalysts are environmental compatibility, operational simplicity, nontoxicity, easy of separation from the reaction mixture and low cost. 1,2 The efficiency of heterogeneous catalysis in organic synthesis can be improved by employing nano scale catalysts because nanoparticles have a high specific surface area, leading to an increase of contact with the reactants. 3 They generally exhibit higher catalytic activity than conventional heterogeneous acid catalysts. One particularly useful and important group of nanoparticles is magnetic nanoparticles.Because of versatile biological and medicinal properties of pyridopyrimidines, their synthesis has attracted the interest of many organic chemists. The pyrido [2,3-d]pyrimidine structural moeity is found in a large number of pharmaceutical agents which exhibit a diverse range of physiological activities such as antibacterial, 4 antiviral, 5 diuretic, analgesic, 6 anticonvulsive, 7,8 antipyretic, 9 anti-inflammatory, 10 antitumoral, 11 antihistaminic, 12 cardiotonic, 13,14 and bactericidal. 15 They also have bronchiodilator 16 activity and can act as a cyclin-dependent kinase 4 inhibitor. 17