A double-blind, multicenter immunotherapy trial in children, using a purified and standardized Cladosporium herbarum preparation. I. Clinical results

Immunotherapy for Allergic Disease

“…24 Some studies evaluating Alternaria immunotherapy have demonstrated an improvement in asthma symptoms and a decrease in medication use. One of the Cladosporium trials was conducted in children and demonstrated a decrease in allergen sensitivity on inhalation challenge, but did not provide good evidence of a decrease in symptoms or medication use.…”

“…a mixture of extracts of various allergens) immunotherapy. 24 The duration of treatment is generally 3 to 5 years, and symptomatic improvement continues for years after discontinuation. 11,20,21 These randomized, controlled trials have been the subject of a meta-analysis which demonstrated significant symptom relief and reduction of medication requirements.…”

Allergic and Immunologic Eye Disease

“…KD is usually benign and self-limited, although 2% of Japanese KD cases (nearly all male) experience sudden cardiac death 22 due to an acute thrombosis seasonal exacerbations. KD is an acute exanthematous illness that almost exclusively affects children: 50% of cases occurring in males less than 2 years of age, with an increased prevalence in individuals of Japanese ancestry.…”

Immunotherapy for Allergic Disease

“…23 Some studies evaluating Alternaria immunotherapy have demonstrated an improvement in asthma symptoms and a decrease in medication use. One of the Cladosporium trials was conducted in children and demonstrated a decrease in allergen sensitivity on inhalation challenge, but did not provide good evidence of a decrease in symptoms or medication use.…”

“…Many well-designed studies have examined the efficacy of immunotherapy for pollen-allergic patients with seasonal AR. 23 The duration of treatment is generally 3 to 5 years, and symptomatic improvement continues for years after discontinuation. 21 Immunotherapy has also been shown to be effective for mite-induced perennial AR 22 and may also be effective in mold-induced rhinitis.…”