Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

Yan, Hao; Tian, Lin; Wang, Qifeng; Zhao, Qiang; Yue, Weihua; Yan, Junhao; Liu, Bing; Zhang, Dai

doi:10.1007/s12264-014-1518-0

Cited by 26 publications

(24 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finding no clear changes in hub or rich club connectivity in bipolar I disorder patients is of interest in light of recent findings in schizophrenia indicating a disproportionate disturbance of brain hubs and their mutual connections in schizophrenia patients [Van den Heuvel et al, ] and their unaffected relatives [Collin et al, ; Yan et al, ]. Moreover, it has been proposed that affected hub connectivity may be a general feature of brain disorders [Crossley et al, ].…”

Section: Discussionmentioning

confidence: 99%

Brain network analysis reveals affected connectome structure in bipolar I disorder

et al. 2015

View full text Add to dashboard Cite

The notion of healthy brain function emerging from coordinated neural activity constrained by the brain’s network of anatomical connections – i.e. the connectome – suggests that alterations in the connectome’s wiring pattern may underlie brain disorders. Corroborating this hypothesis, studies in schizophrenia are indicative of altered connectome architecture including reduced communication efficiency, disruptions of central brain hubs and affected ‘rich club’ organization. Whether similar deficits are present in bipolar disorder is currently unknown. This study examines structural connectome topology in 216 bipolar I disorder patients as compared to 144 healthy controls, focusing in particular on central regions (i.e., brain hubs) and connections (i.e., rich club connections, inter-hemispheric connections) of the brain’s network. We find that bipolar I disorder patients exhibit reduced global efficiency (−4.4%, p = 0.002) and that this deficit relates (r = 0.56, p < 0.001) to reduced connectivity strength of inter-hemispheric connections (−13.0%, p = 0.001). Bipolar disorder patients were found not to show predominant alterations in the strength of brain hub connections in general, or of connections spanning brain hubs (i.e., ‘rich club’ connections) in particular (all p > 0.1). These findings highlight a role for aberrant brain network architecture in bipolar I disorder with reduced global efficiency related to disruptions in inter-hemispheric connectivity, while the central ‘rich club’ system appears not to be particularly affected.

show abstract

Section: Discussionmentioning

confidence: 99%

Brain network analysis reveals affected connectome structure in bipolar I disorder

et al. 2015

View full text Add to dashboard Cite

show abstract

“…1, bottom). Disrupted local efficiency has been observed in schizophrenia patients in a number of areas, including the ACC (Smucny and Tregellas, 2013; Yan et al, 2015). …”

Section: Introductionmentioning

confidence: 99%

Nicotinic modulation of salience network connectivity and centrality in schizophrenia

Smucny

Wylie

Kronberg

et al. 2017

Journal of Psychiatric Research

View full text Add to dashboard Cite

Although functional abnormalities of the salience network are associated with schizophrenia, the acute effects of nicotine on its function and network dynamics during the resting state in patients are poorly understood. In this study, the effects of a 7 mg nicotine patch (vs. placebo) on salience network connectivity were examined in 17 patients with schizophrenia and 19 healthy subjects. We hypothesized abnormal connectivity between the salience network and other major networks (e.g. executive network) in patients under placebo administration and amelioration of this difference after nicotine. We also examined effects of nicotine on betweenness centrality (a measure of the influence of a region on information transfer throughout the brain) and local efficiency (a measure of local information transfer) of the network. A hybrid independent component analysis (ICA) / seed-based connectivity approach was implemented in which the salience network was extracted by ICA and cortical network peaks (anterior cingulate cortex (ACC), left and right insula) were used as seeds for whole-brain seed-to-voxel connectivity analysis. Significant drug X diagnosis interactions were observed between the ACC seed and superior parietal lobule and ventrolateral prefrontal cortex. A significant interaction effect was also observed between the left insula seed and middle cingulate cortex. During placebo conditions, abnormal connectivity predicted negative symptom severity and lower global functioning in patients. A significant drug X diagnosis interaction was also observed for betweenness centrality of the ACC. These results suggest that nicotine may target abnormalities in functional connectivity between salience and executive network areas in schizophrenia as well as affect the ability of the salience network to act as an integrator of global signaling in the disorder.

show abstract

“…The most consistent findings in patients with psychotic disorders include altered network connectivity 1-5 , network efficiency 1, 5-11 and network clustering 1, 5, 6, 9, 10 , which disrupt information integration and segregation of brain systems, leading to abnormal topological structures of the brain. Moreover, altered network properties have been found to be related to genetic risk for psychotic disorders 7, 9 , associated with severity of clinical symptoms 5, 8 and cognition 1, 7, 11 , and predictive of antipsychotic response 12, 13 . These lines of evidence suggest that changes in network integration and segregation may underlie the development of psychosis.…”

Section: Introductionmentioning

confidence: 99%

Progressive reconfiguration of resting-state brain networks as psychosis develops: Preliminary results from the North American Prodrome Longitudinal Study (NAPLS) consortium

Cao

Chung

McEwen

et al. 2017

Preprint

View full text Add to dashboard Cite

Mounting evidence has shown disrupted brain network architecture across the psychosis spectrum. However, whether these changes relate to the development of psychosis is unclear. Here, we used graph theoretical analysis to investigate longitudinal changes in resting-state brain networks in samples of 72 subjects at clinical high risk (including 8 cases who converted to full psychosis) and 48 healthy controls drawn from the North American Prodrome Longitudinal Study (NAPLS) consortium. We observed progressive reduction in global efficiency (P = 0.006) and increase in network diversity (P = 0.001) in converters compared with non-converters and controls. More refined analysis separating nodes into nine key brain networks demonstrated that these alterations were primarily driven by progressively diminished local efficiency in the default-mode network (P = 0.004) and progressively enhanced node diversity across all networks (P < 0.05). The change rates of network efficiency and network diversity were significantly correlated (P = 0.003), suggesting these changes may reflect shared underlying neural mechanisms. In addition, change rates of global efficiency and node diversity were significantly correlated with change rate of cortical thinning in the prefrontal cortex in converters (P < 0.03) and could be predicted by visuospatial memory scores at baseline (P < 0.04). These results provide preliminary evidence for longitudinal reconfiguration of resting-state brain networks during psychosis development and suggest that decreased network efficiency, reflecting an increase in path length between nodes, and increased network diversity, reflecting a decrease in the consistency of functional network organization, are implicated in the progression to full psychosis.

show abstract

Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents

Cited by 26 publications

References 64 publications

Brain network analysis reveals affected connectome structure in bipolar I disorder

Brain network analysis reveals affected connectome structure in bipolar I disorder

Nicotinic modulation of salience network connectivity and centrality in schizophrenia

Progressive reconfiguration of resting-state brain networks as psychosis develops: Preliminary results from the North American Prodrome Longitudinal Study (NAPLS) consortium

Contact Info

Product

Resources

About