A double blind crossover comparison of Diazepam (Valium, Ro 5?2807) with chlordiazepoxide (Librium) in the treatment of neurotic anxiety

Kerry, R. J.; Jenner, F. A.

doi:10.1007/bf00411370

Cited by 32 publications

(8 citation statements)

References 4 publications

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“…The trial was arranged on the same lines as our earlier studies (Kerry and Jenner, 1962;Jenrer and Kerry, 1967). The patient's condition was assessed at the first visit and changes in his condition were rated during subsequent visits.…”

Section: Methodsmentioning

confidence: 99%

Medazepam Compared with Amylobarbitone in Treatment of Anxiety

Kerry¹,

McDERMOTT²

1971

BMJ

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Section: Methodsmentioning

confidence: 99%

Medazepam Compared with Amylobarbitone in Treatment of Anxiety

Kerry¹,

McDERMOTT²

1971

BMJ

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“…In a similar trial on 32 patients, Kerry et al (1972) found that 10 mg bromazepam t.d.s. was significantly superior to chlordiazepoxide in the same dose.…”

Section: Discussionmentioning

confidence: 94%

A Comparison between Bromazepam (Ro 5-3350, Lexotan®) and Diazepam (Valium®) in Anxiety Neurosis

Sonne¹,

Holm²

1975

Int Pharmacopsychiatry

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The new benzodiazepine bromazepam (Ro 5-3350, Lexotan®) was compared with diazepam in a double-blind, crossover trial on 30 patients with prolonged anxiety symptoms. Each drug was given for 3 weeks in a dose of 5 mg t.d.s. Bromazepam proved to be statistically significantly superior to diazepam when evaluated through patients’ preferences. Fourteen patients preferred bromazepam to diazepam and four the opposite. Three cases were tied. Nine patients had to be withdrawn from the evaluation, which may create bias. A plea is made for further controlled clinical trials on bromazepam, in particular in obsessive and phobic neurosis.

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“…Chlordiazepoxide was less effective than the new benzodiazepines in 61 % of the studies, equivalent in 31%, and more effective in 8%. [8][9][10][11][12][13][14][15][16][17][18][19][20] The variance in results emphasizes the difficulties in interpreting large numbers of comparative clinical trials. The differences between drugs may be real or illusory, and this very often depends on the size and nature of the study population and the relative dosages of each drug.…”

Section: Clinical Differencesmentioning

confidence: 99%

Is Chlordiazepoxide the Rational Choice Among Benzodiazepines?

1982

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Diazepam is frequently the subject of review by various agencies and institutions charged with determining whether or not to substitute another, more economical drug--in most instances, chlordiazepoxide. A review of the comparative literature has shown that, on clinical and pharmacokinetic grounds, chlordiazepoxide is not the drug of choice for all clinical indications recommended for the benzodiazepines as a class, particularly for use as an antianxiety agent. There is evidence that the antianxiety effect of chlordiazepoxide is related to the appearance of its two active metabolites, which may explain the observed delay in its onset of action. When chlordiazepoxide's reduced clearance in the elderly and in patients with liver disease is considered along with its limited range of indications, substitution of diazepam with chlordiazepoxide is clearly not reasonable. Diazepam and lorazepam are preferred choices in acute anxiety because they are themselves active anxiolytics. Oxazepam is recommended in alcoholic cirrhotics because its plasma clearance does not seem to be significantly affected by liver disease. Diazepam is recommended for chronic anxiety because of the rapid onset of action of diazepam itself and the smooth transition to the nondrug state via its longer-acting active metabolite.

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A double blind crossover comparison of Diazepam (Valium, Ro 5?2807) with chlordiazepoxide (Librium) in the treatment of neurotic anxiety

Cited by 32 publications

References 4 publications

Medazepam Compared with Amylobarbitone in Treatment of Anxiety

Medazepam Compared with Amylobarbitone in Treatment of Anxiety

A Comparison between Bromazepam (Ro 5-3350, Lexotan®) and Diazepam (Valium®) in Anxiety Neurosis

Is Chlordiazepoxide the Rational Choice Among Benzodiazepines?

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