A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia

Hoptman, Matthew J.; Nierenberg, Jay; Bertisch, Hilary; Catalano, Dean; Ardekani, Babak A.; Branch, Craig A.; DeLisi, Lynn E.

doi:10.1016/j.schres.2008.07.023

Cited by 132 publications

(121 citation statements)

References 49 publications

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“…Studying these individuals allows evaluation of the underpinnings of schizophrenia that are independent of the disease state. Many studies have investigated schizophrenic patients and first-degree relatives with DTI, and suggested that patterns of abnormal structural connectivity may be an important endophenotype of schizophrenia [18][19][20][21][22] . Recently, using diffusion-weighted imaging, Collin et al found that the network organization is abnormal in schizophrenia and their unaffected siblings, and suggested that structural connectivity is an indicator of genetic predisposition for schizophrenia [23] .…”

Section: Introductionmentioning

confidence: 99%

Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

et al. 2015

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Several lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly relevant to this pathophysiological process. As a complex mental disorder with high heritability, mapping abnormalities in patients and their firstdegree relatives may help to disentangle the risk factors for schizophrenia. We established a weighted network model of white matter connections using diffusion tensor imaging in 25 nuclear families with schizophrenic probands (19 patients and 41 unaffected parents) and two unrelated groups of normal controls (24 controls matched with patients and 26 controls matched with relatives). The patient group showed lower global efficiency and local efficiency. The decreased regional efficiency was localized in hubs such as the bilateral frontal cortices, bilateral anterior cingulate cortices, and left precuneus. The global effi ciency was negatively correlated with cognition scores derived from a 5-factor model of schizophrenic psychopathology.We also found that unaffected parents displayed decreased regional efficiency in the right temporal cortices, left supplementary motor area, left superior temporal pole, and left thalamus. The global efficiency tended to be lower in unaffected parents. Our data suggest that (1) the global effi ciency loss in neuroanatomical networks may be associated with the cognitive disturbances in schizophrenia; and (2) genetic vulnerability to schizophrenia may influence the anatomical organization of an individual's brain networks.

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Section: Introductionmentioning

confidence: 99%

Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

et al. 2015

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“…While the majority of studies investigating first-degree relatives of schizophrenia patients have revealed decreasing FA in tracts compared to controls (Camchong et al, 2009;Hao et al, 2009;Hoptman et al, 2008;Munoz Maniega et al, 2008), there have been a few studies that have demonstrated increased FA (Boos et al, 2013;Hoptman et al, 2008). One possible explanation for the difference is that previous studies have examined adult relatives of patients with schizophrenia, while the present study tested adolescent relatives.…”

Section: Discussionmentioning

confidence: 75%

“…Gogtay et al (2012) and Moran et al (2015) found a delayed white matter growth trajectory and decreased FA in adolescent COS siblings, Boos et al (2013) and Hoptman et al (2008), found increased FA in adult first-degree relatives of AOS, while others (Harms et al, 2015;Koivukangas et al, 2015) found no differences in AOS relatives compared to controls.…”

Section: Introductionmentioning

confidence: 95%

“…diffusion) by applying many diffusion-encoding gradients in different orientations (Beaulieu, 2002). DTI studies have demonstrated decreased white matter fractional anisotropy (FA) in adult onset schizophrenia (AOS) patients compared to healthy subjects (Camchong et al, 2009;Ellison-Wright and Bullmore, 2009;Hao et al, 2009;Hoptman et al, 2008;Munoz Maniega et al, 2008), though one study (Hoptman et al, 2008) showed an increase in FA.…”

Section: Introductionmentioning

confidence: 99%

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DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia

Waltzman

Knowlton

Cohen

et al. 2016

Psychiatry Research: Neuroimaging

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“…The DTI and DTT results of optic radiation fibers were normal in six patients with optical nerve abnormalities, which suggested that visual pathway lesion was located in periphery instead of visual center. FA derived from the three eigenvalues of the diffusion tensor is the most frequently used parameter obtained from DTI, and is a measure of the degree of diffusion anisotropy within a voxel varying from 0 (corresponding to completely isotropic diffusion) to 1 (corresponding to free diffusion in one direction only) (28). Thus, FA value depends on fiber organization, fiber directional coherence, and/or fiber integrity in white matter (29).…”

Section: Discussionmentioning

confidence: 99%

Visual pathway lesion and its development during hyperbaric oxygen treatment: A bold‐ fMRI and DTI study

Chen

Yang

et al. 2010

Magnetic Resonance Imaging

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Purpose: To characterize and evaluate functional and anatomic changes of visual pathway lesions during hyperbaric oxygen (HBO) treatment with blood-oxygenation-level-dependent functional MRI (BOLD-fMRI) and diffusion tensor imaging (DTI). Materials and Methods:Sixteen patients with visual pathway lesions received HBO treatment. Both BOLDfMRI and DTI were performed before and after the treatment, while 12 healthy subjects were also studied with 2 examinations as control. The t-tests were used for the comparison of number of activated voxels (AVs) and fractional anisotropy (FA) between the two groups, and within the patient group before and after HBO treatment. Visual acuity of the patient group before and after the treatment was compared using Wilcoxon signed-rank test.Results: Before the treatment, both AVs (P < 0.01) and FA (P < 0.05) in the bilateral cortexes of occipital lobes were significantly less in the patient group than in the control group. After the treatment, both AVs (P < 0.05) and FA (P < 0.05) were significantly increased. Moreover, The FA of 6 patients with lesions in the optical nerve was greater than the FA of the other 10 patients with lesions in the optic radiation (P < 0.05).Conclusion: BOLD-fMRI combined with DTI was useful for the characterization and evaluation of anatomic and functional changes of visual pathway lesions and their development during HBO treatment.

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A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia

Cited by 132 publications

References 49 publications

Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia

Visual pathway lesion and its development during hyperbaric oxygen treatment: A bold‐ fMRI and DTI study

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