DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia

Waltzman, Dana; Knowlton, Barbara J.; Cohen, Jessica R.; Bookheimer, Susan Y.; Bilder, Robert M.; Asarnow, Robert F.

doi:10.1016/j.pscychresns.2016.10.010

Cited by 3 publications

(1 citation statement)

References 72 publications

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“…Non-psychotic first degree relatives of patients with COS also showed impairments in attention/executive function 16 and smooth pursuit eye tracking 17 . Non-psychotic siblings of COS probands showed deficits on a procedural skill learning task supported by a cortical-striatal network 18 , widespread reductions in white matter microstructural integrity 19 , and reduced gray matter volume in a number of cortical and subcortical regions, but increased grey matter volume in the lingual gyrus and cerebellum 20 . A longitudinal study also found that prior to adolescence, the non-psychotic siblings of COS probands showed reduced cortical gray matter in superior temporal and prefrontal areas 21 ; however, these reductions normalized during adolescence.…”

Section: Familial Aggregation Of Neurobiological Abnormalitiesmentioning

confidence: 99%

Genetics of Childhood-onset Schizophrenia 2019 Update

Forsyth

Asarnow

2020

Child and Adolescent Psychiatric Clinics of North America

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they relate to the genetic architecture of schizophrenia. The authors subsequently provide an overview of major genetic findings for AOS, including reviewing studies of common, rare, and copy number variants in AOS. Finally, the authors will review genetic studies of COS, more specifically. Of note, many modern, large-scale genome-wide association studies of schizophrenia involve minimal patient characterization aside from establishing schizophrenia case status. As such, age of onset is often not reported. Since the vast majority of schizophrenia patients have their first psychotic episode in adulthood, the authors will refer to studies of broadly ascertained schizophrenia patients as AOS studies. In addition, in the discussion of familial aggregation studies, the authors focus on studies that examined risk in parents of schizophrenia probands rather than risk in siblings, because the siblings of COS probands typically have not entered the classical age of risk for schizophrenia. Familial aggregation of schizophreniaInitial genetic studies of AOS and COS examined family members of patients with AOS or COS to test the hypotheses that schizophrenia and/or schizophrenia spectrum disorders show familial aggregation. Every modern study that used relatively narrow, operationalized criteria for schizophrenia found that schizophrenia strongly aggregated in families of AOS patients relative to families of community controls. Modern family studies found a three-fold increase in the relative risk (RR) for schizophrenia among parents of AOS probands compared to the parents of controls 4 . Similarly, the morbid schizophrenia risk for parents and siblings of AOS probands was 6% and 9%, respectively, compared to 1% in the general population 5 . Adoption and twin studies further suggested that the increased risk of schizophrenia among family members of AOS probands was largely due to shared genetic factors, rather than shared environmental factors 4 .

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