A Dynamic Artificial Gastrointestinal System for Studying the Behavior of Orally Administered Drug Dosage Forms Under Various Physiological Conditions

Blanquet, S.; Zeijdner, Evelijn; Beyssac, Eric; Meunier, Jean-Philippe; Denis, Sylvain; Havenaar, R.; Alric, Monique

doi:10.1023/b:pham.0000022404.70478.4b

Cited by 256 publications

(201 citation statements)

References 20 publications

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“…absorption and diffusion) and rheological aspects (i.e. mixing) (Blanquet et al, 2004;Dekkers, Kolodziejczyk, Acquistapace, Engmann, & Wooster, 2016;Kong & Singh, 2010a;Levi & Lesmes, 2014;Mercuri, Lo Curto, Wickham, Craig, & Barker, 2008;Shani-Levi, Levi-Tal, & Lesmes, 2013;Tharakan, Norton, Fryer, & Bakalis, 2010;Yoo & Chen, 2006). To date, both advanced and simple IVD models have be used to investigate a variety of systems.…”

Section: Current Status Of Adult In Vitro Digestion (Ivd) Modelsmentioning

confidence: 99%

“…viscosity or gelling) and with consumer parameters, such as age and health (e.g. 2h for healthy adult and 3h for infant (Blanquet et al, 2004)). …”

Section: Small Intestinal Phasementioning

confidence: 99%

“…Based on the current physiological knowledge of the infant GI, various static and dynamic IVD models have been applied by researchers (Blanquet et al, 2004;de Oliveira et al, 2015;Dupont et al, 2010a;Roussel et al, 2016;Shani-Levi et al, 2013). Yet, the development of a harmonized static infant IVD is needed.…”

Section: Infantsmentioning

confidence: 99%

“…Further, there are some dynamic IVD models described in recent literature (Blanquet et al, 2004;Havenaar et al, 2013;Menard et al, 1995;Menard et al, 2014;de Oliveira et al, 2015;Roussel et al, 2016;Shani-Levi et al, 2013). In essence, these models try to recreate some of the dynamic aspects of digestion, e.g.…”

Section: Infantsmentioning

confidence: 99%

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Extending in vitro digestion models to specific human populations: Perspectives, practical tools and bio-relevant information

Shani-Levi

Alvito

Andrés

et al. 2017

Trends in Food Science & Technology

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147

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a b s t r a c tBackground: In vitro digestion models show great promise in facilitating the rationale design of foods. This paper provides a look into the current state of the art and outlines possible future paths for developments of digestion models recreating the diverse physiological conditions of specific groups of the human population. Scope and approach: Based on a collective effort of experts, this paper outlines considerations and parameters needed for development of new in vitro digestion models, e.g. gastric pH, enzymatic activities, gastric emptying rate and more. These and other parameters are detrimental to the adequate development of in vitro models that enable deeper insight into matters of food luminal breakdown as well as nutrient and nutraceutical bioaccessibility. Subsequently, we present an overview of some new and emerging in vitro digestion models mirroring the gastro-intestinal conditions of infants, the elderly and patients of cystic fibrosis or gastric bypass surgery. Key findings and conclusions: This paper calls for synchronization, harmonization and validation of potential developments in in vitro digestion models that would greatly facilitate manufacturing of foods tailored or even personalized, to a certain extent, to various strata of the human population.

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Section: Current Status Of Adult In Vitro Digestion (Ivd) Modelsmentioning

confidence: 99%

“…viscosity or gelling) and with consumer parameters, such as age and health (e.g. 2h for healthy adult and 3h for infant (Blanquet et al, 2004)). …”

Section: Small Intestinal Phasementioning

confidence: 99%

Section: Infantsmentioning

confidence: 99%

Section: Infantsmentioning

confidence: 99%

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Extending in vitro digestion models to specific human populations: Perspectives, practical tools and bio-relevant information

Shani-Levi

Alvito

Andrés

et al. 2017

Trends in Food Science & Technology

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147

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“…Tablet thickness is an important characteristic in reproducing appearance. Average thickness of the core and coated tablets is calculated and presented with deviation 16 .…”

Section: Evaluation Of Tablets Weight Variation Testmentioning

confidence: 99%

Formulation and in Vitro Evaluation of Simethicone Tablets as Gasrto Retentive Drug Delivery System

Mangilal¹,

Rao²

2017

Int. Res. J. Pharm.

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ABSTARCTThe aim of the present study was to develop a delayed release formulation of Simethicone to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of HPMC polymers and accrual were employed as polymers. Simethicone dose was fixed at 62.5 mg. The total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 10, 20 and 30 mg concentration and accrual concentration used in the formulations were optimized according to the floating properties of the formulations. All the formulations were passed various physicochemical evaluation parameters like hardness, bulk density, friability, weight variation etc. and they were found to be within limits and also the drug and excipient studies showed that there is no incompatibility between pure drug and excipient. Whereas from the dissolution studies, it was evident that the optimized formulation (F6) showed better and desired drug release pattern i.e.,98.17 % in 12 hours. The optimized formulation dissolution data were subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Higuchi mechanism of drug release.

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RecombinantSaccharomyces Cerevisiaeas New Drug Delivery System to Gut: In Vitro Validation and Oral Formulation

Blanquet

Alric

2010

Pharmaceutical Sciences Encyclopedia

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The development of recombinant deoxyribonucleic acid (DNA) technology has allowed the emergence of novel applications such as drug production directly in the human digestive environment (“in situ”) by ingested living recombinant microorganisms. Genetically engineered microorganisms offer several advantages over classical dosage forms, such as protection of active compounds and regulation of gene expression. This article focuses on the concept and applications of biodrug, scientific feasibility of biodrug concept using yeast as vector, and oral formulation of recombinant yeasts.

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A Dynamic Artificial Gastrointestinal System for Studying the Behavior of Orally Administered Drug Dosage Forms Under Various Physiological Conditions

Abstract: TIM-1 is a powerful tool for supplying valuable information about the effects of various gastrointestinal conditions on biopharmaceutical behavior and efficacy of drug delivery systems in the development of oral formulations.

Cited by 256 publications

References 20 publications

Extending in vitro digestion models to specific human populations: Perspectives, practical tools and bio-relevant information

Extending in vitro digestion models to specific human populations: Perspectives, practical tools and bio-relevant information

Formulation and in Vitro Evaluation of Simethicone Tablets as Gasrto Retentive Drug Delivery System

RecombinantSaccharomyces Cerevisiaeas New Drug Delivery System to Gut: In Vitro Validation and Oral Formulation

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