A Comparison between Bromazepam (Ro 5-3350, Lexotan®)
and Diazepam (Valium®) in Anxiety Neurosis

Sonne, Lass Mahler; Holm, Per Sonne

doi:10.1159/000468179

Cited by 11 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Like all benzodiazepines, bromazepam proved to possess muscle relaxing activity, antineurotic and sedative effects [3][4][5]. The most characteristic effect of bromaze- pam is its anxiolytic power [6], which in clinical trials has been shown to be at least equal to [7,8] or superior than [9][10][11] that of diazepam and of lorazepam [12]. Bromazepam has also been shown to be effective as oral premedication in gynecological surgery [13,14] and to possess a good gastroprotective potential against stress-induced gastric ulceration, mediated by the inhibition of gastric secretion [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

et al. 2019

View full text Add to dashboard Cite

Aim: To assess the effects of chronic evening oral administration of bromazepam alone or in combination with propranolol on ambulatory blood pressure (BP) and heart rate (HR) in mild hypertensive subjects. Methods: Thirty-seven mild hypertensive patients after a 2-week placebo period were randomized to bromazepam 3 mg, propranolol 40 mg, bromazepam 3 mg plus propranolol 40 mg or placebo for 2 weeks according to a double-blind, double dummy, cross-over design. After each treatment period, 24-h BP and HR ambulatory monitoring was performed by using a non-invasive device. Results: Ambulatory monitoring showed that during night-time SBP and DBP values were unaffected by bromazepam as compared to placebo, whereas SBP was significantly reduced by propranolol both when taken alone and in combination with bromazepam. HR nocturnal values were significantly reduced by propranolol, whereas they were significantly increased by bromazepan both when taken alone (+11.5%, p < 0.05 vs. placebo) and in combination with propranolol (+12.8%, p < 0.05 vs. propranolol). No significant difference in day-time values of SBP, DBP and HR was observed among the 4 treatment groups. Conclusions: In mild hypertensive patients, evening consumption of bromazepam for a 2-week period did not affect BP, while it increased nocturnal HR. Such an increase was observed both when bromazepam was taken alone and in combination with propranolol, which suggests that it depends on a bromazepam mediated decrease in vagal tone. Whatever the mechanism, the HR nocturnal increase might be of clinical relevance, due to the role of high HR as cardiovascular risk factor, particularly in already at risk hypertensive subjects.

show abstract

Section: Introductionmentioning

confidence: 99%

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

et al. 2019

View full text Add to dashboard Cite

show abstract

Psychopharmacological Agents

Martin

Godel

Hunkeler

et al. 2000

Kirk-Othmer Encyclopedia of Chemical Technology

View full text Add to dashboard Cite

Martin, James R.; Godel, T.; Hunkeler, W.; Jenck, F.; Moreau, J‐L.; Sleight, A. J.; and Widmer, U. (F. Hoffmann‐La Roche Ltd.). A number of important advances have occurred in the understanding and the treatment of disorders of the central nervous system including mood disorders, schizophrenia, anxiety disorders, insomnia, substance use disorders, and dementias. The plethora of novel drugs act by means of diverse neurobiological mechanisms and represent a great diversity of chemical structures. Along with improvements in the therapeutic index of anxiolytics, sedative–hypnotics, antidepressants, and antipsychotics, some progress has also been made in the search for drugs effective in the treatment of substance use disorders, as well as Alzheimer's disease and other dementias. Nonetheless, such improvements in symptomatic therapy have not been accompanied by the discovery of effective etiological and pathophysiological interventions. It is from here that the successful psychopharmacological agents of the future must come.

show abstract

Effects of Antianxiety Drug and Personality on Stress‐Inducing Psychomotor Performance Test

Nakano

Ogawa

Kawazu

et al. 1978

The Journal of Clinical Pharma

View full text Add to dashboard Cite

The present study was carried out to clarify the effects of an antianxiety drug and of personality characteristics on a psychomotor performance test. Forty-eight healthy women college students were chosen from 64 volunteers as having either high or low levels of trait anxiety, neuroticism, or extroversion. Subjects with high trait anxiety and/or neuroticism tended to show a decrease in both speed and accuracy of the mirror drawing test (MDT) in the initial nondrug trials. Bromazepam, 5 mg, a benzodiazepine derivative, decreased this decrement in highly anxious subjects but worsened the speed in less anxious subjects. The personality traits of subjects, as well as the degree to which a performance test will induce stress, must be considered when evaluating the effects of antianxiety drugs on the performance of normal volunteers. The clinical anxiety-reducing efficacy of drugs may be predicted by using the MDT in subjects with high levels of anxiety and/or neuroticism.

show abstract

A Comparison between Bromazepam (Ro 5-3350, Lexotan®) and Diazepam (Valium®) in Anxiety Neurosis

Cited by 11 publications

References 2 publications

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

Effect of Evening Bromazepam Administration on Blood Pressure and Heart Rate in Mild Hypertensive Patients

Psychopharmacological Agents

Effects of Antianxiety Drug and Personality on Stress‐Inducing Psychomotor Performance Test

Contact Info

Product

Resources

About