Formulation and in Vitro Evaluation of Simethicone Tablets as Gasrto Retentive Drug Delivery System

Abstract

ABSTARCTThe aim of the present study was to develop a delayed release formulation of Simethicone to maintain constant therapeutic levels of the drug for over 12 hrs. Various grades of HPMC polymers and accrual were employed as polymers. Simethicone dose was fixed at 62.5 mg. The total weight of the tablet was considered as 300 mg. Polymers were used in the concentration of 10, 20 and 30 mg concentration and accrual concentration used in the formulations were optimized according to the floating properties of the formulations. All the formulations were passed various physicochemical evaluation parameters like hardness, bulk density, friability, weight variation etc. and they were found to be within limits and also the drug and excipient studies showed that there is no incompatibility between pure drug and excipient. Whereas from the dissolution studies, it was evident that the optimized formulation (F6) showed better and desired drug release pattern i.e.,98.17 % in 12 hours. The optimized formulation dissolution data were subjected to release kinetics; from the release kinetics data it was evident that the formulation followed Higuchi mechanism of drug release.