Medazepam Compared with Amylobarbitone in Treatment of Anxiety

Kerry, R. J.; McDERMOTT, C. M.

doi:10.1136/bmj.1.5741.151

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…One result of the present study, that the duration of action of a 10 mg dose of diazepam was 5 h, agrees with Linnoila & Hakkinen's (1974) and Korttila & Linnoila's (1975a, 1975b (Kerry & McDermott, 1971). Contrary to other benzodiazepines (Korttila & Linnoila, 1974) there was no impairment of coordinative skills after medazepam, and there was only a slight increase in the inaccuracy of reaction mistakes.…”

Section: Drug Dosessupporting

confidence: 91%

“…Most studies (Haider, 1971; DeBuck, Boon & Pelc, 1972;Hoffkes, 1972;Borenstein, Scoret & Cujor, 1973;Nanivadekar, Wig, Khorana, Master & Kulkarni, 1973;Sing & Saxena, 1974) suggest that diazepam (10 mg) is equipotent to lorazepam (2 mg or 2.5 mg) when the two are used as hypnotic drugs and as a treatment for anxiety neuroses. The dose of medazepam used in this study was based on the study of Kerry & McDermott (1971) on treatment of anxiety with medazepam.…”

Section: Drug Dosesmentioning

confidence: 99%

“…The 15 mg dose of medazepam used did not cause more fatigue or dizziness than the placebo, a finding which agrees with the small incidence of drowsiness and ataxia associated with treating anxiety with a 10 mg t.i.d. dosage of medazepam (Kerry & McDermott, 1971). Contrary to other benzodiazepines (Korttila & Linnoila, 1974) there was no impairment of coordinative skills after medazepam, and there was only a slight increase in the inaccuracy of reaction mistakes.…”

Section: Effects Of Medazepammentioning

confidence: 99%

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Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam.

Seppala¹,

Korttila²,

Häkkinen³

et al. 1976

Brit J Clinical Pharma

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1 Psychomotor skills and visual functions related to driving were measured double-blind cross-over in ten healthy volunteers before, and 1, 3, 5 and 7 h after a single oral administration of diazepam (10 mg), medazepam (15 mg) or lorazepam (2.5 mg). The late effects of lorazepam were tested in seven other subjects 12 and 24 h after the administration. 2 Lorazepam impaired almost all the measured skills more (P < 0.05 to 0.001) than diazepam, medazepam or the placebo. The lorazepam impairment of reactive skills and flicker fusion discrimination remained statistically significant (P < 0.05) for as long as 12 h. Medazepam impaired only reactive skills and flicker fusion, the latter remaining impaired (P < 0.05) for as long as 5 h after the administration. The magnitude and duration of the effects of diazepam were intermediate between those of lorazepam and medazepam. Diazepam impaired perceptual speed and reactive and co-ordinative skills as well as flicker fusion discrimination and visual parameters related to driving. Slight impairments in performance were measurable for up to 5 h after administration but at 7 h the results resembled those measured after the placebo. 3 The lack of alterations in adaptation to darkness, sensitivity to brightness or visual discrimination ability in bright counterlight at a time when flicker fusion discrimination was severely depressed suggests that an impaired ability to discriminate flickering light is of no or little clinical significance to driving ability. 4 It is concluded that patients receiving a 2.5 mg dose of lorazepam should not drive or operate machinery for 24 h after the administration. After diazepam (10 mg) or medazepam (15 mg) patients should refrain from driving or participating in skilled performances for only 5 to 7 hours.

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Section: Drug Dosessupporting

confidence: 91%

Section: Drug Dosesmentioning

confidence: 99%

Section: Effects Of Medazepammentioning

confidence: 99%

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Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam.

Seppala¹,

Korttila²,

Häkkinen³

et al. 1976

Brit J Clinical Pharma

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“…There have been many trials comparing new benzodiazepines with placebo and with barbiturates. In general, medazepam was effective in controlling anxiety in these trials (Daneman, 1969;Pasini, 1970;Perez Lopez, 1970;Kerry and McDermott, 1971). Fewer trials have compared the benzodiazepines among themselves.…”

mentioning

confidence: 99%

Clinical comparison of anxiolytic drug therapy

Lader¹,

Bond²,

James³

1974

Psychol. Med.

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SYSNOPSISTwenty outpatients suffering from chronic anxiety states completed a trial of anxiolytic drug therapy. They each received five treatments: amylobarbitone sodium, chlordiazepoxide, diazepam, medazepam, and a placebo in flexible dosage in a fully balanced design, using doubleblind procedures. They were assessed on the Hamilton rating scale for anxiety after a period of two to four weeks on each of the treatments and they completed self-ratings every three days. The selfratings were composed of at least three prime symptoms chosen by the patient himself and phrased in his own words as well as ‘loss of appetite’ and ‘insomnia’. Neither placebo nor amylobarbitone produced any substantial improvement from pre-drug levels of anxiety but all three benzodiazepines produced significant and very similar decreases in both Hamilton ratings and self-ratings. These two measures also correlated highly. The majority of the patients continued with medazepam at the end of the formal trial.

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The effect of medazepam and alcohol on cognitive and motor skills used in car driving

Landauer

Pocock

Prott

1974

Psychopharmacologia

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Medazepam Compared with Amylobarbitone in Treatment of Anxiety

Abstract: SummaryA double-blind crossover comparison of medazepam 10 mg three times a day against amylobarbitone 60 mg three times a day in outpatients with neurotic anxiety showed that medazepam was superior in relieving symptoms. At this dose of medazepam drowsiness or ataxia was rarely a problem.

Cited by 6 publications

References 4 publications

Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam.

Residual effects and skills related to driving after a single oral administration of diazepam, medazepam or lorazepam.

Clinical comparison of anxiolytic drug therapy

The effect of medazepam and alcohol on cognitive and motor skills used in car driving

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