1967
DOI: 10.1093/brain/90.3.545
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A Disorder of Rapid Eye Movements in Huntington's Chorea

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Cited by 276 publications
(49 citation statements)
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“…79,80 Research findings Impairment of both vertical and horizontal saccades was originally reported in patients suffering from manifest HD. 81 Contrary to earlier eye movement findings on premanifest HD individuals that reported intact performance, 82,83 a number of recent studies have reported deficits even in premanifest subjects. Initiation deficits of voluntary guided saccades, saccadic slowing, and delayed reflexive saccades were present.…”
Section: Clinical Ocular Motor Findingsmentioning
confidence: 78%
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“…79,80 Research findings Impairment of both vertical and horizontal saccades was originally reported in patients suffering from manifest HD. 81 Contrary to earlier eye movement findings on premanifest HD individuals that reported intact performance, 82,83 a number of recent studies have reported deficits even in premanifest subjects. Initiation deficits of voluntary guided saccades, saccadic slowing, and delayed reflexive saccades were present.…”
Section: Clinical Ocular Motor Findingsmentioning
confidence: 78%
“…Furthermore, the saccadometry research tool has proved valuable in separating premanifest, manifest, and controls who showed an increased incidence of early saccades with unusually short latencies. [84][85][86][87][88][89] Manifest patients early in the course of their disease, exhibit reduced saccadic velocity, 78,81,90 impaired initiation of saccades, an increase in the frequency of square-wave jerks, and an increase in saccadic latencies, that is greater for voluntary than reflexive saccades. They have excessive distractibility during attempted fixation, even when specifically instructed to maintain fixation on a centrally located target.…”
Section: Clinical Ocular Motor Findingsmentioning
confidence: 99%
“…In a clinical context, Yee et al (1985, p. 938) noted that due to the "maximal recruitment of motoneurons and extraocular muscle fibers […] during large saccades […] it would be expected that most disorders that impair the recruitment of motoneurons and muscle fibers or that otherwise interfere with the contraction of muscle fibers will decrease the peak velocity." Indeed, several pathologies are associated with alterations in saccadic peak velocity (Anderson & MacAskill, 2013), including progressive supranuclear palsy (Newman, Gay, Stroud, & Brooks 1970), Huntington's disease (Starr, 1967), and spinocerebellar degeneration (Zee, Optican, Cook, Robinson, & Engel, 1976). Therefore, it is crucial that amplitude and peak velocity of saccades can be accurately measured and restored from the recorded data.…”
Section: Introductionmentioning
confidence: 99%
“…This was initially considered an oculomotor apraxia 25,26,27,28,29 . However, Becker et al 26 evaluated horizontal head movements and eye-head coordination in 29 early stage HD patients and 24 age-matched controls.…”
mentioning
confidence: 99%
“…Another important point is the reduction of speed of these movements 25,26,28,28,30,32,36 . In a research study by Aron et al 39 that evaluated saccade velocity by video nystagmography in 21 patients with genetically confirmed HD and a control group of 15 subjects, the HD group exhibited decreased saccade velocity when compared with that of the control group.…”
mentioning
confidence: 99%