A facile approach for the fabrication of core–shell PEDOT nanofiber mats with superior mechanical properties and biocompatibility

Jin, Lin; Wang, Ting; Feng, Zhang‐Qi; Leach, Michelle K.; Wu, Jindi; Mo, Shi-Jing; Jiang, Qing

doi:10.1039/c3tb00448a

Cited by 82 publications

(73 citation statements)

References 56 publications

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“…Since the sonication process decreased the conductivity and the addition of MWCNT did not significantly increase the conductivity, only the 1:10, 1:2, 3:4, and 1:1 PCL‐PEDOT scaffolds were tested for cytocompatibility with rat primary skeletal muscle cells. PEDOT has been known to have poor cytocompatibility which is why we used small amounts with the PCL solution . Over the 4‐week period, metabolic activity increased on all four scaffolds; however, the metabolic activity of the rat muscle cells on the 3:4 scaffolds was significantly lower on day 28 than the other groups on day 28 (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Jin et al cultured human cancer stem cells (hCSCs) on electrospun PVA‐PEDOT core‐shell fibers. The hCSCs cultured on the PVA‐PEDOT fibers displayed similar morphology and attachment as those cultured on TCP . Feng et al cultured dorsal root ganglia (DRG) on PEDOT microfibers and showed that the neurites followed the PEDOT fiber alignment and exhibited the classic spindle‐shaped morphology.…”

Section: Discussionmentioning

confidence: 99%

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Poly(3,4‐ethylenedioxythiophene) nanoparticle and poly(ɛ‐caprolactone) electrospun scaffold characterization for skeletal muscle regeneration

Fischer

Browe

Olabisi

et al. 2015

J Biomedical Materials Res

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Injuries to peripheral nerves and/or skeletal muscle can cause scar tissue formation and loss of function. The focus of this article is the creation of a conductive, biocompatible scaffold with appropriate mechanical properties to regenerate skeletal muscle. Poly(3,4-ethylenedioxythiophene) (PEDOT) nanoparticles (Np) were electrospun with poly(ɛ-caprolactone) (PCL) to form conductive scaffolds. During electrospinning, ribboning, larger fiber diameters, and unaligned scaffolds were observed with increasing PEDOT amounts. To address this, PEDOT Np were sonicated prior to electrospinning, which resulted in decreased conductivity and increased mechanical properties. Multi-walled carbon nanotubes (MWCNT) were added to the 1:2 solution in an effort to increase conductivity. However, the addition of MWCNT had little effect on scaffold conductivity, and the elastic modulus and yield stress of the scaffold increased as a result. Rat muscle cells attached and were active on the 1-10, 1-2, 3-4, and 1-1 PCL-PEDOT scaffolds; however, the 3-4 scaffolds had the lowest level of metabolic activity. Although the scaffolds were cytocompatible, further development of the fabrication method is necessary to produce more highly aligned scaffolds capable of promoting skeletal muscle cell alignment and eventual regeneration.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Poly(3,4‐ethylenedioxythiophene) nanoparticle and poly(ɛ‐caprolactone) electrospun scaffold characterization for skeletal muscle regeneration

Fischer

Browe

Olabisi

et al. 2015

J Biomedical Materials Res

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show abstract

“…[ 20 ] This electrical performance was much higher than that of the commonly used e-NFs for cellular electrical stimulation such as conductive polymer nanofi bers (≈5.5 S cm −1 ). [29][30][31] The excellent electrical conductivity was contributed by the formation of graphene shells on the surface of nanofi bers with the spatial continuous graphene sheets. In addition, in this coupled material system, no polymeric insulator obstructs the 2D confi ned pseudoballistic electronic transports among the G-NFs, which often occurred in other conductive materials doped nanofi bers.…”

Section: Doi: 101002/adma201503319mentioning

confidence: 99%

Soft Graphene Nanofibers Designed for the Acceleration of Nerve Growth and Development

et al. 2015

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Soft graphene nanofibers with recoverable electrical conductivity and excellent physicochemical stability are prepared by a controlled assembly technique. By using the soft graphene nanofibers for cellular electrical stimulation, the common inhibitory effect of long-term electrical stimulation on nerve growth and development is avoided, which usually happens with traditional 2D conductive materials.

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“…Then, the obtained scaffolds were cut into 24‐well plates by a sterile razor and sterilized under UV for 30 min prior to cell seeding. Finally, hMSCs were seeded on/in these scaffolds for biocompatibility tests with medium changing cycle/intervals of 2 d until the final observation day …”

Section: Methodsmentioning

confidence: 99%

Engineering 3D Aligned Nanofibers for Regulation of Cell Growth Behavior

Jin

et al. 2017

Macro Materials & Eng

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3D aligned electrospun fibers hold a promising potential in a wide range of biomedical areas, including biosensors, controlled drug release, tissue engineering, etc. Thus, a cost‐effective and easy way to scale‐up fabrication for 3D aligned nanofibers is highly desired. Herein, a novel yet facile preparation process of 3D aligned nanofibers (3D AFs) by an improved electrospinning technique is reported. The obtained 3D AFs show enhanced controllability on morphology and fiber density, and thus facilitate adhesion and growth of human mesenchymal stem cells within their 3D nanofiber microarchitectures, leading to an excellent in vitro biocompatibility. Moreover, the 3D AFs with aligned morphology can enhance the neuron activities and induce directional cell growth along the direction of nanofiber orientation, thereby providing an excellent cue for the anchorage and migration dependent neurons. Combined with controllable morphology and structure, it is anticipated that this finding can lead to great applications of electrospun fibers in nerve tissue engineering, diagnostics, and other biomedical fields.

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A facile approach for the fabrication of core–shell PEDOT nanofiber mats with superior mechanical properties and biocompatibility

Cited by 82 publications

References 56 publications

Poly(3,4‐ethylenedioxythiophene) nanoparticle and poly(ɛ‐caprolactone) electrospun scaffold characterization for skeletal muscle regeneration

Poly(3,4‐ethylenedioxythiophene) nanoparticle and poly(ɛ‐caprolactone) electrospun scaffold characterization for skeletal muscle regeneration

Soft Graphene Nanofibers Designed for the Acceleration of Nerve Growth and Development

Engineering 3D Aligned Nanofibers for Regulation of Cell Growth Behavior

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