A dosimetric comparison of 3D-CRT, IMRT, and static tomotherapy with an SIB for large and small breast volumes

Michalski, Andrea; Atyeo, John; Cox, Jennifer; Rinks, Marianne; Morgia, Marita; Lamoury, Gillian

doi:10.1016/j.meddos.2013.12.003

Cited by 46 publications

(38 citation statements)

References 23 publications

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“…Data published confirm that IMRT allows to decrease dose to critical organs, especially to the lungs [37,38]. IMRT has shown to be superior to 3-dimensional conformal radiotherapy in both planning target volume dose conformity and reduction of mean doses to the lung [39].…”

Section: Discussionmentioning

confidence: 93%

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Intensity modulated radiation therapy with simultaneous integrated boost in early breast cancer irradiation. Report of feasibility and preliminary toxicity

Fiorentino

Mazzola

Ricchetti

et al. 2015

Cancer/Radiothérapie

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Section: Discussionmentioning

confidence: 93%

“…Résultats. -Le suivi a été en médiane de 28 mois (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40). La toxicité cutanée aiguë a été de grade 0 chez huit patientes (7 %), 1 chez 80 (72 %), 2 chez 24 (21 %) et 3 chez aucune.…”

Section: Mots Clésunclassified

Intensity modulated radiation therapy with simultaneous integrated boost in early breast cancer irradiation. Report of feasibility and preliminary toxicity

Fiorentino

Mazzola

Ricchetti

et al. 2015

Cancer/Radiothérapie

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“…During the last years, however, simultaneous integrated boost radiation therapy superseded sequential boost therapy as the standard fractionation scheme [12, 13]. In this case, IMRT and VMAT have shown advantages in target coverage and sparing of the organs at risk (OAR) as compared to 3D-CRT techniques [10, 14], thus becoming more important also for right sided breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous integrated boost (SIB) radiation therapy of right sided breast cancer with and without flattening filter - A treatment planning study

et al. 2016

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BackgroundThe aim of the study was to compare the two irradiation modes with (FF) and without flattening filter (FFF) for three different treatment techniques for simultaneous integrated boost radiation therapy of patients with right sided breast cancer.MethodsAn Elekta Synergy linac with Agility collimating device is used to simulate the treatment of 10 patients. Six plans were generated in Monaco 5.0 for each patient treating the whole breast and a simultaneous integrated boost (SIB) volume: intensity modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT) and a tangential arc VMAT (tVMAT), each with and without flattening filter. Plan quality was assessed considering target coverage, sparing of the contralateral breast, the lungs, the heart and the normal tissue. All plans were verified by a 2D-ionisation-chamber-array and delivery times were measured and compared. The Wilcoxon test was used for statistical analysis with a significance level of 0.05.ResultsSignificantly best target coverage and homogeneity was achieved using VMAT FFF with V95% = (98.7 ± 0.8) % and HI = (8.2 ± 0.9) % for the SIB and V95% = (98.3 ± 0.7) % for the PTV, whereas tVMAT showed significantly lowest doses to the contralateral organs at risk with a Dmean of (0.7 ± 0.1) Gy for the contralateral lung, (1.0 ± 0.2) Gy for the contralateral breast and (1.4 ± 0.2) Gy for the heart. All plans passed the gamma evaluation with a mean passing rate of (99.2 ± 0.8) %. Delivery times were significantly reduced for VMAT and tVMAT but increased for IMRT, when FFF was used. Lowest delivery times were observed for tVMAT FFF with (1:20 ± 0:07) min.ConclusionBalancing target coverage, OAR sparing and delivery time, VMAT FFF and tVMAT FFF are considered the preferable of the investigated treatment options in simultaneous integrated boost irradiation of right sided breast cancer for the combination of an Elekta Synergy linac with Agility and the treatment planning system Monaco 5.0.

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“…First, intensity modulated radiotherapy (IMRT) techniques using volumetric arc therapy (V-MAT) or static tomotherapy can reduce the radiation dose to other tissues [6, 7]. Second, respiration control including the deep inhalation breath holding (DIBH) technique can reduce the irradiated heart volume [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the anatomical parameters for normal tissue sparing in the prone position radiotherapy with small sized left breasts

Kim

2016

Oncotarget

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Prone position radiotherapy for a small (< 750 cm3) breast is controversial because of the variable benefits for the irradiated heart volume. The objective anatomical parameters related with chest wall shape that can determine the heart dose sparing patients in the prone position.Twenty-one patients underwent CT-simulation in supine and prone position. Dose volume parameters were compared and the objective indexes such as the Haller index, anthropometric index, mid-sternum thickness, and central lung distance (CLD) were evaluated the relationship between the shape of the chest wall and irradiated normal tissue volume in prone position.The median breast volume was 440.10 cm3 (range, 151.5–727.41 cm3). There was no difference of breast target volume between supine and prone position (p = 0.178). The Haller index under 2.5 (p = 0.046), an anthropometric index over 0.05 (p = 0.007), and the CLD over 2 (p = 0.023) conferred a greater heart sparing effect in the prone position.In conclusions, the objective anatomical parameters related chest wall shape predict the decrease in irradiated heart volume in the prone position. Therefore, it is possible to screen for patients with a reduced heart volume irradiation among those with small breasts before applying prone position radiotherapy.

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A dosimetric comparison of 3D-CRT, IMRT, and static tomotherapy with an SIB for large and small breast volumes

Cited by 46 publications

References 23 publications

Intensity modulated radiation therapy with simultaneous integrated boost in early breast cancer irradiation. Report of feasibility and preliminary toxicity

Intensity modulated radiation therapy with simultaneous integrated boost in early breast cancer irradiation. Report of feasibility and preliminary toxicity

Simultaneous integrated boost (SIB) radiation therapy of right sided breast cancer with and without flattening filter - A treatment planning study

Evaluation of the anatomical parameters for normal tissue sparing in the prone position radiotherapy with small sized left breasts

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