Ocular motor abnormalities in neurodegenerative disorders

Antoniades, C; Kennard, Christopher

doi:10.1038/eye.2014.276

Cited by 60 publications

(65 citation statements)

References 96 publications

(125 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Saccadic hypometria, which is considered one of the most consistent ocular motor abnormalities in PD (Antoniades & Kennard, ; Rottach, Riley, DiScenna, Zivotofsky, & Leigh, ) and was discovered in our patients with de novo PD, was not clearly pronounced in iRBD patients. This suggests that hypometria appears later in the disease course, in line with the progression of PD motor signs.…”

Section: Discussionmentioning

confidence: 51%

“…This is supported by previous studies which showed that poor antisaccade error rate performance correlates with neuropsychological test measures of prefrontal cortical function (Levy, Mendell, & Holzman, ; Postuma, Berg, et al, ; Postuma, Iranzo, et al, ). Higher antisaccadic error rates were also found in early‐stage drug‐naive PD patients (Antoniades & Kennard, ; Antoniades et al, ). Eye movement abnormalities have been presumed to occur even in the pre‐symptomatic phase of neurodegenerative disorders; however, there have been no studies characterizing eye movement metrics in iRBD performed so far (Antoniades & Kennard, ).…”

Section: Introductionmentioning

confidence: 95%

“…Higher antisaccadic error rates were also found in early‐stage drug‐naive PD patients (Antoniades & Kennard, ; Antoniades et al, ). Eye movement abnormalities have been presumed to occur even in the pre‐symptomatic phase of neurodegenerative disorders; however, there have been no studies characterizing eye movement metrics in iRBD performed so far (Antoniades & Kennard, ).…”

Section: Introductionmentioning

confidence: 95%

“…Eye movement analysis is a suitable tool to investigate brain function and to elucidate the pathophysiology of neurodegenerative diseases (Antoniades & Kennard, ). Studies of eye movement metrics in PD showed hypometric saccades, normal or mildly increased latency and an increased error rate in the antisaccadic paradigm (Antoniades, Demeyere, Kennard, Humphreys, & Hu, ; Leigh & Zee, ).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Eye movements in idiopathic rapid eye movement sleep behaviour disorder: High antisaccade error rate reflects prefrontal cortex dysfunction

Hanuška

Rusz

Bezdíček

et al. 2018

Journal of Sleep Research

View full text Add to dashboard Cite

Abnormalities of eye movements have been reported in patients with Parkinson's disease (PD). However, it is unclear if they occur in the prodromal stage of synucleinopathy represented by idiopathic rapid eye movement sleep behaviour disorder (iRBD). We thus aimed to study eye movements in subjects with iRBD and in de novo PD, to assess if their abnormalities may serve as a clinical biomarker of neurodegeneration. Fifty subjects with polysomnography-confirmed iRBD (46 male, age 40-79 years), 18 newly diagnosed, untreated PD patients (13 male, age 43-75 years) and 25 healthy controls (20 male, age 42-79 years) were prospectively enrolled. Horizontal and vertical ocular prosaccades and antisaccades were investigated with video-oculography. All patients completed the MDS-UPDRS and the Montreal Cognitive Assessment. In addition, a neuropsychological battery was performed on iRBD subjects. When compared with healthy controls, both de novo PD patients and iRBD subjects showed increased error rates in the horizontal antisaccade task (p < 0.01, p < 0.05 respectively). In the iRBD group, the error rates in horizontal and vertical antisaccades correlated with performances in the Prague Stroop Test and the Grooved Pegboard Test, as well as with motor scores of the MDS-UPDRS. De novo PD patients showed a lower gain (p < 0.01) compared with controls. In conclusion, the increased error rate in the antisaccade task of iRBD and PD patients reflects a dysfunction of the dorsolateral prefrontal cortex and is related to the impairment of executive functions and attention.

show abstract

Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Eye movements in idiopathic rapid eye movement sleep behaviour disorder: High antisaccade error rate reflects prefrontal cortex dysfunction

Hanuška

Rusz

Bezdíček

et al. 2018

Journal of Sleep Research

View full text Add to dashboard Cite

show abstract

“…As the neurodegeneration progresses, so does motor disability, manifesting in slowed and small movements (bradykinesia/hypokinesia) and muscle rigidity. Neurodegeneration also affects saccades (2)(3)(4)(5)(6)(7)(8), smooth pursuit eye movements (2)(3)(4)(5)(6)8,9) and visual perception (10). Reduced mobility creates difficulties for perceptual research on PD patients because impaired motor dexterity renders manual responses unreliable.…”

Section: Introductionmentioning

confidence: 99%

Optokinetic nystagmus reflects perceptual directions in the onset binocular rivalry in Parkinson’s disease

Fujiwara

Ding

Kaunitz

et al. 2016

Preprint

View full text Add to dashboard Cite

Optokinetic nystagmus (OKN), the reflexive eye movements evoked by a moving field, has recently gained interest among researchers as a useful tool to assess conscious perception.When conscious perception and stimulus are dissociated, such as in binocular rivalry -when dissimilar images are simultaneously presented to each eye and perception alternates between the two images over time -OKN correlates with perception rather than with the physical direction of the moving field. While this relationship is well established in healthy subjects it is yet unclear whether it also generalizes to clinical populations, for example, patients with Parkinson's disease. Parkinson's disease is a motor disorder, causing tremor, slow movements and rigidity. It may also be associated with oculomotor deficits, such as impaired saccades and smooth pursuit eye movements. Here, we employed short-duration, onset binocular rivalry (2 s trial of stimulus presentation followed by 1 s inter-trial interval) with moving grating stimuli to assess OKN in Parkinson's disease patients (N=39) and controls (N=29) of a similar age.Each trial was either non-rivalrous (same stimuli presented to both eyes) or rivalrous, as in binocular rivalry. We analyzed OKN to discriminate direction of stimulus and perception on a trial-by-trial basis. OKN reflected conscious perceptions in both groups. Treatment with anti-Parkinson drugs and deep brain stimulation improved motor ability of patients assessed by a standard scale of Parkinson's disease, but did not impact on OKN. Furthermore, OKN-based measures were robust and their latencies were shorter than manual button-based measures in all subjects, regardless of stimulus condition. Our findings suggest that OKN can be used as an indicator of conscious perception in binocular rivalry even in Parkinson's disease patients in whom impaired manual dexterity may render button-press reports less reliable.

show abstract

Pro‐Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE‐PD

et al. 2019

View full text Add to dashboard Cite

A BS TRACT: Background: Cumulative dementia incidence in Parkinson's disease (PD) is significant, with major personal and socioeconomic impacts on individuals with PD and their carers. Early identification of dementia risk is vital to ensuring optimal intervention. Saccadic deficits often distinguish neurodegenerative disorders and cognitive impairment, but their ability to predict cognitive decline in PD has yet to be determined. The aims of this study were to (1) evaluate baseline (6.4 AE 6.1 months since PD diagnosis) differences in pro-saccadic metrics between those with early PD and healthy age-matched adults; and (2) assess the ability of baseline pro-saccades to predict subsequent cognitive decline over 4.5 years. Methods: One hundred and forty-one PD and 90 agematched participants recruited at diagnosis underwent saccadometric assessment of pro-saccades at baseline and had cognition assessed at baseline, 18, 36, and 54 months. Pro-saccadic characteristics included latency, duration, amplitude, peak, and average velocity. Cognitive assessment included executive function, attention, fluctuating attention, and memory. Linear mixed-effects models examined pro-saccadic metrics as predictors of cognitive decline over 54 months. Results: Pro-saccades were significantly impaired at baseline in PD compared with controls. Pro-saccadic characteristics of latency, duration, peak, and average velocity predicted decline in global cognition, executive function, attention, and memory over 54 months in PD. In addition, only reduction in global cognition and attention were predicted by pro-saccadic metrics in age-matched adults, indicating that PD findings were not purely age related. Conclusions: Saccadic characteristics are impaired in early PD and are predictive of cognitive decline in several domains. Assessment of saccades may provide a useful non-invasive biomarker for long-term PD cognitive decline in early disease.

show abstract

Ocular motor abnormalities in neurodegenerative disorders

Cited by 60 publications

References 96 publications

Eye movements in idiopathic rapid eye movement sleep behaviour disorder: High antisaccade error rate reflects prefrontal cortex dysfunction

Eye movements in idiopathic rapid eye movement sleep behaviour disorder: High antisaccade error rate reflects prefrontal cortex dysfunction

Optokinetic nystagmus reflects perceptual directions in the onset binocular rivalry in Parkinson’s disease

Pro‐Saccades Predict Cognitive Decline in Parkinson's Disease: ICICLE‐PD

Contact Info

Product

Resources

About